Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Diabetes Mellitus, Type 1/immunology"'
2
Stem-cell-based Therapies for Improving Islet Transplantation Outcomes in Type 1 Diabetes
Autor: João Paulo Monteiro Carvalho Mori da Cunha, Conny Gysemans, Chantal Mathieu, Pieter Gillard
Introduction: Beta-cell replacement by human islets or whole pancreas offers a life-saving therapeutic remedy for patients suffering from type 1 diabetes, providing considerable advantages with respect to diminishing total daily insulin dose and lowe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef61d54f799976b9b1b1e394cf524c4
https://doi.org/10.2174/1573399812666160629094031
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3
Identification of Donor Origin and Condition of Transplanted Islets in Situ in the Liver of a Type 1 Diabetic Recipient
Autor: Cornelis R. van der Torren, Ernst-Jan T van 't Wout, Jessica S Suwandi, Pieter Gillard, Frans H.J. Claas, Godelieve Swings, Zhidong Ling, DaHae Lee, Pieter In 'T Veld, Gaby Duinkerken, Bart O. Roep, Bart Keymeulen, Arend Mulder
Publikováno v: Cell Transplantation, Vol 26 (2017)
Cell Transplantation, 26(1), 1-9
Transplantation of islet allografts into type 1 diabetic recipients usually requires multiple pancreas donors to achieve insulin independence. This adds to the challenges of immunological monitoring of islet transplantation currently relying on surro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03120b927374e3d4310f24a9d03e09a5
https://doaj.org/article/4fc08ec296f34a08bf92a0beb0387133
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4
Enhanced Anti-Serpin Antibody Activity Inhibits Autoimmune Inflammation in Type 1 Diabetes
Autor: Richard A. Flavell, Enric Esplugues, Jan Czyzyk, Raman Baldzizhar, Kevan C. Herold, Paula Preston-Hurlburt, Frans Gorus, Christine Fedorchuk, Kim Bottomly, Octavian Henegariu
Publikováno v: The Journal of Immunology. 188:6319-6327
Intracellular (clade B) OVA-serpin protease inhibitors play an important role in tissue homeostasis by protecting cells from death in response to hypo-osmotic stress, heat shock, and other stimuli. It is not known whether these serpins influence immu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d1d694d912d176e747fb20418a7a7f
https://doi.org/10.4049/jimmunol.1200467
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5
Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis
Autor: Carla Borri Voltattorni, Itamar Kass, Nathan Cowieson, Malcolm Buckle, David Perahia, Mauricio G. S. Costa, Daniel Christ, David B. Langley, David E. Hoke, Eugenia Pennacchietti, Ian R. Mackay, Oded Kleifeld, Cyril F. Reboul, Hervé Leh, Benjamin T. Porebski, Ashley M. Buckle, Julia M. McCoey, Brendan Roome, Daniela De Biase, Alessandro Paiardini
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2014, 111 (25), pp.E2524-2529. ⟨10.1073/pnas.1403182111⟩
International audience; The human neuroendocrine enzyme glutamate decarboxylase (GAD) catalyses the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) using pyridoxal 5′-phosphate as a cofactor. GAD exists as two isoforms n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d16d55162420f70d6b6626fd7318824
https://hal-riip.archives-ouvertes.fr/pasteur-01146884
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6
The GM2-1 Ganglioside Islet Autoantigen in Insulin-Dependent Diabetes Mellitus Is Expressed in Secretory Granules and Is Notβ -Cell Specific*
Autor: Marguerite Neerman-Arbez, Luisa Lenti, Philippe A. Halban, Francesco Dotta, Domenico Cucinotta, S. Dionisi, U. Di Mario, M. Previti
Publikováno v: Endocrinology, Vol. 139, No 1 (1998) pp. 316-319
The pancreatic islet monosialo-ganglioside (GM2-1), an autoantigen in insulin-dependent diabetes mellitus (IDDM) recently shown to be the target of autoantibodies associated with diabetes development in relatives of IDDM patients, is islet specific w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9ab062bdaa7afed2f984616947145b
https://doi.org/10.1210/endo.139.1.5708
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7
Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands
Autor: Petrich de Marquesini, L. G., Moustakas, A. K., Thomas, I. J., Wen, L., Papadopoulos, G. K., Wong, F. S.
Insulin-reactive CD8 T cells are amongst the earliest islet-infiltrating CD8 T cells in NOD mice. Cloned insulin B15-23-reactive cells (designated G9C8), restricted by H-2K(d), are highly diabetogenic. We used altered peptide ligands (APL) substitute
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10561::194d031765e2e7895442d86e481ae293
http://olympias.lib.uoi.gr/jspui/handle/123456789/21477
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8
Relative diabetogenic properties of islet-specific Tc1 and Tc2 cells in immunocompetent hosts
Autor: Nadège Bercovici, Karine Goude, Christophe Combadière, Karine Bailly, Roland S. Liblau, Nathalie Pardigon, Csaba Vizler, Agnès Heurtier
Publikováno v: Journal of Immunology
Journal of Immunology, 2000, 165 (11), pp.6314-21. ⟨10.4049/jimmunol.165.11.6314⟩
Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2000, 165 (11), pp.6314-21. ⟨10.4049/jimmunol.165.11.6314⟩
ResearcherID
CD8+ T cells are important effectors, as well as regulators, of organ-specific autoimmunity. Compared with Tc1-type CD8+ cells, Tc2 cells have impaired anti-viral and anti-tumor effector functions, although no data are yet available on their pathogen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a593d4c7f1f80e4db6d889a97fad81ed
https://hal-pasteur.archives-ouvertes.fr/pasteur-01659367
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9
RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes
Autor: Hadi Khalil, Nieves Peltzer, Christian Widmann, Jiang-Yan Yang, Evrim Jaccard, Natasa Bulat, Gilles Dubuis
Publikováno v: PLOS ONE
PLoS One, vol. 6, no. 7, pp. e22609
PLoS ONE
PLoS ONE, Vol 6, Iss 7, p e22609 (2011)
The caspase-3-generated RasGAP N-terminal fragment (fragment N) inhibits apoptosis in a Ras-PI3K-Akt-dependent manner. Fragment N protects various cell types, including insulin-secreting cells, against different types of stresses. Whether fragment N
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b9f33fe6ea49832e6150dc446835681
http://journals.plos.org/plosone/article/asset?id=10.1371/journal.pone.0022609.PDF
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