Targeting hepcidin in colorectal cancer triggers a TNF-dependent-gasdermin E-driven immunogenic cell death response.

Autor: Di Grazia A; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Franzè E; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Frascatani R; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Laudisi F; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Pacifico T; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Tomassini L; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Di Fusco D; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Formica V; Medical Oncology Unit, Fondazione Policlinico 'Tor Vergata', Rome, Italy., Sica G; Department of Surgery, University Rome of 'Tor Vergata', Rome, Italy., Stolfi C; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy., Monteleone G; Department of Systems Medicine, University of Rome 'Tor Vergata', Via Montpellier, 1, 00133, Rome, Italy. Gi.Monteleone@Med.uniroma2.it.; Gastroenterology Unit, Fondazione Policlinico 'Tor Vergata', Rome, Italy. Gi.Monteleone@Med.uniroma2.it.

Publikováno v: Experimental hematology & oncology [Exp Hematol Oncol] 2024 Sep 27; Vol. 13 (1), pp. 95. Date of Electronic Publication: 2024 Sep 27.

Characterization of a novel IDH2-R159H mutation in acute myeloid leukaemia: Effects on cell metabolism and differentiation.

Autor: Nardozza AM; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Guarnera L; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Travaglini S; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Ottone T; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.; Neuro-Oncohematology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Divona M; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.; UniCamillus-Saint Camillus International University of Health Sciences, Rome, Italy., De Bellis E; Department of Biomedicine and Prevention, PhD in Immunology, Molecular Medicine and Applied Biotechnology, University of Rome Tor Vergata, Rome, Italy.; SC Ematologia, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy., Savi A; Department of clinical and biological sciences, University of Turin, Turin, Italy., Banella C; Neuro-Oncohematology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Noguera NI; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.; Neuro-Oncohematology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy., Di Fusco D; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy., Voso MT; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.; Neuro-Oncohematology Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.

Publikováno v: British journal of haematology [Br J Haematol] 2024 Feb; Vol. 204 (2), pp. 719-723. Date of Electronic Publication: 2023 Nov 27.

Insulin-like Growth Factor II mRNA-Binding Protein 1 Regulates Pancreatic Cancer Cell Growth through the Surveillance of CDC25A mRNA.

Autor: Di Fusco D; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Segreto MT; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Di Maggio G; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Iannucci A; Department of Biomedicine and Prevention, University of 'Tor Vergata', 00133 Rome, Italy., Maresca C; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Di Grazia A; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Colella M; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Stolfi C; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Monteleone G; Department of Systems Medicine, University of 'Tor Vergata', 00133 Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of 'Tor Vergata', 00133 Rome, Italy.

Publikováno v: Cancers [Cancers (Basel)] 2023 Oct 13; Vol. 15 (20). Date of Electronic Publication: 2023 Oct 13.

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Rafoxanide sensitizes colorectal cancer cells to TRAIL-mediated apoptosis.

Autor: Laudisi F; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Pacifico T; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Maresca C; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Luiz-Ferreira A; Inflammatory Bowel Disease Research Laboratory, Department of Biological Sciences, Institute of Biotechnology, Federal University of Catalão (UFCAT), Catalão, GO, Brazil., Antonelli S; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Ortenzi A; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Colantoni A; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Di Grazia A; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Franzè E; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Colella M; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Di Fusco D; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Sica GS; Department of Surgery, University of Rome 'Tor Vergata', Rome, Italy., Monteleone I; Department of Biomedicine and Prevention, University of Rome 'Tor Vergata', Rome, Italy., Monteleone G; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy., Stolfi C; Department of Systems Medicine, University of Rome 'Tor Vergata', Rome, Italy. Electronic address: carmine.stolfi@uniroma2.it.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Nov; Vol. 155, pp. 113794. Date of Electronic Publication: 2022 Oct 04.