Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Dhoonmoon A"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Replication stress compromises genomic integrity. Fork blocking lesions such as those induced by cisplatin and other chemotherapeutic agents arrest replication forks. Repriming downstream of these lesions represents an important mechanism of
Externí odkaz:
https://doaj.org/article/91581a74d5184f80833b47a45c7b283a
Autor:
Keith Wilson, Janet Bouttell, Judith Tanner, Roy Harris, Jacqueline Beckhelling, Melissa Rochon, James Jurkiewicz, Lara Mason, Sarah Bolton, Jon Dummer, Luxmi Dhoonmoon, Karen Cariaga
Publikováno v:
BMJ Open, Vol 14, Iss 9 (2024)
Introduction Digital surgical wound monitoring for patients at home is becoming an increasingly common method of wound follow-up. This regular monitoring improves patient outcomes by detecting wound complications early and enabling treatment to start
Externí odkaz:
https://doaj.org/article/978a7dff55ea421fa93284209445d5a2
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Accumulation of single stranded DNA (ssDNA) gaps in the nascent strand during DNA replication has been associated with cytotoxicity and hypersensitivity to genotoxic stress, particularly upon inactivation of the BRCA tumor suppressor pathway
Externí odkaz:
https://doaj.org/article/fd6a77a2b70d4ad48b428ac71575a32e
Autor:
A. J. Dubnick, R. L. Spietz, B. D. Danielson, M. L. Skidmore, E. S. Boyd, D. Burgess, C. Dhoonmoon, M. Sharp
Publikováno v:
The Cryosphere, Vol 17, Pp 2993-3012 (2023)
Subglacial environments comprise ∼10 % of Earth's land surface, host active microbial ecosystems, and are important components of global biogeochemical cycles. However, the broadly inaccessible nature of subglacial systems has left them vastly unde
Externí odkaz:
https://doaj.org/article/a37e2d4aeee14b8a87c0c619158dc1c7
Akademický článek
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Autor:
Tanay Thakar, Ashna Dhoonmoon, Joshua Straka, Emily M. Schleicher, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Efficient DNA replication is crucial for genome stability. Here, Thakar et al. report that accumulation of lagging strand ssDNA gaps during replication interferes with nucleosome assembly and drives replication fork degradation in BRCA-deficient cell
Externí odkaz:
https://doaj.org/article/2dd4e50ca1d340f4ae9cf8bf31f43a9d
Akademický článek
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Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Protection of replication forks against nucleolytic degradation is crucial for genome stability. Here, Dhoonmoon et al identify PARP14 and the KU complex as essential regulators of fork degradation by MRE11 and EXO1 nucleases in BRCA-deficient cells.
Externí odkaz:
https://doaj.org/article/fcffd21913bc45bdb2ca47c3e609a412
Autor:
Emily M. Schleicher, Ashna Dhoonmoon, Lindsey M. Jackson, Jude B. Khatib, Claudia M. Nicolae, George-Lucian Moldovan
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA pathway, are subsequently subje
Externí odkaz:
https://doaj.org/article/62ab80586c0647d183275c406a41f42c
Autor:
Iwona Hirschler-Laszkiewicz, Fernanda Festa, Suming Huang, George-Lucian Moldovan, Claudia Nicolae, Ashna Dhoonmoon, Lei Bao, Kerry Keefer, Shu-jen Chen, Hong-Gang Wang, Joseph Y. Cheung, Barbara A. Miller
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant response. Here, the role of TRPM2 in
Externí odkaz:
https://doaj.org/article/4fbf757ed7af457bbd255a2db843529c