Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Dhruva K. Mishra"'
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-9 (2018)
Abstract Background Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model’s lack of cellular components of the tum
Externí odkaz:
https://doaj.org/article/4b7cde03ebd04e92b36c45e2f5e06e94
Autor:
Mark J. Schliekelman, Chad J. Creighton, Brandi N. Baird, Yulong Chen, Priyam Banerjee, Neus Bota-Rabassedas, Young-Ho Ahn, Jonathon D. Roybal, Fengju Chen, Yiqun Zhang, Dhruva K. Mishra, Min P. Kim, Xin Liu, Barbara Mino, Pamela Villalobos, Jaime Rodriguez-Canales, Carmen Behrens, Ignacio I. Wistuba, Samir M. Hanash, Jonathan M. Kurie
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been full
Externí odkaz:
https://doaj.org/article/b98c31b4556442fb996362e7c46fd3c2
Autor:
David McCall, Eric R. Molina, Budi Utama, Danh Truong, Rafal Zielinski, Kristi Pence, Antonios G. Mikos, Salah Eddine Lamhamedi-Cherradi, Sandhya Krishnan, Brian A. Menegaz, Richard Gorlick, Joseph A. Ludwig, Dhruva K. Mishra, Sana Mohiuddin, Branko Cuglievan, Amelia M. Vetter, Najat C. Daw, Min P. Kim, Alejandra Ruiz Velasco, John A. Livingston
Publikováno v:
Cancer Gene Therapy
Osteosarcoma (OS) is a molecularly heterogeneous, aggressive, poorly differentiated pediatric bone cancer that frequently spreads to the lung. Relatively little is known about phenotypic and epigenetic changes that promote lung metastases. To identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0f86fbbe967be1d3476d6963ffd1cc
http://europepmc.org/articles/PMC8636268
http://europepmc.org/articles/PMC8636268
Autor:
Min P. Kim, Dhruva K. Mishra
Publikováno v:
Cancer Microenvironment
Activator protein (AP) -1 is a transcription factor, plays important role in cell differentiation, proliferation and apoptosis. Analysis of tumor cells grown on ex vivo 4D lung cancer model shows increase in components of AP-1, c-Fos and c-Jun in cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e10fa68db58a27dd49e68014d60c7c8
https://doi.org/10.1007/s12307-017-0202-0
https://doi.org/10.1007/s12307-017-0202-0
Autor:
Barbara Mino, Young Ho Ahn, Brandi N. Baird, Dhruva K. Mishra, Min P. Kim, Ignacio I. Wistuba, Chad J. Creighton, Carmen Behrens, Xin Liu, Yulong Chen, Jonathon D. Roybal, Priyam Banerjee, Neus Bota-Rabassedas, Fengju Chen, Samir M. Hanash, Pamela Villalobos, Yiqun Zhang, Mark J. Schliekelman, Jonathan M. Kurie, Jaime Rodriguez-Canales
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Cancer-associated fibroblasts (CAFs) regulate diverse intratumoral biological programs and can promote or inhibit tumorigenesis, but those CAF populations that negatively impact the clinical outcome of lung cancer patients have not been fully elucida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ad9c15567788b913ce1da3870b1665
https://doaj.org/article/b98c31b4556442fb996362e7c46fd3c2
https://doaj.org/article/b98c31b4556442fb996362e7c46fd3c2
Publikováno v:
Journal of Surgical Research. 210:181-187
Background Breast cancer mortality is most common in cancer in women, and there are no ex vivo models that can capture the primary growth of tumor with fidelity to the in vivo tumor growth. In this study, we grew human breast cancer cell lines in an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc04477cfeb5de1d420698ed818d040
https://doi.org/10.1016/j.jss.2016.11.019
https://doi.org/10.1016/j.jss.2016.11.019
Autor:
Gabriel Lopez-Berestein, Cristian Rodriguez-Aguayo, Prahlad T. Ram, Gordon B. Mills, Min P. Kim, Dhruva K. Mishra, Anil K. Sood, Rajesha Rupaimoole, Elena G. Seviour, Vasudha Sehgal, Jangsoon Lee
Publikováno v:
Oncogene
KRas is mutated in a significant number of human cancers and so there is an urgent therapeutic need to target KRas signalling. To target KRas in lung cancers we used a systems approach of integrating a genome-wide miRNA screen with patient-derived ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcfadc450ef0526ec0a3b0063ba6d94
https://doi.org/10.1038/onc.2016.308
https://doi.org/10.1038/onc.2016.308
Publikováno v:
Cancer Research. 80:5255-5255
Cancer is a genetic disease with increasing heterogeneity during disease progression. However, despite the widespread use of genomic testing, a recent publication estimated that only 5% of cancer patients in the US benefit from genome-driven targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7156e077e384280434c4872fa28f8340
https://doi.org/10.1158/1538-7445.am2020-5255
https://doi.org/10.1158/1538-7445.am2020-5255
Autor:
Amelia M. Vetter, Min P. Kim, Sandhya Krishnan, Danh Dinh Troung, Kristi Pence, Alejandra Ruiz Velasco, Sana Mohiuddin, Eric R. Molina, Joseph A. Ludwig, Salah-Eddine Lamhamedi-Cherradi, Dhruva K. Mishra, Brian A. Mnegaz, Branko Cuglievan
Publikováno v:
Cancer Research. 80:B44-B44
Objective: The main culprit for mortality in osteosarcoma (OS) is metastatic pulmonary disease, which originates from a highly selected group of tumor cells that acquire a heightened ability to migrate from the primary tumor, intravasate, and survive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcd23b7cb477661317ba47264651598c
https://doi.org/10.1158/1538-7445.pedca19-b44
https://doi.org/10.1158/1538-7445.pedca19-b44
A functional precision medicine 3D microtumor platform to identify and personalize novel indications
Publikováno v:
Journal of Clinical Oncology. 38:e15588-e15588
e15588 Background: We have previously validated our 3D microtumor platform that captures the tumor heterogeneity of a patient's primary tumor biopsy using a patient-derived xenograft model (Nikolov et al. ASCO 2019, e17076). Here we describe its util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8cbc660b31f9ddeeff746c597c600a2
https://doi.org/10.1200/jco.2020.38.15_suppl.e15588
https://doi.org/10.1200/jco.2020.38.15_suppl.e15588