Differential lipid analysis of oxaliplatin-sensitive and resistant HCT116 cells reveals different levels of drug-induced lipid droplet formation.

Autor: Larson, Tyler S.¹ (AUTHOR), DiProspero, Thomas J.¹ (AUTHOR), Glish, Gary L.¹ (AUTHOR) glish@unc.edu, Lockett, Matthew R.^1,2 (AUTHOR) mlockett@unc.edu

Publikováno v: Analytical & Bioanalytical Chemistry. Jan2024, Vol. 416 Issue 1, p151-162. 12p.

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Evaluating the Impact of Physiologically Relevant Oxygen Tensions on Drug Metabolism in 3D Hepatocyte Cultures in Paper Scaffolds.

Autor: Sitte, Zachary R., DiProspero, Thomas J., Lockett, Matthew R.

Publikováno v: Current Protocols; Feb2023, Vol. 3 Issue 2, p1-30, 30p

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HepaRG cells undergo increased levels of post-differentiation patterning in physiologic conditions when maintained as 3D cultures in paper-based scaffolds.

Autor: Diprospero TJ; Department of Chemistry, University of North Carolina at Chapel Hill, Kenan and Caudill Laboratories, Chapel Hill, NC 27599-3290, United States., Brown LG; Department of Chemistry, University of North Carolina at Chapel Hill, Kenan and Caudill Laboratories, Chapel Hill, NC 27599-3290, United States., Fachko TD; Department of Chemistry, University of North Carolina at Chapel Hill, Kenan and Caudill Laboratories, Chapel Hill, NC 27599-3290, United States., Lockett MR; Department of Chemistry, University of North Carolina at Chapel Hill, Kenan and Caudill Laboratories, Chapel Hill, NC 27599-3290, United States.; Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 37599-7295, United States.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 19. Date of Electronic Publication: 2023 Jan 19.