The mechanisms of in vivo commensal control of Clostridioides difficile virulence

Autor: Girinathan, BP, DiBenedetto, N, Worley, J, Peltier, J, Lavin, R, Delaney, ML, Cummins, C, Onderdonk, AB, Gerber, GK, Dupuy, B, Sonenshein, AL, Bry, L

We define multiple mechanisms by which commensals protect against or worsen Clostridioides difficile infection. Using a systems-level approach we show how two species of Clostridia with distinct metabolic capabilities modulate the pathogen’s virule

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::b7b346bf34827421822aa5ecac982114

In vivo commensal control of Clostridioides difficile virulence.

Autor: Girinathan BP; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., DiBenedetto N; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Worley JN; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; National Center of Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA., Peltier J; Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, UMR CNRS 2001, Université de Paris, 25-28 Rue du Dr. Roux, Institut Pasteur, 75015 Paris Cedex, France; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Saclay, 91198, Gif-sur-yvette Cedex, France., Arrieta-Ortiz ML; Institute for Systems Biology, Seattle, WA 98109, USA., Immanuel SRC; Institute for Systems Biology, Seattle, WA 98109, USA., Lavin R; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Delaney ML; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA., Cummins CK; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Hoffman M; Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Department of Microbiology, College Park, MD 20740, USA., Luo Y; Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Department of Microbiology, College Park, MD 20740, USA., Gonzalez-Escalona N; Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Department of Microbiology, College Park, MD 20740, USA., Allard M; Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Department of Microbiology, College Park, MD 20740, USA., Onderdonk AB; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA., Gerber GK; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Harvard-MIT Health Sciences & Technology, Cambridge, MA 02139, USA., Sonenshein AL; Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111, USA., Baliga NS; Institute for Systems Biology, Seattle, WA 98109, USA., Dupuy B; Laboratoire Pathogenèse des Bactéries Anaérobies, Institut Pasteur, UMR CNRS 2001, Université de Paris, 25-28 Rue du Dr. Roux, Institut Pasteur, 75015 Paris Cedex, France., Bry L; Massachusetts Host-Microbiome Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Clinical Microbiology Laboratory, Department of Pathology, Brigham & Women's Hospital, Boston, MA 02115, USA. Electronic address: lbry@bwh.harvard.edu.

Publikováno v: Cell host & microbe [Cell Host Microbe] 2021 Nov 10; Vol. 29 (11), pp. 1693-1708.e7. Date of Electronic Publication: 2021 Oct 11.

Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model.

Autor: Neto CC; Department of Chemistry and Biochemistry University of Massachusetts Dartmouth, North Dartmouth, MA.; UMass Cranberry Health Research Center, University of Massachusetts Dartmouth, North Dartmouth, MA., Mortzfeld BM; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA., Turbitt JR; Department of Chemistry and Biochemistry University of Massachusetts Dartmouth, North Dartmouth, MA.; UMass Cranberry Health Research Center, University of Massachusetts Dartmouth, North Dartmouth, MA., Bhattarai SK; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA., Yeliseyev V; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA., DiBenedetto N; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA., Bry L; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston MA., Bucci V; UMass Cranberry Health Research Center, University of Massachusetts Dartmouth, North Dartmouth, MA.; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA.

Publikováno v: Microbial cell (Graz, Austria) [Microb Cell] 2021 Apr 29; Vol. 8 (6), pp. 131-142. Date of Electronic Publication: 2021 Apr 29.

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Microbiota therapy acts via a regulatory T cell MyD88/RORγt pathway to suppress food allergy.

Autor: Abdel-Gadir A; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Stephen-Victor E; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Gerber GK; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Noval Rivas M; Division of Pediatric Infectious Diseases and Immunology, Department of Pediatrics, Infectious and Immunologic Diseases Research Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Wang S; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Harb H; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Wang L; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Li N; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Crestani E; Division of Immunology, Boston Children's Hospital, Boston, MA, USA.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA., Spielman S; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Secor W; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., Biehl H; Division of Immunology, Boston Children's Hospital, Boston, MA, USA., DiBenedetto N; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Dong X; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Umetsu DT; Genentech, South San Francisco, CA, USA., Bry L; Massachusetts Host-Microbiome Center, Department of Pathology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA., Rachid R; Division of Immunology, Boston Children's Hospital, Boston, MA, USA. Rima.Rachid@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Rima.Rachid@childrens.harvard.edu., Chatila TA; Division of Immunology, Boston Children's Hospital, Boston, MA, USA. Talal.chatila@childrens.harvard.edu.; Department of Pediatrics, Harvard Medical School, Boston, MA, USA. Talal.chatila@childrens.harvard.edu.

Publikováno v: Nature medicine [Nat Med] 2019 Jul; Vol. 25 (7), pp. 1164-1174. Date of Electronic Publication: 2019 Jun 24.