CRISPR-based gene disruption and integration of high-avidity, WT1-specific T cell receptors improve antitumor T cell function.

Autor: Ruggiero E; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Carnevale E; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Prodeus A; Intellia Therapeutics, Cambridge, MA 02139, USA., Magnani ZI; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Camisa B; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Merelli I; San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.; National Research Council, Institute for Biomedical Technologies, Segrate, Italy., Politano C; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Stasi L; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Potenza A; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.; School of Medicine and Surgery, Milano-Bicocca University, 20126 Milan, Italy., Cianciotti BC; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Manfredi F; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy., Di Bono M; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Vago L; Immunogenetics, Leukemia Genomics and Immunobiology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.; Hematology and Bone Marrow Transplantation Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Tassara M; Immunohematology and Transfusion Medicine Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Mastaglio S; Hematology and Bone Marrow Transplantation Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Ponzoni M; Vita-Salute San Raffaele University, 20132 Milan, Italy.; Pathology Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Sanvito F; Pathology Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Liu D; Intellia Therapeutics, Cambridge, MA 02139, USA., Balwani I; Intellia Therapeutics, Cambridge, MA 02139, USA., Galli R; Neural Stem Cell Biology Unit, Division of Neurosciences, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Genua M; Genomics of the Innate Immune System Unit, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Ostuni R; Vita-Salute San Raffaele University, 20132 Milan, Italy.; Genomics of the Innate Immune System Unit, San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Doglio M; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., O'Connell D; Intellia Therapeutics, Cambridge, MA 02139, USA., Dutta I; Intellia Therapeutics, Cambridge, MA 02139, USA., Yazinski SA; Intellia Therapeutics, Cambridge, MA 02139, USA., McKee M; Intellia Therapeutics, Cambridge, MA 02139, USA., Arredouani MS; Intellia Therapeutics, Cambridge, MA 02139, USA., Schultes B; Intellia Therapeutics, Cambridge, MA 02139, USA., Ciceri F; Vita-Salute San Raffaele University, 20132 Milan, Italy.; Hematology and Bone Marrow Transplantation Unit, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy., Bonini C; Experimental Hematology Unit, Division of Immunology, Transplantation and Infectious Diseases, Ospedale San Raffaele Scientific Institute, 20132 Milan, Italy.; Vita-Salute San Raffaele University, 20132 Milan, Italy.

Publikováno v: Science translational medicine [Sci Transl Med] 2022 Feb 09; Vol. 14 (631), pp. eabg8027. Date of Electronic Publication: 2022 Feb 09.

Toward a scalable multimedia metadata infrastructure using distributed computing and semantic web technologies

Autor: Asirelli P., Di Bono M. G., Martinelli M., Salvetti O., Signore O., Catasta M., Morbidoni C., Piazza F., Tummarello G.

Publikováno v: 2nd European Workshop on the Integration of Knowledge, Semantic and Digital Media Technologies, pp. 153–156, London, 30 November 30-1 December 2005
info:cnr-pdr/source/autori:Asirelli P.; Di Bono M. G.; Martinelli M.; Salvetti O.; Signore O.; Catasta M.; Morbidoni C.; Piazza F.; Tummarello G./congresso_nome:2nd European Workshop on the Integration of Knowledge, Semantic and Digital Media Technologies/congresso_luogo:London/congresso_data:30 November 30-1 December 2005/anno:2005/pagina_da:153/pagina_a:156/intervallo_pagine:153–156

This paper describes a research activity carried on in the frame of a collaboration among ISTI-CNR, leader of the 'Representation and Communication of Data and Metadata' Workpackage in the European Project MUSCLE-NoE('Multimedia Understanding through

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::27b6b7ad3d1cbd4119b13b18de4e62f3
https://openportal.isti.cnr.it/doc?id=people______::27b6b7ad3d1cbd4119b13b18de4e62f3

Disease evolution prognosis based on multi-source signals and image analysis

Autor: Colantonio S., Di Bono M. G., Salvetti O.

Publikováno v: Advanced Information and Telemedicine Technologies for Health, pp. 66, Minsk, November 8-10, 2005
info:cnr-pdr/source/autori:Colantonio S.; Di Bono M.G.; Salvetti O./congresso_nome:Advanced Information and Telemedicine Technologies for Health/congresso_luogo:Minsk/congresso_data:November 8-10, 2005/anno:2005/pagina_da:/pagina_a:66/intervallo_pagine:66

A methodology to approach the automatic monitoring and prognosis of diseases evolution is proposed. We define a multilevel system architecture capable to process multi-source biomedical data according to a coarse-to-fine paradigm. An application rega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2c2e3e3ee14245ec065c80eb9c6dd3aa
http://www.cnr.it/prodotto/i/91185

A two-dimensional wavelet-based approach

Autor: Bozzi E., Cavaccini G., Chimenti M., Di Bono M. G., Salvetti O.

Publikováno v: Pattern recognition and image analysis 15-2 (2005): 516–519.
info:cnr-pdr/source/autori:Bozzi E.; Cavaccini G.; Chimenti M.; Di Bono M.G.; Salvetti O./titolo:A two-dimensional wavelet-based approach/doi:/rivista:Pattern recognition and image analysis/anno:2005/pagina_da:516/pagina_a:519/intervallo_pagine:516–519/volume:15-2

An image processing procedure is proposed to detect porosity defects in composite materials, analyzing C-scan images obtained by ultrasound inspection techniques. An image described by a set of features is analyzed in order to evaluate its similarity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f342acc05d05e92c9adb30c355f9aef
https://publications.cnr.it/doc/68304

Representation and communication of multimedia data and metadata

Autor: Colantonio S., Di Bono M. G., Martinelli M., Pieri G., Salvetti O.

Publikováno v: ERCIM news 62 (2005): 27–30.
info:cnr-pdr/source/autori:Colantonio S.; Di Bono M.G.; Martinelli M.; Pieri G.; Salvetti O./titolo:Representation and communication of multimedia data and metadata/doi:/rivista:ERCIM news/anno:2005/pagina_da:27/pagina_a:30/intervallo_pagine:27–30/volume:62

In recent years the increasing role of Multimedia (MM) data, in the form of still pictures, graphics, 3D models, audio, speech, video or their combination (eg MM presentations), in the real world, has lead to a demand for better procedures for the au

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d8338523c9eb0c7cd017dc4ffdd7e79
https://publications.cnr.it/doc/68317