Výsledky vyhledávání - "Dhruv N. Patel"

Akademický článek

Chemical Complementarity of Breast Cancer Resident, T-Cell Receptor CDR3 Domains and the Cancer Antigen, ARMC3, is Associated With Higher Levels of Survival and Granzyme Expression

Autor: Nagehan Pakasticali, Andrea Chobrutskiy, Dhruv N. Patel, Monica Hsiang, Saif Zaman, Konrad J. Cios, George Blanck, Boris I. Chobrutskiy

Publikováno v: Cancer Informatics, Vol 22 (2023)

Introduction: One of the most pressing goals for cancer immunotherapy at this time is the identification of actionable antigens. Methods: This study relies on the following considerations and approaches to identify potential breast cancer antigens: (

Externí odkaz: https://doaj.org/article/e21da741804642b483c70329929599a7

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Chemical complementarity between tumor resident, T-cell receptor CDR3s and MAGEA3/6 correlates with increased melanoma survival: Potential relevance to MAGE vaccine auto-reactivity

Autor: Rachel A. Eakins, Andrea Chobrutskiy, Jamie K. Teer, Dhruv N. Patel, Monica Hsiang, Taha I. Huda, Saif Zaman, Wade J. Sexton, Domenico Coppola, Shayan Falasiri, George Blanck, Boris I. Chobrutskiy

Publikováno v: Molecular Immunology. 150:58-66

Cancer testis antigens have been of interest as possible targets for cancer immunotherapies. To better understand the opportunities for the use of such immunotherapy targets, we used a chemical complementarity scoring algorithm and an original web to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2dafbe5862d88e8a643f8f309d4620
https://doi.org/10.1016/j.molimm.2022.08.001

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A study on the damage tolerance of durable redundant composite sandwich joints

Autor: Vinay K Goyal, Eric C Lundgren, Dhruv N Patel

Publikováno v: Journal of Sandwich Structures & Materials. 25:164-179

A patented Durable Redundant Joint (DRJ) concept featuring multiple adhesive load-paths, via a novel composite preform insert, is being considered for joining composite sandwich panel segments. Applications are wide ranging from spacecraft bus struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb4b7883b24a1db1620eab6bbfd842bc
https://doi.org/10.1177/10996362221130968

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Strength of asymmetric tapered composite foam core sandwich structures subjected to thermomechanical loading

Autor: Vinay Goyal, Jacob I Rome, Dhruv N Patel

Publikováno v: Journal of Sandwich Structures & Materials. 25:6-22

An experimental test program and companion analytical study were designed and conducted to gain understanding of the tensile failure mechanisms in asymmetrical tapered sandwich core structures at cold temperatures. Representative test coupons were su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c34acae80df53ceb5e03ee4b64d8e9
https://doi.org/10.1177/10996362221106782

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A Bioinformatics Assessment Indicating Better Outcomes With Breast Cancer Resident, Immunoglobulin CDR3-MMP2 Binding

Autor: SUHAAS R. MANDALA, ALEXIS J. THOMSON, ETIENNE C. GOZLAN, DHRUV N. PATEL, ANDREA CHOBRUTSKIY, BORIS I. CHOBRUTSKIY, GEORGE BLANCK

Publikováno v: Cancer Genomics Proteomics

Background/Aim: The recombination of V, D, and J immunoglobulin (IG) gene segments leads to many variations in the amino acids (AAs) encoded at that site, the complementarity determining region-3 (CDR3). Thus, cancer patients may have varying degrees

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d975c140720acc26d2bbcb3a770935
https://europepmc.org/articles/PMC10148069/

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Chemical complementarity between immune receptor CDR3s and candidate cancer antigens correlating with reduced survival: evidence for outcome mitigation with corticosteroid treatments

Autor: Anishaa R. Patel, Dhruv N. Patel, Yaping N. Tu, Michelle Yeagley, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck

Publikováno v: Journal of Biomolecular Structure and Dynamics. :1-9

The evaluation of physicochemical characteristics of extensive adaptive immune receptor (IR) recombination sequence collections has led to the discovery of many correlations of those sequences and a variety of diseases, including cancer. In the cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c31b3183f26fe488c5310aa503888a
https://doi.org/10.1080/07391102.2022.2070546

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TCR CDR3‐antigen chemical complementarity associated with poor ovarian cancer outcomes: A vestigial immune response to early cancer antigens?

Autor: Vayda R. Barker, Mallika Varkhedi, Dhruv N. Patel, Monica Hsiang, Andrea Chobrutskiy, Boris I. Chobrutskiy, George Blanck

Publikováno v: American Journal of Reproductive Immunology. 89

Ovarian cancer continues to present significant challenges for early detection and treatment, indicating a need for novel approaches to improve disease outcomes. In this report, we applied a previously described algorithm for detecting chemical compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926153847e1c0956782ead4d28d6fc60
https://doi.org/10.1111/aji.13639

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