Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link?

Autor: François R Jornayvaz, Mohamed Asrih

Publikováno v: Molecular and Cellular Endocrinology, Vol. 418, No Pt 1 (2015) pp. 55-65

Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d5670e5ed9a734f44c8865a58e1cac
https://doi.org/10.1016/j.mce.2015.02.018

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

Autor: Yunzhao Tang, Ola Hansson, Thomas Reinbothe, Taman Mahdi, Yuedan Zhou, Jonathan M. J. Derry, Valeriya Lyssenko, Jalal Taneera, Leif Groop, Claes B. Wollheim, Xingjun Jing, Albert Salehi, Lena Eliasson, Ulrika Krus, Jonathan L.S. Esguerra, Peter Almgren, Anders Rosengren, Enming Zhang, Erik Renström, Sonja Hänzelmann, Sarheed Jabar Muhammed, Anna M. Blom, Annika S. Axelsson

Publikováno v: Cell Metabolism, Vol. 16, No 5 (2012) pp. 625-33
Cell Metabolism; 16(5), pp 625-633 (2012)

SummaryA plethora of candidate genes have been identified for complex polygenic disorders, but the underlying disease mechanisms remain largely unknown. We explored the pathophysiology of type 2 diabetes (T2D) by analyzing global gene expression in h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126bd5ad8c16d23d81421a3a35eabee6
http://lup.lub.lu.se/record/3219063/file/3878932.pdf

Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training

Autor: Francis M. Finucane, Nicole Burns, Mensud Hatunic, M. Murphy, John J. Nolan, Andrea Mari, D. Gasparro, Amalia Gastaldelli, M. Gilman

Publikováno v: Diabetologia (Berl.) 50 (2007): 1500–1508.
info:cnr-pdr/source/autori:Burns N.; Finucane F.; Hatunic M.; Gilman M.; Murphy M.; Gasparro D.; Mari A.; Gastaldelli A.; Nolan J./titolo:Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training/doi:/rivista:Diabetologia (Berl.)/anno:2007/pagina_da:1500/pagina_a:1508/intervallo_pagine:1500–1508/volume:50

AIMS/HYPOTHESIS: Early-onset type 2 diabetes is associated with marked visceral obesity and extreme insulin resistance, but its pathogenesis and response to treatment are not completely understood. We studied physical fitness, whole-body and hepatic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf7b6a703c40aba9fcacf43508ac3b9
http://www.ncbi.nlm.nih.gov/pubmed/17393133