JAG1-NOTCH4 mechanosensing drives atherosclerosis

Autor: Souilhol, C, Tardajos Ayllon, B, Li, X, Diagbouga, MR, Zhou, Z, Canham, L, Roddie, H, Pirri, D, Chambers, EV, Dunning, MJ, Ariaans, M, Li, J, Fang, Y, Jørgensen, HF, Simons, M, Krams, R, Waltenberger, J, Fragiadaki, M, Ridger, V, De Val, S, Francis, SE, Chico, TJA, Serbanovic-Canic, J, Evans, PC

Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and homeostasi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7b23f9ed0fb742ab6ea4e485343238
https://www.repository.cam.ac.uk/handle/1810/341580

Impact of disrupted cyclic stretch in intracranial aneurysms: Insights from endothelial cell transcriptomic dataset.

Autor: Diagbouga MR; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland., Lemeille S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland., Morel S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Division of Neurosurgery, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals and University of Geneva. Rue Gabrielle-Perret-Gentil 4, 1211 Geneva, Switzerland., Kwak BR; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland.; Geneva Center for Inflammation Research, Faculty of Medicine, University of Geneva. Rue Michel-Servet 1, 1211 Geneva, Switzerland.

Publikováno v: Data in brief [Data Brief] 2023 Dec 28; Vol. 52, pp. 110014. Date of Electronic Publication: 2023 Dec 28 (Print Publication: 2024).

JAG1-NOTCH4 mechanosensing drives atherosclerosis.

Autor: Souilhol C; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.; Biomolecular Sciences Research Centre, Sheffield Hallam University, Sheffield, UK., Tardajos Ayllon B; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Li X; School of Pharmacy, Southwest Medical University, LuZhou, Sichuan 646000, P.R. China., Diagbouga MR; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Zhou Z; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Canham L; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Roddie H; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Pirri D; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Chambers EV; Sheffield Bioinformatics Core, Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK., Dunning MJ; Sheffield Bioinformatics Core, Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK., Ariaans M; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Li J; Biological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL, USA., Fang Y; Biological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL, USA., Jørgensen HF; Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK., Simons M; Department of Internal Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA., Krams R; Department of Bioengineering, Queen Mary University of London, London, UK., Waltenberger J; Department of Cardiovascular Medicine, Medical Faculty, University of Münster, Münster, Germany.; Hirslanden Klinik im Park, Cardiovascular Medicine, Diagnostic and Therapeutic Heart Center AG, 8002 Zürich, Switzerland., Fragiadaki M; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Ridger V; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., De Val S; BHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.; Ludwig Institute for Cancer Research Ltd, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7DQ, UK., Francis SE; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Chico TJ; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Serbanovic-Canic J; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK., Evans PC; Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.

Publikováno v: Science advances [Sci Adv] 2022 Sep 02; Vol. 8 (35), pp. eabo7958. Date of Electronic Publication: 2022 Aug 31.

Effects of Low and High Aneurysmal Wall Shear Stress on Endothelial Cell Behavior: Differences and Similarities.

Autor: Morel S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.; Neurosurgery Division, Department of Clinical Neurosciences, Faculty of Medicine, Geneva University Hospitals, Geneva, Switzerland., Schilling S; Institute of Applied Simulation, Zurich University of Applied Sciences, Wädenswil, Switzerland.; Institute of Tourism and Mobility, Lucerne School of Business, Lucerne University of Applied Sciences and Arts, Lucerne, Switzerland., Diagbouga MR; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Delucchi M; Institute of Applied Simulation, Zurich University of Applied Sciences, Wädenswil, Switzerland., Bochaton-Piallat ML; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Lemeille S; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland., Hirsch S; Institute of Applied Simulation, Zurich University of Applied Sciences, Wädenswil, Switzerland., Kwak BR; Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Publikováno v: Frontiers in physiology [Front Physiol] 2021 Oct 14; Vol. 12, pp. 727338. Date of Electronic Publication: 2021 Oct 14 (Print Publication: 2021).

KLF4-Induced Connexin40 Expression Contributes to Arterial Endothelial Quiescence.

Autor: Denis JF; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Diagbouga MR; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Molica F; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Hautefort A; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Linnerz T; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Watanabe M; Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan., Lemeille S; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Bertrand JY; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland., Kwak BR; Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland.; Department of Medical Specializations - Cardiology, University of Geneva, Geneva, Switzerland.

Publikováno v: Frontiers in physiology [Front Physiol] 2019 Feb 12; Vol. 10, pp. 80. Date of Electronic Publication: 2019 Feb 12 (Print Publication: 2019).