IL-9 sensitizes human Th2 cells to pro-inflammatory IL-18 signals in atopic dermatitis.

Autor: Schärli S; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Luther F; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Di Domizio J; Department of Dermatology, CHUV University Hospital, University of Lausanne, Lausanne, Switzerland., Hillig C; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany., Radonjic-Hoesli S; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Thormann K; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Simon D; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Møller Rønnstad AT; Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark., Ruge IF; Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark., Fritz BG; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark., Bjarnsholt T; Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Vallone A; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Kezic S; Department of Public and Occupational Health, Amsterdam University Medical Center, University of Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, Netherlands., Menden MP; Institute of Computational Biology, Helmholtz Center Munich, Neuherberg, Germany; Department of Biochemistry and Pharmacology, University of Melbourne, Parkville, Australia., Roesner LM; Department of Dermatology and Allergy, Hannover Medical School (MHH), Hannover, Germany., Werfel T; Department of Dermatology and Allergy, Hannover Medical School (MHH), Hannover, Germany., Thyssen JP; Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark., Eyerich S; Center for Allergy and Environment (ZAUM), Technical University and Helmholtz Center Munich, Munich, Germany., Gilliet M; Department of Dermatology, CHUV University Hospital, University of Lausanne, Lausanne, Switzerland., Bertschi NL; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland., Schlapbach C; Department of Dermatology, Inselspital, Bern University Hospital, Department for BioMedical Research (DBMR), University of Bern, Bern, Switzerland. Electronic address: christoph.schlapbach@insel.ch.

Publikováno v: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2024 Nov 07. Date of Electronic Publication: 2024 Nov 07.

Human neutrophils drive skin autoinflammation by releasing interleukin (IL)-26.

Autor: Baldo A; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Di Domizio J; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Yatim A; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Vandenberghe-Dürr S; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Jenelten R; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Fries A; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Grizzetti L; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Kuonen F; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Paul C; Department of Dermatology and Venereology, Centre Hospitalier Universitaire, Toulouse, France., Modlin RL; Division of Dermatology, University of California, Los Angeles, Los Angeles, CA, USA., Conrad C; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland., Gilliet M; Department of Dermatology and Venereology, University Hospital of Lausanne, Lausanne, Switzerland.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2024 May 06; Vol. 221 (5). Date of Electronic Publication: 2024 Mar 06.

Cross-Comparison of Inflammatory Skin Disease Transcriptomics Identifies PTEN as a Pathogenic Disease Classifier in Cutaneous Lupus Erythematosus.

Autor: Aevermann BD; J. Craig Venter Institute, La Jolla, California, USA; Chan Zuckerberg Initiative, Redwood City, California, USA., Di Domizio J; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Olah P; Department of Dermatology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Saidoune F; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland., Armstrong JM; Galderma, Lausanne, Switzerland., Bachelez H; Department of Dermatology, Paris Diderot University, Paris, France., Barker J; St John's Institute of Dermatology, Faculty of Life Sciences & Medicine, Kings College London, London, United Kingdom., Haniffa M; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle, United Kingdom., Julia V; Galderma, Lausanne, Switzerland., Juul K; LEO Pharma A/S, Ballerup, Denmark., Krishnaswamy JK; Galderma, Lausanne, Switzerland., Litman T; LEO Pharma A/S, Ballerup, Denmark., Parsons I; Celgene International Sarl, Boudry, Switzerland., Sarin KY; Department of Dermatology, Stanford University Medical Center, Palo Alto, California, USA., Schmuth M; Department of Dermatology, Venereology and Allergy, Medical University Innsbruck, Innsbruck, Austria., Sierra M; LEO Pharma A/S, Ballerup, Denmark., Simpson M; Department of Genomic Medicine, King's College London, London, United Kingdom., Homey B; Department of Dermatology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany., Griffiths CEM; Section of Dermatology, Department of Medicine, University of Manchester, Manchester, United Kingdom., Scheuermann RH; J. Craig Venter Institute, La Jolla, California, USA; Department of Pathology, University of California San Diego School of Medicine, La Jolla, California, USA; La Jolla Institute for Immunology, La Jolla, California, USA., Gilliet M; Department of Dermatology, Lausanne University Hospital (CHUV), University of Lausanne, Lausanne, Switzerland. Electronic address: michel.gilliet@chuv.ch.

Publikováno v: The Journal of investigative dermatology [J Invest Dermatol] 2024 Feb; Vol. 144 (2), pp. 252-262.e4. Date of Electronic Publication: 2023 Aug 19.

Activin A-Mediated Polarization of Cancer-Associated Fibroblasts and Macrophages Confers Resistance to Checkpoint Immunotherapy in Skin Cancer.

Autor: Pich-Bavastro C; Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Yerly L; Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Di Domizio J; Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Tissot-Renaud S; Department of Oncology, Immune Landscape Laboratory, Center of Experimental Therapeutics, Lausanne University Hospital, Lausanne, Switzerland.; Ludwig Institute for Cancer Research Lausanne, Lausanne University Hospital and University of Lausanne, Switzerland., Gilliet M; Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Kuonen F; Department of Dermatology and Venereology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Sep 01; Vol. 29 (17), pp. 3498-3513.

Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis.

Autor: Ma F; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109, USA., Plazyo O; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Billi AC; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Tsoi LC; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Xing X; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Wasikowski R; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Gharaee-Kermani M; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Hile G; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Jiang Y; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Harms PW; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA., Xing E; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Kirma J; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Xi J; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Hsu JE; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Sarkar MK; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Chung Y; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Di Domizio J; Department of Dermatology, University Hospital of Lausanne, 1011, Lausanne, Switzerland., Gilliet M; Department of Dermatology, University Hospital of Lausanne, 1011, Lausanne, Switzerland., Ward NL; Department of Dermatology, Case Western Reserve University, Cleveland, OH, 44106, USA., Maverakis E; Department of Dermatology, University of California Davis, Sacramento, CA, USA., Klechevsky E; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Voorhees JJ; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Elder JT; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA.; Ann Arbor Veterans Affairs Medical Center, Ann Arbor, MI, 48105, USA., Lee JH; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, 48109, USA., Kahlenberg JM; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA., Pellegrini M; Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA., Modlin RL; Division of Dermatology, Department of Medicine, University of California, Los Angeles, CA, 90095, USA.; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA., Gudjonsson JE; Department of Dermatology, University of Michigan, Ann Arbor, MI, 48109, USA. johanng@med.umich.edu.

Publikováno v: Nature communications [Nat Commun] 2023 Jun 12; Vol. 14 (1), pp. 3455. Date of Electronic Publication: 2023 Jun 12.