Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.

Autor: Razvi E; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., DiFrancesco BR; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Wasney GA; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; The Structural & Biophysical Core Facility, The Hospital for Sick Children, Toronto, Ontario, Canada., Morrison ZA; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Tam J; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Auger A; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; SPARC BioCentre, The Hospital for Sick Children, Toronto, Ontario, Canada., Baker P; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Alnabelseya N; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Rich JD; Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada., Sivarajah P; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada., Whitfield GB; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Harrison JJ; Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada., Melnyk RA; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada., Nitz M; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada., Howell PL; Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Microbiology spectrum [Microbiol Spectr] 2023 Jun 15; Vol. 11 (3), pp. e0029623. Date of Electronic Publication: 2023 Apr 26.

Monosaccharide inhibitors targeting carbohydrate esterase family 4 de-N-acetylases.

Autor: DiFrancesco BR; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Morrison ZA; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada., Nitz M; Department of Chemistry, University of Toronto, Toronto, ON M5S 3H6, Canada. Electronic address: mnitz@chem.utoronto.ca.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2018 Nov 15; Vol. 26 (21), pp. 5631-5643. Date of Electronic Publication: 2018 Oct 12.

Modification and periplasmic translocation of the biofilm exopolysaccharide poly-β-1,6-N-acetyl-D-glucosamine.

Autor: Little DJ; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8;, Li G; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8;, Ing C; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8;, DiFrancesco BR; Department of Chemistry, University of Toronto, Toronto, ON, Canada M5S 3H6; and., Bamford NC; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8;, Robinson H; Photon Sciences Division, Brookhaven National Laboratory, Upton, NY 11973-5000., Nitz M; Department of Chemistry, University of Toronto, Toronto, ON, Canada M5S 3H6; and howell@sickkids.ca mnitz@chem.utoronto.ca pomes@sickkids.ca., Pomès R; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8; howell@sickkids.ca mnitz@chem.utoronto.ca pomes@sickkids.ca., Howell PL; Program in Molecular Structure and Function, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada M5G 1X8;Department of Biochemistry, University of Toronto, Toronto, ON, Canada M5S 1A8; howell@sickkids.ca mnitz@chem.utoronto.ca pomes@sickkids.ca.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Jul 29; Vol. 111 (30), pp. 11013-8. Date of Electronic Publication: 2014 Jul 03.

Discovery of a novel class of aldol-derived 1,2,3-triazoles: potent and selective inhibitors of human cytochrome P450 19A1 (aromatase).

Autor: McNulty J; Department of Chemistry and Chemical Biology, McMaster University, 1280 Main Street West, Hamilton, Ont., Canada L8S 4M1. jmcnult@mcmaster.ca, Nair JJ, Vurgun N, Difrancesco BR, Brown CE, Tsoi B, Crankshaw DJ, Holloway AC

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Jan 01; Vol. 22 (1), pp. 718-22. Date of Electronic Publication: 2011 Oct 20.