Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Dhruva Dhavale"'
Publikováno v:
Bulletin of the National Research Centre, Vol 47, Iss 1, Pp 1-16 (2023)
Abstract Background Amyloid beta peptide (Aβ) is the main component of plaques and is known to play a role in the development of Alzheimer's disease (AD). As a result, structures that can trap Aβ or disrupt the interaction between Aβ and cells hav
Externí odkaz:
https://doaj.org/article/8b61287f0e314751a44788d804b63fa5
Autor:
Jiang Zhu, Sara Pittman, Dhruva Dhavale, Rachel French, Jessica N. Patterson, Mohamed Salman Kaleelurrrahuman, Yuanzi Sun, Jaime Vaquer-Alicea, Gianna Maggiore, Christoph S. Clemen, William J. Buscher, Jan Bieschke, Paul Kotzbauer, Yuna Ayala, Marc I. Diamond, Albert A. Davis, Conrad Weihl
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-25 (2022)
Abstract Background Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), Tau, and TDP-43, contribute to neurodegeneration. The cellular machinery participating in this process is poorly understood. One proteinop
Externí odkaz:
https://doaj.org/article/47c9b932aac447af8c16f13a657d0a0e
Autor:
Chia-Ju Hsieh, Kuiying Xu, Iljung Lee, Thomas J. A. Graham, Zhude Tu, Dhruva Dhavale, Paul Kotzbauer, Robert H. Mach
Publikováno v:
ACS Omega, Vol 3, Iss 4, Pp 4486-4493 (2018)
Externí odkaz:
https://doaj.org/article/3f791d05b61544b8ad2bcf5486bb3eb7
Publikováno v:
Molecular immunology. 154
Parkinson's disease (PD) is a neurodegenerative disorder characterized by chronic neuroinflammation, loss of dopaminergic neurons in the substantia nigra, and in several cases accumulation of alpha-synuclein fibril (α-syn) containing Lewy-bodies (LB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a40ffd922dec020e02c3da7da8bca2b
https://pubmed.ncbi.nlm.nih.gov/36571978
https://pubmed.ncbi.nlm.nih.gov/36571978
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84614b13f5b4d8b685e137025421db8a
https://doi.org/10.1096/fasebj.2022.36.s1.r4474
https://doi.org/10.1096/fasebj.2022.36.s1.r4474
Autor:
Jessica N. Patterson, Sara K. Pittman, Yuna M. Ayala, Jan Bieschke, Paul T. Kotzbauer, Mohamed Salman Kaleelurrrahuman, William J. Buscher, Dhruva Dhavale, Conrad C. Weihl, Yuanzi Sun, Albert A. Davis, Jiang Zhu, Rachel L. French
Background: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), tau, and TDP-43, contribute to neurodegeneration and disease progression. The cellular machinery necessary for this process is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2c9ab2ae6c2ddebc252e0e57da8e8
https://doi.org/10.1101/2021.07.12.452081
https://doi.org/10.1101/2021.07.12.452081
Autor:
Jennifer L. Furman, Eun Suk Song, Tritia R. Yamasaki, Marc I. Diamond, Bryant W. Su, Dhruva Dhavale, Paul T. Kotzbauer, Brandon B. Holmes, Nigel J. Cairns
Publikováno v:
The Journal of Biological Chemistry
Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in neurons and glial cells. These disorders and other neurodegenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96043ca139c7e5b79ef98ca37071ebf
https://doi.org/10.1074/jbc.ra118.004471
https://doi.org/10.1074/jbc.ra118.004471
Autor:
Paul T. Kotzbauer, Umber Dube, Jason D. Ulrich, Patrick Sullivan, Brittany M. Freeberg, Alexander Galluppi, Carlos Cruchaga, Jessica N. Haines, Joel S. Perlmutter, David M. Holtzman, Rebecca L. Miller, Bruno A. Benitez, Casey E. Inman, Dhruva Dhavale, Fahim A. Choudhury, Zachary M. Wargel, Albert A. Davis
Publikováno v:
Science Translational Medicine. 12
Apolipoprotein E (APOE) e4 genotype is associated with increased risk of dementia in Parkinson's disease (PD), but the mechanism is not clear, because patients often have a mixture of α-synuclein (αSyn), amyloid-β (Aβ), and tau pathologies. APOE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcb98539a80a5bb7fef8aaf813a8b30d
https://doi.org/10.1126/scitranslmed.aay3069
https://doi.org/10.1126/scitranslmed.aay3069
Autor:
Kuiying Xu, Thomas J. A. Graham, Paul T. Kotzbauer, Iljung Lee, Zhude Tu, Robert H. Mach, Chia-Ju Hsieh, E. James Petersson, John J. Ferrie, Jennifer Yu, Dhruva Dhavale
Publikováno v:
ACS Chemical Neuroscience. 9:2521-2527
The fibrillary aggregation of the protein alpha synuclein (Asyn) is a hallmark of Parkinson’s disease, and the identification of small molecule binding sites on fibrils is essential to the development of diagnostic imaging probes. A series of molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c7e8660ba38de7a46c5053b80d2f47
https://doi.org/10.1021/acschemneuro.8b00177
https://doi.org/10.1021/acschemneuro.8b00177
Autor:
Paul T. Kotzbauer, Zonghua Luo, Zhude Tu, Jialu Liu, Dhruva Dhavale, Hao Yang, Robert H. Mach, Xuyi Yue, Junfeng Li
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:1011-1019
Here we report the synthesis and in vitro evaluation of 25 new quinolinyl analogues for α-synuclein aggregates. Three lead compounds were subsequently labeled with carbon-11 or fluorine-18 to directly assess their potency in a direct radioactive com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca6b25522c58b6a27392aabfbe83b653
https://doi.org/10.1016/j.bmcl.2018.02.031
https://doi.org/10.1016/j.bmcl.2018.02.031