Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery

Autor: D. Elleri, Malgorzata E. Wilinska, Sabine E. Hofer, Thomas R. Pieber, Fiona Campbell, Sabine Arnolds, Carine de Beaufort, Amy Criego, David B. Dunger, Thomas Kapellen, Elke Fröhlich-Reiterer, Roman Hovorka, Birgit Rami-Merhar, Martin Tauschmann, KidsAP Consortia, Lalantha Leelarathna, Hood Thabit, Carlo L. Acerini, Klemen Dovc, Viral N. Shah, Mark L. Evans, Charlotte K. Boughton, Richard M. Bergenstal, Janet M. Allen, Judy Sibayan, Lia Bally

Publikováno v: Diabetes Care
APCam11 Consortium, AP@home Consortium & KidsAP Consortia 2019, ' Young Children Have Higher Variability of Insulin Requirements : Observations During Hybrid Closed-Loop Insulin Delivery ', Diabetes Care, vol. 42, no. 7, pp. 1344-1347 . https://doi.org/10.2337/dc18-2625

OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a432b3d3cb4aa049461d91ac8f227e58
https://doi.org/10.2337/dc18-2625

Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy

Autor: Jan Hoong Ho, Ioannis N. Petropoulos, Shaishav Dhage, Andrew Atkinson, Uazman Alam, Maryam Ferdousi, Safwaan Adam, Georgios Ponirakis, Handrean Soran, Shazli Azmi, Alise Kalteniece, Maria Jeziorska, Andrew Marshall, Rayaz A. Malik

Publikováno v: SCIENTIFIC REPORTS
Scientific Reports
Dhage, S, Ferdousi, M, Adam, S, Ho, J H, Kalteniece, A, Azmi, S, Alam, U, Ponirakis, G, Petropoulos, I, Atkinson, A J, Marshall, A, Jeziorska, M, Soran, H & Malik, R A 2021, ' Corneal confocal microscopy identifies small fibre damage and progression of diabetic neuropathy ', Scientific Reports, vol. 11, no. 1, 1859 . https://doi.org/10.1038/s41598-021-81302-8
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Accurately quantifying the progression of diabetic peripheral neuropathy is key to identify individuals who will progress to foot ulceration and to power clinical intervention trials. We have undertaken detailed neuropathy phenotyping to assess the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8150cd3efbd65beabb01334985afafbb

Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries: A Cross-sectional Analysis of 64,666 Children and Adolescents With Type 1 Diabetes

Autor: Siv J Kummernes, Ann-Marie Svensson, Terence Stephenson, Dimitrios Charalampopoulos, Knut Dahl-Jørgensen, Niels H Birkebaek, Lena Hanberger, Torild Skrivarhaug, Anders Johansen, Julia M. Hermann, Nicole C. Foster, Sabine E. Hofer, Birgit Rami-Merhar, Justin T. Warner, Rakesh Amin, Ragnar Hanas, Reinhard W. Holl, Siri Fredheim, Karin Åkesson, Mark A. Clements, David M. Maahs, Jannet Svensson, Kellee M. Miller, A K Drivvoll

Publikováno v: Charalampopoulos, D, Hermann, J M, Svensson, J, Skrivarhaug, T, Maahs, D M, Akesson, K, Warner, J T, Holl, R W, Birkebæk, N H, Drivvoll, A K, Miller, K M, Svensson, A-M, Stephenson, T, Hofer, S E, Fredheim, S, Kummernes, S J, Foster, N, Hanberger, L, Amin, R, Rami-Merhar, B, Johansen, A, Dahl-Jørgensen, K, Clements, M & Hanas, R 2018, ' Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries : A Cross-Sectional Analysis of 64,666 Children and Adolescents With Type 1 Diabetes ', Diabetes Care, vol. 41, no. 6, pp. 1180-1187 . https://doi.org/10.2337/dc17-2271

