The Crystal Structure of the Complex Between a Disaccharide Anthracycline and the DNA Hexamer d(CGATCG) Reveals two Different Binding Sites Involving two DNA Duplexes

Autor: Temperini C. 1, Messori L. 1, Orioli P. 1, Di Bugno C. 2, Animati F. 2, Ughetto G. 3

Publikováno v: Nucleic acids research 31 (2003): 1464–1469.
info:cnr-pdr/source/autori:Temperini C. 1, Messori L. 1, Orioli P. 1, Di Bugno C. 2, Animati F. 2, Ughetto G. 3/titolo:The Crystal Structure of the Complex Between a Disaccharide Anthracycline and the DNA Hexamer d(CGATCG) Reveals two Different Binding Sites Involving two DNA Duplexes/doi:/rivista:Nucleic acids research/anno:2003/pagina_da:1464/pagina_a:1469/intervallo_pagine:1464–1469/volume:31

The crystal structure of the complex formed between the anthracycline antibiotic MEN 10755, an active disaccharide analogue of doxorubicin, and the DNA hexamer d(CGATCG) has been solved to a resolution of 2.1 Å. MEN 10755 exhibits a broad spectrum o

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https://publications.cnr.it/doc/19564