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pro vyhledávání: '"Dhushy Thambipillai"'
Autor:
Nachum Kaplan, Vladimir Romanov, Pauls Henry W, Elias Bardouniotis, Teresa E. McGrath, Christine Picard, Dhushy Thambipillai, Andrew Leeson, Donald E. Awrey, Judd Berman, Peter Brent Sampson, Sean Handerson, Megan Domagala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5355-5358
Spiropiperidine naphthyridinone inhibitors of Staphylococcus aureus and Escherichia coli FabI have been prepared. Compounds 14a and 14c were identified as having sub-nanomolar E. coli FabI activity and are among the most potent FabI inhibitors yet de