Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Dian Ding"'
Autor:
Weize Wang, Ling Liang, Zonglin Dai, Peng Zuo, Shang Yu, Yishuo Lu, Dian Ding, Hongyi Chen, Hui Shan, Yan Jin, Youdong Mao, Yuxin Yin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The CUL3-RING E3 ubiquitin ligases (CRL3s) play an essential role in response to extracellular nutrition and stress stimuli. The ubiquitin ligase function of CRL3s is activated through dimerization. However, how and why such a dimeric assemb
Externí odkaz:
https://doaj.org/article/a3fe32b50b3848b2aed23ead80582850
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116605- (2024)
The recent Global Burden of Disease results have demonstrated that oral diseases are some of the most significant public health challenges facing the world. Owing to its specific localization advantage, superoxide dismutase 2 (SOD2 or MnSOD) has the
Externí odkaz:
https://doaj.org/article/425a054d2fa342c583d77230e318a576
Autor:
Weiqi Zhang, Dian Ding, Yishuo Lu, Hongyi Chen, Peijun Jiang, Peng Zuo, Guangxi Wang, Juan Luo, Yue Yin, Jianyuan Luo, Yuxin Yin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Anion exchanger 2 (AE2) is an electroneutral Na+-independent Cl-/HCO3 - exchanger belongs to the SLC4 transporter family. The widely expressed AE2 participates in a variety of physiological processes, including transepithelial acid-base secr
Externí odkaz:
https://doaj.org/article/626daefa3e674cdb9e931db7bbc90d2a
Autor:
Yishuo Lu, Peng Zuo, Hongyi Chen, Hui Shan, Weize Wang, Zonglin Dai, He Xu, Yayu Chen, Ling Liang, Dian Ding, Yan Jin, Yuxin Yin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract BTR1 (SLC4A11) is a NH3 stimulated H+ (OH-) transporter belonging to the SLC4 family. Dysfunction of BTR1 leads to diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy (FECD). However, t
Externí odkaz:
https://doaj.org/article/eb4d2c48aae949aba8322414a530f65d
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract KATP channels are metabolic sensors for intracellular ATP/ADP ratios, play essential roles in many physiological processes, and are implicated in a spectrum of pathological conditions. SUR2A-containing KATP channels differ from other subtype
Externí odkaz:
https://doaj.org/article/ba87dd3ea35e4a978b73d370515339f8
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
SUR2-containing KATP channels are drug targets for certain vasodilators. Here, the authors determine high-resolution cryo-EM structures of SUR2 in complex with two vasodilators, P1075 and levcromakalim, uncovering the mechanisms of these drugs.
Externí odkaz:
https://doaj.org/article/14b24293475b4e569f7f098ba1a7a2c6
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
KATP channels are energy sensors. Here, authors report the Cryo-EM structures of pancreatic KATP in both the closed state and the pre-open state. These structures illuminate the mechanism of KATP channel regulation by the intracellular nucleotides.
Externí odkaz:
https://doaj.org/article/b74e9dfbf03d4845bf182890861ed3a8
Autor:
Xi Lu, Shaojun Zhang, Jia Xing, Yunjie Wang, Wenhui Chen, Dian Ding, Ye Wu, Shuxiao Wang, Lei Duan, Jiming Hao
Publikováno v:
Engineering, Vol 6, Iss 12, Pp 1423-1431 (2020)
China’s past economic growth has substantially relied on fossil fuels, causing serious air pollution issues. Decoupling economic growth and pollution has become the focus in developing ecological civilization in China. We have analyzed the three-de
Externí odkaz:
https://doaj.org/article/1fc1bc64b4e64435bca5c30ae199e282
Autor:
Yuqiang Zhang, Bin Zhao, Yueqi Jiang, Jia Xing, Shovan K. Sahu, Haotian Zheng, Dian Ding, Suzhen Cao, Licong Han, Cong Yan, Xiaoli Duan, Jingnan Hu, Shuxiao Wang, Jiming Hao
Publikováno v:
Environment International, Vol 158, Iss , Pp 106918- (2022)
Background: Ambient and household air pollution are found to lead to premature deaths from all-cause or cause-specific death. The national lockdown measures in China during COVID-19 were found to lead to abrupt changes in ambient surface air quality,
Externí odkaz:
https://doaj.org/article/c1e322b1ff8a4d9ebbe6514bd081cc61
Publikováno v:
Remote Sensing, Vol 14, Iss 18, p 4683 (2022)
We identified controlling factors of the inter-annual variations of surface PM2.5–aerosol optical depth (AOD) relationship in China from 2006 to 2017 using a nested 3D chemical transport model—GEOS-Chem. We separated the contributions from anthro
Externí odkaz:
https://doaj.org/article/43775de5b6e446eebdb593ee13aa9242