OBJECTIVE International studies on childhood type 1 diabetes (T1D) have focused on whole-country mean HbA1c levels, thereby concealing potential variations within countries. We aimed to explore the variations in HbA1c across and within eight high-inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323035aa71873eb4a554d7746e269673
https://doi.org/10.2337/dc17-2271

Metformin in adults with type 1 diabetes

Autor: Petrie, John R., Chaturvedi, Nish, Ford, Ian, Hramiak, Irene, Hughes, Alun D., Jenkins, Alicia J., E. Klein, Barbara, Klein, Ron, Ooi, Teik Chye, Rossing, Peter, Sattar, Naveed, Stehouwer, Coen D. A., Colhoun, Helen M., Ford, I, Kean, S, Thomson, E, Gillespie, L, Gibb, J, Greenlaw, N, Hramiak, I, Keech, A, Jenkins, A, Chaturvedi, N, Hughes, A, March, K, Coady, E, Tillin, T, Bots, M, Klein, R, Klein, B, Dreyer, J, Jan, T, Meuer, S, Murach, D, Sheffy, Koby, Lusky, Ravit, Peleg, S, Petrie, J, Colhoun, H, Shore, A, Carty, D, Donnan, P, Witham, M, Adler, A, Lonn, E, Rauchhaus, P, Lindsay, R, Brouwers, M, Van‐Melckebeke, J, Hamill, T, Cuthbertson, L, Murray, A, Jolly, L, Miller, E, Sattar, N, Hair, J, Bell, A, Carmichael, S, Douglas, E, Surtees, P, Dinnett, E, Allan, J, Watson, C, McLaughlin, M, Brindley, G, Smillie, E, Motherwell, D, MacDonald, S, Ellis, P, Stuart, D, Travers, M, Brearley, S, Greig, L, Haw, J

Publikováno v: Petrie, J R, Chaturvedi, N, Ford, I, Hramiak, I, Hughes, A D, Jenkins, A J, E Klein, B, Klein, R, Ooi, T C, Rossing, P, Sattar, N, Stehouwer, C D A, Colhoun, H M & REMOVAL Trial Team 2017, ' Metformin in adults with type 1 diabetes : Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial ', Diabetes, Obesity and Metabolism, vol. 19, no. 4, pp. 509-516 . https://doi.org/10.1111/dom.12840
Diabetes, Obesity & Metabolism, 19(4), 509. Wiley-Blackwell
2017, ' Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial ', Diabetes, Obesity and Metabolism, vol. 19, no. 4 . https://doi.org/10.1111/dom.12840
Diabetes, Obesity & Metabolism
Diabetes Obesity & Metabolism, 19(4), 509-516. Wiley

Aims: Cardiovascular (CV) disease is a major cause of reduced life expectancy in type 1 diabetes (T1D). Intensive insulin therapy prevents CV complications but is constrained by hypoglycaemia and weight gain. Adjunct metformin reduces insulin dose re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1583f76dc0554458a6aba960a7f38de8
https://doi.org/10.1111/dom.12840

Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children

Autor: Cindy Soendersoe Knudsen, Agnes Ziobrowska-Bech, Britta Kremke, Anne Winther-Larsen, Tina Parkner

Publikováno v: Ziobrowska-Bech, A, Winther-Larsen, A, Kremke, B, Parkner, T & Soendersoe Knudsen, C 2019, ' Reference limits for GAD65 and IA-2 autoantibodies by chemiluminescence immunoassay in Northern European adults and children ', Scandinavian Journal of Clinical and Laboratory Investigation, vol. 79, no. 1-2, pp. 123-125 . https://doi.org/10.1080/00365513.2019.1566566

The GAD65 and IA-2 antibodies (Abs) are biomarkers of the development of type 1 diabetes mellitus (T1DM) in both children and adults. The upper reference limit for the autoantibodies made by the manufacture was established on an adult Chinese populat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616b46c7ded559cbb1d0df8f9643549e
https://pubmed.ncbi.nlm.nih.gov/30727763