Early Disruption of Photoreceptor Cell Architecture and Loss of Vision in a Humanized Pig Model of Usher Syndrome

Autor: Suchankova S, Andreas Blutke, E. Wolf, Joshua Linnert, Fischer, Grotz S, Döring A, Uwe Wolfrum, Jessica Schäfer, Fischer A, May-Simera H, Nikolai Klymiuk, Zakharchenko, Jan Motlik, Runa-Vochozkova P, Andrea Bähr, Vandenberghe Lh, K L Laugwitz, Plutniok J, Kerstin Nagel-Wolfrum, T. Ardan, Gianluca Santamaria, Kirsten A. Wunderlich, Barbara Kessler, Mayuko Kurome, Auch H, Dhom G, Arnold, Zdenka Ellederova, Veith M, Popelar J, Wolfgang Hitzl

Usher syndrome (USH) is the most common form of monogenic deaf-blindness. Loss of vision is untreatable and, so far, there are no suitable animal models for testing therapeutic strategies. By introducing a human mutation into the harmonin-encoding US

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b39774ffb8a3b79bca9ea6385213fecd
https://doi.org/10.1101/2021.05.31.446123

Early disruption of photoreceptor cell architecture and loss of vision in a humanized pig model of usher syndromes.

Autor: Grotz S; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Schäfer J; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Wunderlich KA; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Ellederova Z; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic., Auch H; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Bähr A; Center for Innovative Medical Models, LMU Munich, Munich, Germany.; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany., Runa-Vochozkova P; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany., Fadl J; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Arnold V; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Ardan T; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic., Veith M; Ophthalmology Clinic, University Hospital Kralovske Vinohrady, Praha, Czech Republic., Santamaria G; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany., Dhom G; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Hitzl W; Biostatistics and Data Science, Paracelsus Medical University, Salzburg, Austria., Kessler B; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Eckardt C; Center for Innovative Medical Models, LMU Munich, Munich, Germany.; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany., Klein J; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Brymova A; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic., Linnert J; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Kurome M; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Zakharchenko V; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Fischer A; Veterinary Faculty, Small Animal Clinics, LMU Munich, Munich, Germany., Blutke A; Institute of Experimental Genetics, Helmholtz Center Munich, Neuherberg, Germany., Döring A; Veterinary Faculty, Small Animal Clinics, LMU Munich, Munich, Germany., Suchankova S; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic., Popelar J; Institute of Experimental Medicine, Czech Academy of Science, Prague, Czech Republic., Rodríguez-Bocanegra E; Centre for Ophthalmology, University Eye Hospital, University Hospital Tübingen, Tübingen, Germany.; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Dlugaiczyk J; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Zurich (USZ), University of Zurich, Zurich, Switzerland., Straka H; Faculty of Biology, LMU Munich, Planegg, Germany., May-Simera H; Institute of Molecular Physiology, Cilia Biology, JGU Mainz, Mainz, Germany., Wang W; Grousbeck Gene Therapy Center, Mass Eye and Ear and Harvard Medical School, Boston, MA, USA., Laugwitz KL; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany., Vandenberghe LH; Grousbeck Gene Therapy Center, Mass Eye and Ear and Harvard Medical School, Boston, MA, USA., Wolf E; Chair of Molecular Animal Breeding and Biotechnology, LMU Munich, Munich, Germany.; Center for Innovative Medical Models, LMU Munich, Munich, Germany., Nagel-Wolfrum K; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany.; Institute of Developmental Biology and Neurobiology, Johannes Gutenberg University (JGU), Mainz, Germany., Peters T; Centre for Ophthalmology, University Eye Hospital, University Hospital Tübingen, Tübingen, Germany.; Institute for Ophthalmic Research, Centre for Ophthalmology, University Hospital Tübingen, Tübingen, Germany., Motlik J; Institute of Animal Physiology and Genetics, Czech Academy of Science, Libechov, Czech Republic., Fischer MD; Oxford Eye Hospital, Oxford University NHS Foundation Trust, Oxford, UK.; Nuffield Laboratory of Ophthalmology, NDCN, University of Oxford, Oxford, UK., Wolfrum U; Institute of Molecular Physiology, Molecular Cell Biology, Johannes Gutenberg University (JGU), Mainz, Germany., Klymiuk N; Center for Innovative Medical Models, LMU Munich, Munich, Germany.; Large Animal Models in Cardiovascular Research, Internal Medical Department I, TU Munich, Munich, Germany.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2022 Apr 07; Vol. 14 (4), pp. e14817. Date of Electronic Publication: 2022 Mar 07.

Optical Efficacy of Titanium Nitride-Coated Abutment Material on Soft Tissue Discoloration: A Spectrophotometric In Vitro Analysis.

Autor: Gehrke P, Zimmermann KP, Weinhold O, Dhom G, Fischer C, Sader R

Publikováno v: The International journal of oral & maxillofacial implants [Int J Oral Maxillofac Implants] 2021 Jul-Aug; Vol. 36 (4), pp. e91-e96.

Unbiased analysis of obesity related, fat depot specific changes of adipocyte volumes and numbers using light sheet fluorescence microscopy.

Autor: Theobalt N; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Hofmann I; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Fiedler S; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Renner S; Gene Center and Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Veterinary Sciences, Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Dhom G; Gene Center and Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Veterinary Sciences, Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleißheim, Germany., Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany., Hrabĕ de Angelis M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany., Wolf E; Gene Center and Department of Veterinary Sciences, Chair for Molecular Animal Breeding and Biotechnology, Ludwig-Maximilians-Universität München, Munich, Germany.; Department of Veterinary Sciences, Center for Innovative Medical Models (CiMM), Ludwig-Maximilians-Universität München, Oberschleißheim, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Laboratory for Functional Genome Analysis (LAFUGA), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany., Wanke R; Institute of Veterinary Pathology at the Center for Clinical Veterinary Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Blutke A; Research Unit Analytical Pathology, Helmholtz Zentrum München, Neuherberg, Germany.

Publikováno v: PloS one [PLoS One] 2021 Mar 16; Vol. 16 (3), pp. e0248594. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2021).

100 Jahre Deutsche Gesellschaft für Pathologie (1897–1997) (One hundred years of the Germany Society of Pathology (1897–1997))

Autor: Dhom G

Publikováno v: Der Pathologe. 18:S1-S17

The German Society of Pathology emerged from the Society of German Scientists and Physicians. Founded in Braunschweig in 1897, the first scientific meeting was held in Dusseldorf in 1898. Rudolf Virchow was the first chairman up to this death in 1902

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::942d41573ac53e38b91d18cfeb7fa43c
https://doi.org/10.1007/s002920050401