Relative adrenal insufficiency in mice deficient in 5α-reductase 1

Autor: Livingstone, Dawn E W, Di Rollo, Emma M, Yang, Chenjing, Codrington, Lucy E, Mathews, John A, Kara, Madina, Hughes, Katherine A, Kenyon, Christopher J, Walker, Brian R, Andrew, Ruth

Publikováno v: Livingstone, D E W, Di Rollo, E M, Yang, C, Codrington, L E, Mathews, J A, Kara, M, Hughes, K A, Kenyon, C J, Walker, B R & Andrew, R 2014, ' Relative adrenal insufficiency in mice deficient in 5α-reductase 1 ', Journal of Endocrinology, vol. 222, no. 2, pp. 257-266 . https://doi.org/10.1530/JOE-13-0563

Patients with critical illness or hepatic failure exhibit impaired cortisol responses to ACTH, a phenomenon known as 'relative adrenal insufficiency'. A putative mechanism is that elevated bile acids inhibit inactivation of cortisol in liver by 5α-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::5776e7ba35cd7f92cd1b97fd17df6573
https://hdl.handle.net/20.500.11820/5327d979-3746-4b7c-929d-0c749dd6fea6

Metabolic dysfunction in female mice with disruption of 5a-reductase 1.

Autor: Livingstone, Dawn E. W., Di Rollo, Emma M., Mak, Tracy C-S, Sooy, Karen, Walker, Brian R., Andrew, Ruth

Publikováno v: Journal of Endocrinology; Jan2017, Vol. 232 Issue 1, p29-36, 8p

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Role of 5α-reductase type 1 in modifying anxiety, appetite and the HPA axis

Autor: Di Rollo, Emma Margaret

Glucocorticoid excess is associated with adverse effects on a number of physiological parameters, leading to obesity, dysfunction of the hypothalamic-pituitary- adrenal (HPA) axis and behavioural changes such as anxiety and impaired learning and memo

Externí odkaz: http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.685753