Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Dhirendra P. Singh"'
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract The physiological quantum of stress-inducible transcriptional protein, Lens Epithelium-Derived Growth Factor (LEDGF), is vital for the maintenance of cellular physiology. Erratic epigenetic reprogramming in response to oxidative stress or wi
Externí odkaz:
https://doaj.org/article/3c758a821a094caaafc6c98ba87e2783
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 22, p 16276 (2023)
The continuum of antioxidant response dysregulation in aging/oxidative stress-driven Nlrp3 inflammasome activation-mediated inflammatory response is associated with age-related diseases. Peroxiredoxin (Prdx) 6 is a key antioxidant that provides cytop
Externí odkaz:
https://doaj.org/article/ca2d2c1a7468446cbe02cd384672f939
Publikováno v:
Antioxidants, Vol 12, Iss 1, p 140 (2023)
A major hallmark of aging-associated diseases is the inability to evoke cellular defense responses. Transcriptional protein Nrf2 (nuclear factor erythroid-derived 2-related factor) plays a pivotal role in the oxidative stress response, cellular homeo
Externí odkaz:
https://doaj.org/article/ad798a0d5d9a4605bb54115183f3fabf
Publikováno v:
Cells, Vol 12, Iss 1, p 74 (2022)
Decorin is an archetypal member of the small leucine-rich proteoglycan gene family and is involved in various biological functions and many signaling networks, interacting with extra-cellular matrix (ECM) components, growth factors, and receptor tyro
Externí odkaz:
https://doaj.org/article/c191976be069471a8243efecce22ae55
Publikováno v:
Cells, Vol 11, Iss 19, p 3021 (2022)
Increasing levels of oxidative-stress due to deterioration of the Nrf2 (NFE2-related factor)/ARE (antioxidant response element) pathway is found to be a primary cause of aging pathobiology. Metformin having anti-aging effects can delay/halt aging-rel
Externí odkaz:
https://doaj.org/article/cdedd725751a4761a1ebc1916c9cccf8
Publikováno v:
Cells, Vol 11, Iss 8, p 1266 (2022)
Changes in intracellular reactive oxygen species (ROS) levels due to remodeling of antioxidant defense can affect the status of biological homeostasis in aging/oxidative stress. Peroxiredoxin 6 (Prdx6), an antioxidant gene downstream target for the N
Externí odkaz:
https://doaj.org/article/0a5bd3742e9c463e974182e4f9f9a1ff
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1245 (2021)
Aberrant Sumoylation-mediated protein dysfunction is involved in a variety of oxidative and aging pathologies. We previously reported that Sumoylation-deficient Prdx6K(lysine)122/142R(Arginine) linked to the TAT-transduction domain gained stability a
Externí odkaz:
https://doaj.org/article/f910a2286a82431ab11ed746e2b3ea1f
Autor:
Shinsuke Shibata, Naoko Shibata, Satoshi Ohtsuka, Yasuo Yoshitomi, Etsuko Kiyokawa, Hideto Yonekura, Dhirendra P. Singh, Hiroshi Sasaki, Eri Kubo
Publikováno v:
Cells, Vol 10, Iss 4, p 863 (2021)
Decorin (DCN) is involved in a variety of physiological and pathological processes. Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) has been proposed as a major cause for the development of posterior capsule opacification (PCO
Externí odkaz:
https://doaj.org/article/b1defc46ba2541dfae72bf5265ff92d9
Publikováno v:
Cells, Vol 9, Iss 8, p 1861 (2020)
Many disorders of aging, including blinding-diseases, are associated with deficiency of brain and muscle arnt-like protein 1 (Bmal1) and, thereby, dysregulation of antioxidant-defense pathway. However, knowledge is limited regarding the role of Bmal1
Externí odkaz:
https://doaj.org/article/d4279f172b7a4ebd85882925dde5e5a4
Publikováno v:
Cells, Vol 8, Iss 10, p 1159 (2019)
Sulforaphane (SFN), an activator of transcription factor Nrf2 (NFE2-related factor), modulates antioxidant defense by Nrf2-mediated regulation of antioxidant genes like Peroxiredoxin 6 (Prdx6) and affects cellular homeostasis. We previously observed
Externí odkaz:
https://doaj.org/article/00443c10b74b474d97fbba6406abc90a