Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dhvanir Kansara"'
Autor:
Constantine S. Mitsiades, Irene Georgakoudi, Myles Brown, Aedín C. Culhane, Rinath Jeselsohn, Yu Chen, Joseph H. Schwab, Nicholas Mitsiades, Dong Gao, Zhiyi Liu, Pallavi Awate, Shruti Sharma, Xiang Weng, Dhvanir Kansara, Ricardo de Matos Simoes, Eugen Dhimolea
Supplemental Materials & Methods and Figures 1-6. Sup. Figure 1. The effect of antiestrogens against ER+ BrCa spheroid cultures is attenuated by BMSCs. Sup. Figure 2. BMSCs attenuate the antiestrogen response of BrCa xenografts in vivo. Sup. Figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2592e0493168e412c12d5dcb71bf783d
https://doi.org/10.1158/0008-5472.22427449
https://doi.org/10.1158/0008-5472.22427449
Autor:
Constantine S. Mitsiades, Irene Georgakoudi, Myles Brown, Aedín C. Culhane, Rinath Jeselsohn, Yu Chen, Joseph H. Schwab, Nicholas Mitsiades, Dong Gao, Zhiyi Liu, Pallavi Awate, Shruti Sharma, Xiang Weng, Dhvanir Kansara, Ricardo de Matos Simoes, Eugen Dhimolea
Although hormonal therapy (HT) inhibits the growth of hormone receptor–positive (HR+) breast and prostate cancers, HT resistance frequently develops within the complex metastatic microenvironment of the host organ (often the bone), a setting poorly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb0100e3894c340d1a10b497f582e965
https://doi.org/10.1158/0008-5472.c.6512674.v1
https://doi.org/10.1158/0008-5472.c.6512674.v1
Autor:
Eugen Dhimolea, Michal Sheffer, Constantine S. Mitsiades, Myles Brown, Ricardo De Matos Simoes, Juliette Bouyssou, Aedín C. Culhane, Jennifer Roth, Nathanael S. Gray, Dhvanir Kansara, Rinath Jeselsohn, Boris Bartholdy, Ulrich Steidl
Publikováno v:
Cancer Research. 81:GS1-07
Systemic breast cancer treatments often fail to achieve complete and sustained responses due to drug-persistent residual tumor foci, the “seed” for eventual relapse. Recent clinical studies have revealed that the chemo-persistent tumor cells unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5543f5ef938bdec2c527c495f5df2cf4
https://doi.org/10.1158/1538-7445.sabcs20-gs1-07
https://doi.org/10.1158/1538-7445.sabcs20-gs1-07
Autor:
Dhvanir Kansara, Eugen Dhimolea, Pallavi Awate, Alana L. Welm, Jordan Bryan, Brian J. Glassner, Zhiyi Liu, Shruti Sharma, Juliette Bouyssou, Rinath Jeselsohn, Aziz Al'Khafaji, Huihui Tang, Myles Brown, Nathanael S. Gray, Joseline Raja, Boris Bartholdy, Cihangir Duy, Aedín C. Culhane, Yu Chen, Xiang Weng, Ricardo De Matos Simoes, Jennifer Roth, Irene Georgakoudi, Dong Gao, Constantine S. Mitsiades, Ari Melnick, Ryosuke Shirasaki, Aviad Tsherniak, Francisca Vazquez, Michal Scheffer, Samantha Bender
Publikováno v:
Cancer Cell
Treatment-persistent residual tumors impede curative cancer therapy. To understand this cancer cell state we generate models of treatment persistence that simulate the residual tumors. We observe that treatment-persistent tumor cells in organoids, xe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27960f6b5655eb355223383013aae78c
https://europepmc.org/articles/PMC8670073/
https://europepmc.org/articles/PMC8670073/
Autor:
Caroline Vilas, Constantine S. Mitsiades, Dhvanir Kansara, Aziz Al'Khafaji, Juliette Bouyssou, Ricardo de Matos Simoes, Eugen Dhimolea, Aedin Culhane
Publikováno v:
Cancer Research. 81:42-42
