Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Dhruva J. Dwivedi"'
Autor:
Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Introduction Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcom
Externí odkaz:
https://doaj.org/article/27fd2b1cf7f24f92a98ec9a101867c38
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Autor:
Erblin Cani, BSc, Dhruva J. Dwivedi, PhD, Kao-Lee Liaw, PhD, Douglas D. Fraser, MD, PhD, FRCPC, Calvin H. Yeh, MD, PhD, Claudio Martin, MSc, MD, FRCPC, Marat Slessarev, MD, PhD, FRCPC, Samantha E. Cerroni, BSc, Alison A. Fox-Robichaud, MSc, MD, FRCPC, Jeffrey I. Weitz, MD, FRCPS, Paul Y. Kim, PhD, Patricia C. Liaw, PhD, on behalf of the Canadian Critical Care Translational Biology Group (CCCTBG) and the COVID-BEACONS investigators
Publikováno v:
Critical Care Explorations, Vol 3, Iss 12, p e0588 (2021)
IMPORTANCE:. Coronavirus disease 2019 patients have an increased risk of thrombotic complications that may reflect immunothrombosis, a process characterized by blood clotting, endothelial dysfunction, and the release of neutrophil extracellular traps
Externí odkaz:
https://doaj.org/article/d13d089cf6e446818405457e8529a328
Autor:
Nicholas L. Jackson Chornenki, Robert Coke, Andrew C. Kwong, Dhruva J. Dwivedi, Michael K. Xu, Ellen McDonald, John C. Marshall, Alison E. Fox-Robichaud, Emmanuel Charbonney, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract Background Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and mechanism of release of cfDNA in trauma is not well understood. One potential s
Externí odkaz:
https://doaj.org/article/4ea7ab47ada3402ea7852e9c3d0b0cde
Autor:
Jaskirat Arora, MBBS, Jennifer A. Klowak, MD, MSc, FRCPC, Sameer Parpia, MSc, PhD, Marcelo Zapata-Canivilo, MD, Walaa Faidi, MSc, Christopher Skappak, MD, PhD, Rachael Gregoris, BHSc, Colin A. Kretz, BSc, PhD, Dhruva J. Dwivedi, BSc, MSc, PhD, Kerstin de Wit, BSc, MSc, MB ChB, MD, FRCPC, FRCEM, MRCP, Michelle Welsford, BSc, MD, FACEP, CCPE, FRCPC, Alison Fox-Robichaud, MSc, MD, FRCPC, on behalf of the Canadian Critical Care Translational Biology Group, Patricia Liaw, Jamie Hutchison, Jane Batt, Sean Gill, Jean-Francois Cailhier
Publikováno v:
Critical Care Explorations, Vol 3, Iss 4, p e0414 (2021)
Background:. Between 75% and 80% of patients with sepsis arrive in the hospital through the emergency department. Early diagnosis is important to alter patient prognosis, but currently, there is no reliable biomarker. The innate immune response links
Externí odkaz:
https://doaj.org/article/97e9fdeb85504be09052fd1bdf14f6b1
Autor:
Safiah H. C. Mai, Neha Sharma, Andrew C. Kwong, Dhruva J. Dwivedi, Momina Khan, Peter M. Grin, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Background Despite increasing ethical standards for conducting animal research, death is still often used as an endpoint in mouse sepsis studies. Recently, the Murine Sepsis Score (MSS), Mouse Clinical Assessment Score for Sepsis (M-CASS), a
Externí odkaz:
https://doaj.org/article/973867c602074b8e8820923b794da362
Autor:
Patricia C. Liaw, PhD, Alison E. Fox-Robichaud, MSc, MD, FRCPC, Kao-Lee Liaw, PhD, Ellen McDonald, RN, Dhruva J. Dwivedi, PhD, Nasim M. Zamir, MD, Laura Pepler, PhD, Travis J. Gould, PhD, Michael Xu, MSc, Nicole Zytaruk, RN, Sarah K. Medeiros, BSc, Lauralyn McIntyre, MD, FRCPC, Jennifer Tsang, MD, PhD, FRCPC, Peter M. Dodek, MD, MHSc, Brent W. Winston, MD, FRCPC, Claudio Martin, MSc, MD, FRCPC, Douglas D. Fraser, MD, PhD, FRCPC, Jeffrey I. Weitz, MD, FRCPC, Francois Lellouche, MD, PhD, Deborah J. Cook, MD, FRCPC, John Marshall, MD, FRCPC, for the Canadian Critical Care Translational Biology Group (CCCTBG) and the Canadian Critical Care Trials Group (CCCTG), Jamie Hutchison, Jane Batt, Emmanuel Charbonney, Jean-Francois Cailhier, Rob Fowler, Paul Hebert, Kusum Menon, Karen Burns, Shane English, John Drover, Bram Rochwerg, Dominique Piquette, Margaret Herridge, Sylvie Debigare, Srinivas Murthy, Michelle Kho, Danae Tassy
Publikováno v:
Critical Care Explorations, Vol 1, Iss 8, p e0032 (2019)
Objectives:. To determine if a set of time-varying biological indicators can be used to: 1) predict the sepsis mortality risk over time and 2) generate mortality risk profiles. Design:. Prospective observational study. Setting:. Nine Canadian ICUs. S
Externí odkaz:
https://doaj.org/article/322866702a8847a9bc12e98249ff2dbb
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:1485-1495
Extracellular histones exert cytotoxic and procoagulant effects which contribute to immunothrombosis in vascular diseases such as sepsis. Heparin has been shown to neutralize the pathologic effects of histones in vitro and in animal models.To compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ecbd215b8076d642c067726c8452acb
https://doi.org/10.1111/jth.15706
https://doi.org/10.1111/jth.15706
Autor:
Sreekant Damodara, Jaskirat Arora, Dhruva J. Dwivedi, Patricia C. Liaw, Alison E. Fox-Robichaud, P. Ravi Selvaganapathy, null Canadian Critical Care Translational Biology Group
Publikováno v:
Lab on a chip. 22(13)
Protein C is a vitamin K dependant protein in plasma that plays an essential role in regulating the coagulation cascade and inflammatory response. As a result of its importance in these roles, it has been suggested as a biomarker for prognosis of pat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7117a6f0c3fcf18858e8324f1e024b90
https://pubmed.ncbi.nlm.nih.gov/35678179
https://pubmed.ncbi.nlm.nih.gov/35678179
Publikováno v:
Shock. 56:975-987
Background Excessive production of neutrophil extracellular traps (NETs) in sepsis contributes to vascular occlusion by acting as a scaffold and stimulus for thrombus formation. Removal of extracellular DNA, the major structural component of NETs, by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbf4e0b653f4ba3ed66644703b8b40d
https://doi.org/10.1097/shk.0000000000001804
https://doi.org/10.1097/shk.0000000000001804