Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates.

Autor: Zohar T; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Hsiao JC; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Mehta N; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Das J; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Devadhasan A; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Karpinski W; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA., Callahan C; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Citron MP; Merck & Co., Inc., Kenilworth, NJ 07033, USA., DiStefano DJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Touch S; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Wen Z; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Sachs JR; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Cejas PJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Espeseth AS; Merck & Co., Inc., Kenilworth, NJ 07033, USA., Lauffenburger DA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bett AJ; Merck & Co., Inc., Kenilworth, NJ 07033, USA. Electronic address: andrew_bett@merck.com., Alter G; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: galter@mgh.harvard.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2022 Jan 12; Vol. 30 (1), pp. 41-52.e5. Date of Electronic Publication: 2021 Dec 07.

A potent broadly neutralizing human RSV antibody targets conserved site IV of the fusion glycoprotein.

Autor: Tang A; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Chen Z; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Cox KS; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Su HP; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA., Callahan C; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Fridman A; Department of Scientific Informatics, Merck & Co., Inc., Rahway, NJ, USA., Zhang L; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Patel SB; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA., Cejas PJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Swoyer R; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Touch S; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Citron MP; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Govindarajan D; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.; Janssen Research & Development, 1400 McKean Road, Ambler, PA, 19002, USA., Luo B; Department of Pharmacology, Merck & Co., Inc., West Point, PA, USA., Eddins M; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA., Reid JC; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA., Soisson SM; Department of Structural Chemistry and Chemical Biotechnology, Merck & Co., Inc, West Point, PA, USA., Galli J; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Wang D; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Wen Z; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Heidecker GJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Casimiro DR; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA.; Sanofi Pasteur, 1 Discovery Drive, Swiftwater, PA, 18370, USA., DiStefano DJ; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA., Vora KA; Department of Infectious Diseases and Vaccines Research, Merck & Co., Inc, West Point, PA, USA. kalpit.vora@merck.com.

Publikováno v: Nature communications [Nat Commun] 2019 Sep 12; Vol. 10 (1), pp. 4153. Date of Electronic Publication: 2019 Sep 12.

Respiratory syncytial virus elicits enriched CD8+ T lymphocyte responses in lung compared with blood in African green monkeys.

Autor: Li H; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Callahan C; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Citron M; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Wen Z; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Touch S; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Monslow MA; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Cox KS; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., DiStefano DJ; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Vora KA; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Bett A; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America., Espeseth A; Department of Infectious Diseases and Vaccines, MRL, Merck & Co., Inc., West Point, PA, United States of America.

Publikováno v: PloS one [PLoS One] 2017 Nov 09; Vol. 12 (11), pp. e0187642. Date of Electronic Publication: 2017 Nov 09 (Print Publication: 2017).