Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Dhivya, Sridaran"'
Autor:
Surbhi Chouhan, Dhivya Sridaran, Cody Weimholt, Jingqin Luo, Tiandao Li, Myles C. Hodgson, Luana N. Santos, Samantha Le Sommer, Bin Fang, John M. Koomen, Markus Seeliger, Cheng-Kui Qu, Armelle Yart, Maria I. Kontaridis, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Mutations that decrease or increase the activity of the tyrosine phosphatase, SHP2 (encoded by PTPN11), promotes developmental disorders and several malignancies by varying phosphatase activity. We uncovered that SHP2 is a distinct class of
Externí odkaz:
https://doaj.org/article/8786074726574cf993ac21c17b758fad
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The testicular androgen biosynthesis is well understood, however, how cancer cells gauge dwindling androgen to dexterously initiate its de novo synthesis remained elusive. We uncover dual-phosphorylated form of sterol regulatory element-bind
Externí odkaz:
https://doaj.org/article/6796f1304f8b4aaf971cec547d08d83d
Autor:
Dhivya Sridaran, Surbhi Chouhan, Kiran Mahajan, Arun Renganathan, Cody Weimholt, Shambhavi Bhagwat, Melissa Reimers, Eric H. Kim, Manish K. Thakur, Muhammad A. Saeed, Russell K. Pachynski, Markus A. Seeliger, W. Todd Miller, Felix Y. Feng, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Immune checkpoint blockade is showing promise in cancer immune therapy, but many solid tumours are resistant. Authors here identify a pathway in T cells that leads to increased activity of C-terminal Src kinase, a negative regulator of T cell activit
Externí odkaz:
https://doaj.org/article/7caeec47da1c4212a9d6e0933f20b457
Autor:
Thanh Nguyen, Dhivya Sridaran, Surbhi Chouhan, Cody Weimholt, Audrey Wilson, Jingqin Luo, Tiandao Li, John Koomen, Bin Fang, Nagireddy Putluri, Arun Sreekumar, Felix Y. Feng, Kiran Mahajan, Nupam P. Mahajan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/bd78901281fb43119a54924b66bf7d3f
Autor:
Dhivya, Sridaran, Premkumar, Kumpati
Publikováno v:
In Critical Reviews in Oncology / Hematology February 2016 98:81-93
Autor:
Dhivya, Sridaran, Surbhi, Chouhan, Kiran, Mahajan, Arun, Renganathan, Cody, Weimholt, Shambhavi, Bhagwat, Melissa, Reimers, Eric H, Kim, Manish K, Thakur, Muhammad A, Saeed, Russell K, Pachynski, Markus A, Seeliger, W Todd, Miller, Felix Y, Feng, Nupam P, Mahajan
Publikováno v:
Nature communications. 13(1)
Solid tumours are highly refractory to immune checkpoint blockade (ICB) therapies due to the functional impairment of effector T cells and their inefficient trafficking to tumours. T-cell activation is negatively regulated by C-terminal Src kinase (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bb1b95b6964351bd22a60b1250a08b69
https://pubmed.ncbi.nlm.nih.gov/36376335
https://pubmed.ncbi.nlm.nih.gov/36376335
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(10)
During tumorigenesis, cancer cells generate complex, unresolved interactions with the surrounding oxystressed cellular milieu called tumor microenvironment (TM) that favors spread of cancer to other body parts. This dissemination of cancer cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c79f6f8d7609609dab8592a1a5c680
https://pubmed.ncbi.nlm.nih.gov/27460079
https://pubmed.ncbi.nlm.nih.gov/27460079
Prolonged cancer cell survival, acquiring drug resistance, and secondary cancer development despite chemotherapy are the major challenges during cancer treatment, whose underlying mechanism still remains elusive. In this study, low-doses of chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c56780688e48f60c65cf53497b907a99
https://europepmc.org/articles/PMC6062221/
https://europepmc.org/articles/PMC6062221/
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