Quadriparesis and paraparesis following chimeric antigen receptor T-cell therapy in children and adolescents.

Autor: Diorio C; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Hernandez-Miyares L; Division of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Espinoza DA; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Banwell BL; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Division of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Bar-Or A; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Center for Neuroinflammation and Experimental Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., DiNofia AM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Barz Leahy A; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Martinez Z; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Myers RM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Hopkins SE; Division of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Rheingold SR; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Teachey DT; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Viaene AN; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Wray LM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Maude SL; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Grupp SA; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Susan S. and Stephen P. Kelly Center for Cancer Immunotherapy, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., McGuire JL; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Division of Neurology, Departments of Neurology and Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Publikováno v: Blood [Blood] 2024 Sep 26; Vol. 144 (13), pp. 1387-1398.

Comprehensive Serum Proteome Profiling of Cytokine Release Syndrome and Immune Effector Cell-Associated Neurotoxicity Syndrome Patients with B-Cell ALL Receiving CAR T19.

Autor: Diorio C; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Shraim R; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Pennsylvania., Myers R; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Behrens EM; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Canna S; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Rheumatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Bassiri H; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Aplenc R; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Burudpakdee C; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Chen F; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., DiNofia AM; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Gill S; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Gonzalez V; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Lambert MP; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Hematology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Leahy AB; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Levine BL; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Lindell RB; Division of Critical Care Medicine, Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Maude SL; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Melenhorst JJ; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Newman H; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Perazzelli J; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Seif AE; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Lacey SF; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., June CH; Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Barrett DM; Tmunity Therapeutics, Philadelphia, Pennsylvania., Grupp SA; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania., Teachey DT; Immune Dysregulation Frontier Program, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.; Division of Oncology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Sep 01; Vol. 28 (17), pp. 3804-3813.

Identifying relapses and stem cell transplants in pediatric acute lymphoblastic leukemia using administrative data: Capturing national outcomes irrespective of trial enrollment.

Autor: Cahen VC; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Li Y; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania., Getz KD; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Elgarten CW; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., DiNofia AM; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania., Wilkes JJ; Division of Hematology/Oncology, Seattle Children's Hospital and the Department of Pediatrics, University of Washington, Seattle, Washington., Winestone LE; Division of Blood and Marrow Transplantation, UCSF Benioff Children's Hospital, University of California - San Francisco, San Francisco, California., Huang YV; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Miller TP; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.; Department of Pediatrics, Emory University, Atlanta, Georgia., Gramatges MM; Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Rabin KR; Division of Hematology-Oncology, Department of Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, Texas., Fisher BT; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Division of Infectious Diseases, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Aplenc R; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania., Seif AE; Center for Childhood Cancer Research, Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.; Department of Pediatrics, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania.; Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

Publikováno v: Pediatric blood & cancer [Pediatr Blood Cancer] 2021 Sep; Vol. 68 (9), pp. e28315. Date of Electronic Publication: 2020 May 11.

Will allogeneic CAR T cells for CD19 ⁺ malignancies take autologous CAR T cells 'off the shelf'?

Autor: DiNofia AM; Cancer Immunotherapy Program, Cellular Therapy and Transplant Section, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Division of Oncology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Grupp SA; Cancer Immunotherapy Program, Cellular Therapy and Transplant Section, Children's Hospital of Philadelphia, Philadelphia, PA, USA. grupp@chop.edu.; Division of Oncology, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. grupp@chop.edu.

Publikováno v: Nature reviews. Clinical oncology [Nat Rev Clin Oncol] 2021 Apr; Vol. 18 (4), pp. 195-196.

Diagnostic biomarkers to differentiate sepsis from cytokine release syndrome in critically ill children.

Autor: Diorio C; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics., Shaw PA; Department of Biostatistics, Epidemiology, and Informatics., Pequignot E; Center for Cellular Immunotherapies., Orlenko A; Department of Biostatistics, Epidemiology, and Informatics., Chen F; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Aplenc R; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics.; Abramson Cancer Center, and., Barrett DM; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics., Bassiri H; Division of Infectious Diseases and., Behrens E; Department of Pediatrics.; Division of Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA., DiNofia AM; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics., Gonzalez V; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Koterba N; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Levine BL; Department of Biostatistics, Epidemiology, and Informatics.; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Maude SL; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics., Meyer NJ; Division of Pulmonary and Critical Care Medicine, and., Moore JH; Department of Biostatistics, Epidemiology, and Informatics., Paessler M; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Porter DL; Abramson Cancer Center, and.; Division of Hematology-Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Bush JL; Division of Critical Care Medicine and., Siegel DL; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Davis MM; Center for Cellular Immunotherapies., Zhang D; Division of Critical Care Medicine and., June CH; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Grupp SA; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics.; Abramson Cancer Center, and., Melenhorst JJ; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Lacey SF; Center for Cellular Immunotherapies.; Abramson Cancer Center, and.; Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA., Weiss SL; Division of Critical Care Medicine and.; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.; Center for Mitochondrial and Epigenomic Medicine at the Children's Hospital of Philadelphia, Philadelphia, PA; and.; Pediatric Sepsis Program at the Children's Hospital of Philadelphia, Philadelphia, PA., Teachey DT; Division of Hematology and Oncology, Children's Hospital of Philadelphia, Philadelphia, PA.; Department of Pediatrics.; Abramson Cancer Center, and.

Publikováno v: Blood advances [Blood Adv] 2020 Oct 27; Vol. 4 (20), pp. 5174-5183.