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Akademický článek

TNF-α differentially modulates subunit levels of respiratory electron transport complexes of ER/PR +ve/−ve breast cancer cells to regulate mitochondrial complex activity and tumorigenic potential

Autor: Anjali Shinde, Hyeryeon Jung, Hayun Lee, Kritarth Singh, Milton Roy, Dhruv Gohel, Han Byeol Kim, Minal Mane, Hitesh Vasiyani, Fatema Currim, Yu Ri Seo, Seojin Yang, Ara Cho, Eugene C. Yi, Rajesh Singh

Publikováno v: Cancer & Metabolism, Vol 9, Iss 1, Pp 1-15 (2021)

Abstract Background Tumor necrosis factor-α (TNF-α) is an immunostimulatory cytokine that is consistently high in the breast tumor microenvironment (TME); however, its differential role in mitochondrial functions and cell survival in ER/PR +ve and

Externí odkaz: https://doaj.org/article/97b7af9f07ec4e83857bc19075a6d5ef

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DNA damage induces STING mediated IL-6-STAT3 survival pathway in triple-negative breast cancer cells and decreased survival of breast cancer patients

Autor: Hitesh Vasiyani, Minal Mane, Khushboo Rana, Anjali Shinde, Milton Roy, Jyoti Singh, Dhruv Gohel, Fatema Currim, Ratika Srivastava, Rajesh Singh

Publikováno v: Apoptosis : an international journal on programmed cell death. 27(11-12)

Triple-negative breast cancer is aggressive and metastatic breast cancer type and shows immune evasion, drug resistance, relapse and poor survival. Anti-cancer therapy like ionizing radiation and chemotherapeutic drug majorly induces DNA damage hence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e45e2d951890402532353bb364181c
https://pubmed.ncbi.nlm.nih.gov/36018392

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The analog of cGAMP, c-di-AMP, activates STING mediated cell death pathway in estrogen-receptor negative breast cancer cells

Autor: Minal Mane, Hitesh Vasiyani, Rajesh Singh, Kritarth Singh, Jyoti Singh, Fatema Currim, Anjali Shinde, Milton Roy, Dhruv Gohel, Mahesh Chhabria, Khushali Vaidya

Publikováno v: Apoptosis. 26:293-306

Immune adaptor protein like STING/MITA regulate innate immune response and plays a critical role in inflammation in the tumor microenvironment and regulation of metastasis including breast cancer. Chromosomal instability in highly metastatic cells re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2075cda799751bcf22ce85154816af3
https://doi.org/10.1007/s10495-021-01669-x

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Different platforms for mitomiRs in mitochondria: Emerging facets in regulation of mitochondrial functions

Autor: Dhruv Gohel, Rajesh Singh

Publikováno v: Mitochondrion. 66

Mitochondria are one of the central organelles involved in cellular energy metabolism and play a regulatory role in various human pathologies ranging from inborn errors of metabolism, cancer, inflammation, and infections. Mitochondrial DNA encodes li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e866601c668cf976c9eaf62c12198e
https://pubmed.ncbi.nlm.nih.gov/35944834

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Enforced lysosomal biogenesis rescues erythromycin- and clindamycin-induced mitochondria-mediated cell death in human cells

Autor: Bhavana Joshi, Pooja Dalwadi, Joe E. Springer, Milton Roy, Dhruv Gohel, Rajesh Singh, Khyati Bhatelia, Kritarth Singh, Lakshmi Sripada, Wang-Xia Wang, Paresh Prajapati, Rochika Singh

Publikováno v: Molecular and Cellular Biochemistry. 461:23-36

Antibiotics are the front-line treatment against many bacterial infectious diseases in human. The excessive and long-term use of antibiotics in human cause several side effects. It is important to understand the underlying molecular mechanisms of act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1575d06b2b811ca06197879087bead5
https://doi.org/10.1007/s11010-019-03585-w

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FMRpolyG alters mitochondrial transcripts level and respiratory chain complex assembly in Fragile X associated tremor/ataxia syndrome [FXTAS]

Autor: Milton Roy, Dhruv Gohel, Nicolas Charlet-Berguerand, Kritarth Singh, Lakshmi Sripada, Rajesh Singh, Darshan Kotadia, Flora Tassone, Paresh Prajapati

Publikováno v: Biochimica et Biophysica Acta-Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, Elsevier, 2019, 1865 (6), pp.1379-1388. ⟨10.1016/j.bbadis.2019.02.010⟩

Fragile X-associated tremor/ataxia syndrome (FXTAS) is an inherited neurodegenerative disorder caused by an expansion of 55 to 200 CGG repeats (premutation) in FMR1. These CGG repeats are Repeat Associated non-ATG (RAN) translated into a small and pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b8384c654cb58b4da5af3b51fec5c7
https://doi.org/10.1016/j.bbadis.2019.02.010

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