Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Diabetes and Endocrinology/Type 1 Diabetes"'
Autor:
Ashleigh S. Boyd, Kathryn J. Wood
Publikováno v:
PLoS ONE
PLoS ONE; Vol 5
PLoS ONE, Vol 5, Iss 6, p e10965 (2010)
PLoS ONE; Vol 5
PLoS ONE, Vol 5, Iss 6, p e10965 (2010)
BACKGROUND: The fully differentiated progeny of ES cells (ESC) may eventually be used for cell replacement therapy (CRT). However, elements of the innate immune system may contribute to damage or destruction of these tissues when transplanted. METHOD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc44db1ddbbab7260a755f09f04885f
https://doi.org/10.1371/journal.pone.0010965
https://doi.org/10.1371/journal.pone.0010965
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 5, p e14796 (2011)
PLoS ONE, Vol 6, Iss 5, p e14796 (2011)
During the progression of the clinical onset of Type 1 Diabetes (T1D), high-risk individuals exhibit multiple islet autoantibodies and high-avidity T cells which progressively destroy beta cells causing overt T1D. In particular, novel autoantibodies,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::befc5ea25f8aa4c139dbc5c6514f7275
http://europepmc.org/articles/PMC3091860
http://europepmc.org/articles/PMC3091860
Autor:
Peter Arvan, Michael A. Weiss, Qing Xin Hua, Leena Haataja, Fabrizio Barbetti, Nalinda P. Wickramasinghe, Jordan J. Wright, Nelson F. Phillips, Ming Liu
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13333 (2010)
PLoS ONE
PLoS ONE
Recently, a syndrome of Mutant I NS-gene-induced Diabetes of Youth (MIDY, derived from one of 26 distinct mutations) has been identified as a cause of insulin-deficient diabetes, resulting from expression of a misfolded mutant proinsulin protein in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4cd223bd25ebec0f24ffe743eb537a
http://europepmc.org/articles/PMC2952628?pdf=render
http://europepmc.org/articles/PMC2952628?pdf=render
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12236 (2010)
PLoS ONE
PLoS ONE
Positive selection is known to occur when the environment that an organism inhabits is suddenly altered, as is the case across recent human history. Genome-wide association studies (GWASs) have successfully illuminated disease-associated variation. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78da42f4a8f1eecf307b4e96e04afa6
http://europepmc.org/articles/PMC2923198?pdf=render
http://europepmc.org/articles/PMC2923198?pdf=render
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11564 (2010)
PLoS ONE
PLoS ONE
Background The Thr allele at the non-synonymous single-nucleotide polymorphism (nsSNP) Thr946Ala in the IFIH1 gene confers risk for Type 1 diabetes (T1D). The SNP is embedded in a 236 kb linkage disequilibrium (LD) block that includes four genes: IFI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ede63b3bc38f5f57da702997c7afd5
http://europepmc.org/articles/PMC2903489?pdf=render
http://europepmc.org/articles/PMC2903489?pdf=render
Autor:
Adam R. Wende, Shannon P. O'Grady, Lesley A. Chesson, Christopher H. Remien, E. Dale Abel, James R. Ehleringer, Lindsey E. Enright, Thure E. Cerling, Luciano O. Valenzuela
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11699 (2010)
PLoS ONE
PLoS ONE
While isotopes are frequently used as tracers in investigations of disease physiology (i.e., 14C labeled glucose), few studies have examined the impact that disease, and disease-related alterations in metabolism, may have on stable isotope ratios at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d4e2476b5ff094cb1e1825803c8ed16
http://europepmc.org/articles/PMC2908146?pdf=render
http://europepmc.org/articles/PMC2908146?pdf=render
Autor:
Yonghong Shi, Sandra M. Malakauskas, Jun Wada, Huijun Duan, Yanling Zhang, Chunyang Du, Yunzhuo Ren, Qingxian Zhang, Yingmin Li, Maodong Liu, Ying Li
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 7, p e11709 (2010)
PLoS ONE, Vol 5, Iss 7, p e11709 (2010)
Diabetic nephropathy is a complex and poorly understood disease process, and our current treatment options are limited. It remains critical, then, to identify novel therapeutic targets. Recently, a developmental protein and one of the bone morphogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de63f6b8e2b78790c0892393ab94c16
http://europepmc.org/articles/PMC2908623
http://europepmc.org/articles/PMC2908623
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11146 (2010)
PLoS ONE
PLoS ONE
Aims/hypothesis We aimed to understand early alterations in kinin-mediated migration of circulating angio-supportive cells and dysfunction of kinin-sensitive cells in type-1 diabetic (T1D) patients before the onset of cardiovascular disease. Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceda7a897399b36a54d1ddf662c91e72
http://europepmc.org/articles/PMC2887352?pdf=render
http://europepmc.org/articles/PMC2887352?pdf=render
Autor:
Dan S. Luciani, Timothy J. Kieffer, James D. Johnson, Michael J. Riedel, Kevin Tsai, Ziliang Ao, Corinne A. Hoesli, James M. Piret, Tatyana B. Kalynyak, Marta Szabat, David E. Williams, Yu Hsuan Carol Yang, Raymond J. Andersen, Garth L. Warnock, Blair K. Gage, Jessica A. Hill
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
PLoS ONE, Vol 5, Iss 9, p e12958 (2010)
Diabetes is a devastating disease that is ultimately caused by the malfunction or loss of insulin-producing pancreatic beta-cells. Drugs capable of inducing the development of new beta-cells or improving the function or survival of existing beta-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ff5d2d1a60c10857e76deb5873ee1d
https://pubmed.ncbi.nlm.nih.gov/20886041
https://pubmed.ncbi.nlm.nih.gov/20886041
Autor:
Ulysses J. Balis, Gordon C. Weir, Jeffrey Kennedy, Lorella Marselli, Min-Ho Jung, Allison B. Goldfine, Susan Bonner-Weir, Hitoshi Katsuta, Dennis C. Sgroi
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 6, p e11211 (2010)
PLoS ONE, Vol 5, Iss 6, p e11211 (2010)
Background: There is great interest about the possible contribution of ER stress to the apoptosis of pancreatic beta cells in the diabetic state and with islet transplantation. Methods and Findings: Expression of genes involved in ER stress were exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b57ddec4ae5afad8d04d1a2cba798fca
https://pubmed.ncbi.nlm.nih.gov/20585452
https://pubmed.ncbi.nlm.nih.gov/20585452