Chemo-persistent residual tumors are a major barrier for curative cancer therapy and provide a reservoir of cancer cells for eventual relapse. This clinically critical tumor cell population is poorly understood and lacks faithful in vitro models. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8a77733f5074301a89b49ead5f7773c
https://doi.org/10.1158/1538-7445.am2021-42
https://doi.org/10.1158/1538-7445.am2021-42
Autor:
Constantine S. Mitsiades, Eugen Dhimolea, Dhvanir Kansara, Aviad Tsherniak, Jonathan D. Licht, Benjamin G. Barwick, Sondra L. Downey-Kopyscinski, Huihui Tang, Michal Sheffer, Ricardo De Matos Simoes, Shizuka Yamano, Megan Bariteau, Vikas Gupta, Sara Gandolfi, Jeffrey Sorrell, Lawrence H. Boise, Francisca Vazquez, Ryosuke Shirasaki, Aedín C. Culhane, Brian J. Glassner, Olga Dashevsky
Publikováno v:
Blood. 136:18-19
Background: Functional genomics studies based on CRISPR and shRNA have documented that multiple myeloma (MM) cells are preferentially dependent (compared to other neoplasias) on a series of TFs, including IKZF1 and IKZF3 (which are targeted by thalid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbd2fb200745abc04dd7b5de9141da70
https://doi.org/10.1182/blood-2020-142580
https://doi.org/10.1182/blood-2020-142580
Publikováno v:
Cancer Research. 78:5805-5805
Background: Upper Gastrointestinal Cancers (UGCs) respond poorly to conventional chemotherapy due to overactive intrinsic mechanisms that mediate cellular proliferation and drug resistance. Dysregulated cell division due to increased activity of cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016b66cc3b168f99caee4f6131d360ff
https://doi.org/10.1158/1538-7445.am2018-5805
https://doi.org/10.1158/1538-7445.am2018-5805
Autor:
Dhvanir Kansara, Tanvi Visal, Amruta Samant, Sonali Kurup, Priya Pancholi, Tanmay Dichwalkar, Vikas Sehdev, Robert Senones
Publikováno v:
Cancer Research. 78:2800-2800
Introduction: Upper Gastrointestinal Cancers (UGCs) exhibit resistance to conventional chemotherapy due to variable P53 status and constitutive overactivity of EGFR, ERBB2/HER-2, Aurora kinases, and JAK2 oncogenes. UGC is a leading cause of cancer re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca8038dd8d857058a0a08ce854c1f566
https://doi.org/10.1158/1538-7445.am2018-2800
https://doi.org/10.1158/1538-7445.am2018-2800
Autor:
Priya Pancholi, V. J. Rajadhyaksha, Tanvi Visal, Dhvanir Kansara, Amruta Samant, Shraddha Patel, Benjamin S. Hoffman, Vikas Sehdev, Manoj Maniar
Publikováno v:
Cancer Research. 77:2172-2172
Background: The overexpression of cyclin-dependent kinases 4/6 (CDK4/6) is known to cause cell cycle dysregulation in certain cancer types, making these cell cycle kinases attractive targets for pharmacological inhibition. The effectiveness of first-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a1d997c74f1da94a041042c9359520b
https://doi.org/10.1158/1538-7445.am2017-2172
https://doi.org/10.1158/1538-7445.am2017-2172
Autor:
Dhvanir Kansara, Amruta Samant, Tanvi Visal, Priya Pancholi, Sonali Kurup, Vikas Sehdev, Shraddha Patel, Samhita Bapat
Publikováno v:
Cancer Research. 77:4180-4180
Introduction: Upper Gastrointestinal Cancers (UGCs) are a leading cause of cancer-related mortality and account for approximately 1.1 million deaths worldwide. UGCs respond poorly to conventional chemotherapy due to constitutive over activity of mult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f878b447cd03e2529b6bf22df7d603e
https://doi.org/10.1158/1538-7445.am2017-4180
https://doi.org/10.1158/1538-7445.am2017-4180