Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dhruva Deshpande"'
Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model
Autor:
Florian Olde Heuvel, Najwa Ouali Alami, Oumayma Aousji, Esther Pogatzki-Zahn, Peter K. Zahn, Hanna Wilhelm, Dhruva Deshpande, Elmira Khatamsaz, Alberto Catanese, Sarah Woelfle, Michael Schön, Sanjay Jain, Stefanie Grabrucker, Albert C. Ludolph, Chiara Verpelli, Jens Michaelis, Tobias M. Boeckers, Francesco Roselli
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract Background Autism Spectrum Disorders (ASD) patients experience disturbed nociception in the form of either hyposensitivity to pain or allodynia. A substantial amount of processing of somatosensory and nociceptive stimulus takes place in the
Externí odkaz:
https://doaj.org/article/bde43bf68ebe4d2c8f5a05d540104911
Autor:
Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Heiko Braak, Kelly Del Tredici, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers, Michael Schön
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-28 (2023)
Abstract Background Post mortem human brain tissue is an essential resource to study cell types, connectivity as well as subcellular structures down to the molecular setup of the central nervous system especially with respect to the plethora of brain
Externí odkaz:
https://doaj.org/article/2fa2b3278a9241a7b0218406d99828a4
Autor:
Dhruva Deshpande, Julia Higelin, Michael Schoen, Thomas Vomhof, Tobias M. Boeckers, Maria Demestre, Jens Michaelis
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mutations in the fused in Sarcoma (FUS) gene induce cytoplasmic FUS aggregations, contributing to the neurodegenerative disease amyotrophic lateral sclerosis (ALS) in certain cases. While FUS is mainly a nuclear protein involved in transcriptional pr
Externí odkaz:
https://doaj.org/article/fd25c1dffa5e4e0383d41d63d081d057
Autor:
Dhruva Deshpande, Mark Grieshober, Fanny Wondany, Fabian Gerbl, Reiner Noschka, Jens Michaelis, Steffen Stenger
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6741 (2020)
The antimicrobial peptide LL-37 inhibits the growth of the major human pathogen Mycobacterium tuberculosis (Mtb), but the mechanism of the peptide–pathogen interaction inside human macrophages remains unclear. Super-resolution imaging techniques pr
Externí odkaz:
https://doaj.org/article/b380ab3edd0147e4839e1d51a7f5f738
Autor:
Sarah Woelfle, Dhruva Deshpande, Simone Feldengut, Francesco Roselli, Karl Deisseroth, Jens Michaelis, Tobias M. Boeckers, Michael Schön
Immunohistochemistry on archival human brains is often limited because several conditions arise that complicate the use for high-resolution fluorescence microscopy. In this study, we developed a novel clearing approach for immunofluorescence-based an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6900f084b17ee6b4409833f2c35a23a1
https://doi.org/10.1101/2022.04.27.489700
https://doi.org/10.1101/2022.04.27.489700
Autor:
Fabian Gerbl, Jens Michaelis, Dhruva Deshpande, Mark Grieshober, Steffen Stenger, Fanny Wondany, Reiner Noschka
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6741, p 6741 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 18
International Journal of Molecular Sciences
Volume 21
Issue 18
The antimicrobial peptide LL-37 inhibits the growth of the major human pathogen Mycobacterium tuberculosis (Mtb), but the mechanism of the peptide&ndash
pathogen interaction inside human macrophages remains unclear. Super-resolution imaging tech
pathogen interaction inside human macrophages remains unclear. Super-resolution imaging tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d328b0003e9a4fd52163f93b19e425b
https://www.mdpi.com/1422-0067/21/18/6741
https://www.mdpi.com/1422-0067/21/18/6741
Autor:
Dhruva, Deshpande, Julia, Higelin, Michael, Schoen, Thomas, Vomhof, Tobias M, Boeckers, Maria, Demestre, Jens, Michaelis
Publikováno v:
Frontiers in cellular neuroscience 13, 256 (2019). doi:10.3389/fncel.2019.00256
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Mutations in the fused in Sarcoma (FUS) gene induce cytoplasmic FUS aggregations, contributing to the neurodegenerative disease amyotrophic lateral sclerosis (ALS) in certain cases. While FUS is mainly a nuclear protein involved in transcriptional pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::251327fa6f90515519aa0f71cbd5f9e3
https://pub.dzne.de/record/140755
https://pub.dzne.de/record/140755
Autor:
Karin M Danzer, Karlheinz Holzmann, Susanne Petri, Jens Michaelis, Markus Otto, Sarah J Brockmann, Jochen H. Weishaupt, Axel Freischmidt, Albert C. Ludolph, David A. Brenner, Peter M. Andersen, Dietmar Rudolf Thal, Joerg Reinders, Steffen Just, Anika M. Helferich, Dhruva Deshpande
Publikováno v:
Cellular and molecular life sciences : CMLS. 75(23)
Genetic and functional studies suggest diverse pathways being affected in the neurodegenerative disease amyotrophic lateral sclerosis (ALS), while knowledge about converging disease mechanisms is rare. We detected a downregulation of microRNA-1825 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c5eebb27dd28c0abdb9fb1433fe2dc
https://pubmed.ncbi.nlm.nih.gov/30030593
https://pubmed.ncbi.nlm.nih.gov/30030593
Autor:
Rudolf Merkel, Benjamin Wolters, Tripti Gautam, Anna Csiszar, Bernd Hoffmann, Dhruva Deshpande, Zoltan Ungvari, Nils Hersch, Agnes Csiszár
Publikováno v:
Journal of Biomaterials Applications. 30:846-856
Purification of defined cell populations from mixed primary cell sources is essential for many biomedical and biotechnological applications but often very difficult to accomplish due to missing specific surface markers. In this study, we developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c69d852fe32f3a48ca2f4eb38962ad2f
https://doi.org/10.1177/0885328215603026
https://doi.org/10.1177/0885328215603026
Autor:
Maria Demestre, Jens Michaelis, Stefan Putz, Albert C. Ludolph, Stefan Liebau, Michael J. Schmeisser, Christian Proepper, Tobias M. Boeckers, Michael Schoen, Dhruva Deshpande, Jochen M. Reichel
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 9 (2016)
Frontiers in Cellular Neuroscience
Frontiers in Cellular Neuroscience
Fused in Sarcoma (FUS) is a multifunctional RNA- / DNA-binding protein, which is involved in the pathogenesis of the neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). A common hallmark of these disorde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b85acb714b51dee15cf7d931fe2bf8