Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function

Autor: Heathfield, Sarah, Parker, Ben, Zeef, Leo, Bruce, Ian, Alexander, Yvonne, Collins, Fraser, Stone, Michael, Wang, Edward, Williams, Anwen S., Wright, Helen L., Thomas, Huw B., Moots, Robert J., Edwards, Steven W., Bullock, Craig, Chapman, Victoria, Walsh, David A., Mobasheri, Ali, Kendall, David, Kelly, Sara, Bayley, Rachel, Buckley, Chris D., Young, Stephen P., Rump-Goodrich, Lisa, Middleton, Jim, Chen, Liye, Fisher, Roman, Kollnberger, Simon, Shastri, Nilabh, Kessler, Benedikt M., Bowness, Paul, Nazeer Moideen, Abdul, Evans, Laura, Osgood, Louise, Jones, Simon A., Nowell, Mari A., Mahadik, Younis, Young, Stephen, Morgan, Matthew, Gordon, Caroline, Harper, Lorraine, Giles, Joanna L., Paul Morgan, B., Harris, Claire L., Rysnik, Oliwia J., McHugh, Kirsty, Payeli, Sravan, Marroquin, Osiris, Shaw, Jacqueline, Renner, Christoph, Nayar, Saba, Cloake, Tom, Bombardieri, Michele, Pitzalis, Costantino, Buckley, Chris, Barone, Francesca, Lane, Peter, Coles, Mark, Williams, Emma L., Edwards, Christopher J., Cooper, Cyrus, Oreffo, Richard O., Dunn, Sara, Crawford, Aileen, Wilkinson, Mark, Le Maitre, Christine, Bunning, Rowena, Daniels, Jodie, Phillips, Kate L. E., Chiverton, Neil, Le Maitre, Christine L., Shaw, Jackie, Ridley, Anna, Wong-Baeza, Isabel, Keidel, Sarah, Chan, Antoni, Gullick, Nicola J., Abozaid, Hanan S., Jayaraj, David M., Evans, Hayley G., Scott, David L., Choy, Ernest H., Taams, Leonie S., Hickling, M., Golor, G., Jullion, A., Shaw, S., Kretsos, K., Bari, Syed F., Rhys-Dillon, Brian, Amos, Nicholson, Siebert, Stefan, Bunning, Rowena D., Haddock, Gail, Cross, Alison K., Kate, I., Phillips, E., Cross, Alison, Bunning, Rowena A. D., Ceeraz, Sabrina, Spencer, Jo, Choy, Ernest, Corrigall, Valerie, Crilly, Anne, Palmer, Helen, Lockhart, John, Plevin, Robin, Ferrell, William R., McInnes, Iain, Hutchinson, David, Perry, Liz, DiCicco, Maria, Humby, Frances, Kelly, Stephen, Hands, Rebecca, McInnes, Ian, Taylor, Peter, Mehta, Puja, Mitchell, Adam, Tysoe, Carolyn, Caswell, Richard, Owens, Martina, Vincent, Tonia, Hashmi, Tahir M., Price-Forbes, Alec, Sharp, Charlotte A., Murphy, Helen, Wood, Elizabeth F., Doherty, Teresa, Sheldon, Jo, Sofat, Nidhi, Goff, Iain, Platt, Philip N., Abdulkader, Rita, Clunie, Gavin, Ismajli, Mediola, Nikiphorou, Elena, Young, Adam, Tugnet, Nicola, Dixey, Josh, Banik, Snehashish, Alcorn, Desmond, Hunter, John, Win Maw, Win, Patil, Pravin, Hayes, Fiona, Main Wong, Way, Borg, Frances A., Dasgupta, Bhaskar, Malaviya, Anshuman P., Ostor, Andrew J., Chana, Jasroop K., Ahmed, Azeem A., Edmonds, Sally, Coward, Lucy, Borg, Frances, Heaney, Jonathan, Amft, Nicole, Simpson, John, Dhillon, Veena, Ayalew, Yezenash, Khattak, Fazlihakim, Gayed, Mary, Amarasena, Roshan I., McKenna, Frank, Mc Laughlin, Maeve, Baburaj, Krishnan, Fattah, Zozik, Ng, Nora, Wilson, Jo, Colaco, Bernard, Williams, Mark R., Adizie, Tochukwu, Casey, Matthew, Lip, Stefanie, Tan, Shaun, Anderson, David, Robertson, Calum, Devanny, Ian, Field, Max, Walker, David, Robinson, Sandra, Ryan, Sarah, Hassell, Andrew, Bateman, James, Allen, Maggie, Davies, David, Crouch, Carina, Walker-Bone, Karen, Gainsborough, Nicola, Lutalo, Pamela M., Davies, Ursula M., Mckew, Jennifer R., Millar, Auleen M., Wright, Stephen A., Bell, Aubrey L., Thapper, Muryum, Roussou, Thalia, Cumming, Jo, Hull, Richard G., McKeogh, John, O'Connor, Mortimer B., Hassan, Ahmed I., Bond, Ursula, Swan, Joan, Phelan, Mark J., Coady, David, Kumar, Namita, Farrow, Luke, Bukhari, Marwan, Oldroyd, Alexander G., Greenbank, Cathi, McBeth, John, Duncan, Rosie, Brown, Deborah, Horan, Michael, Pendleton, Neil, Littlewood, Alison, Cordingley, Lis, Mulvey, Matthew, Curtis, Elizabeth M., Cole, Zoe A., Crozier, Sarah R., Georgia, Ntani, Robinson, Siân M., Godfrey, Keith M., Sayer, Avan A., Inskip, Hazel M., Harvey, Nicholas C., Davies, Rebecca, Mercer, Louise, Galloway, James, Low, Audrey, Watson, Kath, Lunt, Mark, Symmons, Deborah, Hyrich, Kimme, Chitale, Sarang, Estrach, Cristina, Goodson, Nicola J., Rankin, Elizabeth, Jiang, C. 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M., Bacon, Paul A., Mackie, Sarah L.

Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______805::a4b06c273877b5e058c41856225cd811
http://doc.rero.ch/record/300068/files/kes108.pdf

Angiogenic gene expression and vascular density are reflected in ultrasonographic features of synovitis in early rheumatoid arthritis: an observational study.

Autor: Kelly, Stephen, Bombardieri, Michele, Humby, Frances, Ng, Nora, Marrelli, Alessandra, Riahi, Sudeh, DiCicco, Maria, Mahto, Arti, Lu Zou, Pyne, Debasish, Hands, Rebecca E., Pitzalis, Costantino

Publikováno v: Arthritis Research & Therapy; 2015, Vol. 17 Issue 1, p1-10, 10p

Carotid plaque area: a tool for targeting and evaluating vascular preventive therapy.

Autor: Spence, J David, Eliasziw, Michael, DiCicco, Maria, Hackam, Daniel G, Galil, Ramzy, Lohmann, Tara

Publikováno v: Stroke (00392499); 2002 Dec, Vol. 33 Issue 12, p2916-2922, 7p

Molecular Portraits of Early Rheumatoid Arthritis Identify Clinical and Treatment Response Phenotypes

Autor: Lewis, Myles J., Barnes, Michael R., Blighe, Kevin, Goldmann, Katriona, Rana, Sharmila, Hackney, Jason A., Ramamoorthi, Nandhini, John, Christopher R., Watson, David S., Kummerfeld, Sarah K., Hands, Rebecca, Riahi, Sudeh, Rocher-Ros, Vidalba, Rivellese, Felice, Humby, Frances, Kelly, Stephen, Bombardieri, Michele, Ng, Nora, DiCicco, Maria, van der Heijde, Désirée, Landewé, Robert, van der Helm-van Mil, Annette, Cauli, Alberto, McInnes, Iain B., Buckley, Christopher D., Choy, Ernest, Taylor, Peter C., Townsend, Michael J., Pitzalis, Costantino

Publikováno v: Cell Reports; August 2019, Vol. 28 Issue: 9 p2455-2470.e5

Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients.

Autor: Humby F; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Lewis M; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Ramamoorthi N; Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA., Hackney JA; Bioinformatics and Computational Biology, Genentech Inc, South San Francisco, California, USA., Barnes MR; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.; Centre for Translational Bioinformatics, William Harvey Research Institute, London, UK., Bombardieri M; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Setiadi AF; Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA., Kelly S; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Bene F; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., DiCicco M; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Riahi S; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Rocher V; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Ng N; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Lazarou I; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Hands R; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., van der Heijde D; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Landewé RBM; Amsterdam Rheumatology Center, AMC, Amsterdam, Netherlands.; Department of Rheumatology, Zuyderland MC, Heerlen, Netherlands., van der Helm-van Mil A; Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands., Cauli A; Universita degli Studi di Cagliari, Cagliari, Italy., McInnes I; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK., Buckley CD; University of Birmingham, Birmingham, UK., Choy EH; Institute of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK., Taylor PC; Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, Oxford, UK., Townsend MJ; Biomarker Discovery OMNI, Genentech Inc, South San Francisco, California, USA c.pitzalis@qmul.ac.uk townsend.michael@gene.com., Pitzalis C; Centre for Experimental Medicine & Rheumatology, William Harvey Research Institute, Barts & The London School of Medicine & Dentistry, Queen Mary University of London, London, UK c.pitzalis@qmul.ac.uk townsend.michael@gene.com.

Publikováno v: Annals of the rheumatic diseases [Ann Rheum Dis] 2019 Jun; Vol. 78 (6), pp. 761-772. Date of Electronic Publication: 2019 Mar 16.