Výsledky vyhledávání - "Dhivya Shanmugarajan"

Akademický článek

Gas chromatography-mass spectrometry metabolic profiling, molecular simulation and dynamics of diverse phytochemicals of Punica granatum L. leaves against estrogen receptor

Autor: Talambedu Usha, Sushil Kumar Middha, Dhivya Shanmugarajan, Dinesh Babu, Arvind Kumar Goyal, Hasan Soliman Yusufoglu, Kora Rudraiah Sidhalinghamurthy

Publikováno v: Frontiers in Bioscience-Landmark, Vol 26, Iss 9, Pp 423-441 (2021)

Introduction: Breast cancer is the most common type of cancer globallyand its treatment with many FDA-approved synthetic drugs manifests various sideeffects. Alternatively, phytochemicals are natural reserves of novel drugsfor cancer therapy. Punica

Externí odkaz: https://doaj.org/article/9ab145ce03d748e098fe6a05ce98c94c

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Akademický článek

Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity

Autor: Saleem Javid, Hissana Ather, Umme Hani, Ayesha Siddiqua, Shaik Mohammad Asif Ansari, Dhivya Shanmugarajan, Honnavalli Yogish Kumar, Rajaguru Arivuselvam, Madhusudan N. Purohit, B. R. Prashantha Kumar

Publikováno v: Antibiotics, Vol 12, Iss 7, p 1167 (2023)

In recent years, N-Myristoyltransferase (NMT) has been identified as a new target for the treatment of fungal infections. It is observed that at present, there are increased rates of morbidity and mortality due to fungal infections. Hence, a series o

Externí odkaz: https://doaj.org/article/f7af085dacb648399e0dd23b4ca6493b

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Akademický článek

Novel Derivatives of Eugenol as a New Class of PPARγ Agonists in Treating Inflammation: Design, Synthesis, SAR Analysis and In Vitro Anti-Inflammatory Activity

Autor: Noor Fathima Anjum, Dhivya Shanmugarajan, B. R. Prashantha Kumar, Syed Faizan, Priya Durai, Ruby Mariam Raju, Saleem Javid, Madhusudan N. Purohit

Publikováno v: Molecules, Vol 28, Iss 9, p 3899 (2023)

The main objective of this research was to develop novel compounds from readily accessed natural products especially eugenol with potential biological activity. Eugenol, the principal chemical constituent of clove (Eugenia caryophyllata) from the fam

Externí odkaz: https://doaj.org/article/20b51c7c9171415caf68c0380042a41d

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Akademický článek

Virtual Screening for Identification of Dual Inhibitors against CDK4/6 and Aromatase Enzyme

Autor: Tenzin Adon, Dhivya Shanmugarajan, Hissana Ather, Shaik Mohammad Asif Ansari, Umme Hani, SubbaRao V. Madhunapantula, Yogish Kumar Honnavalli

Publikováno v: Molecules, Vol 28, Iss 6, p 2490 (2023)

CDK4/6 and aromatase are prominent targets for breast cancer drug discovery and are involved in abnormal cell proliferation and growth. Although aromatase inhibitors have proven to be effective (for example exemestane, anastrozole, letrozole), resist

Externí odkaz: https://doaj.org/article/c83ed7dc846a4d0c8ba4c14dbc0e36cb

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Discovery of Novel Myristic Acid Derivatives as N-Myristoyltransferase Inhibitors: Design, Synthesis, Analysis, Computational Studies and Antifungal Activity

Autor: Kumar, Saleem Javid, Hissana Ather, Umme Hani, Ayesha Siddiqua, Shaik Mohammad Asif Ansari, Dhivya Shanmugarajan, Honnavalli Yogish Kumar, Rajaguru Arivuselvam, Madhusudan N. Purohit, B. R. Prashantha

Publikováno v: Antibiotics; Volume 12; Issue 7; Pages: 1167

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::2b98138ca53f0fd79d08b357e4a03e78

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Estrogen receptor potentially stable conformations from molecular dynamics as a structure-based pharmacophore model for mapping, screening, and identifying ligands-a new paradigm shift in pharmacophore screening

Autor: Dhivya Shanmugarajan, Charles David

Publikováno v: Journal of biomolecular structuredynamics.

Despite rigorous research on breast cancer has increased in recent decades, only few drugs are in practice to combat against the disease. Due to excessive usage, these drugs attain resistance is an avertable phenomenon resulting from inadequate treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb7980c9a77b7aac81e72ffccecad6e
https://pubmed.ncbi.nlm.nih.gov/35543232

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