Investigation on the hereditary basis of colorectal cancers in an African population with frequent early onset cases.

Autor: Leolin Katsidzira, Anna Vorster, Innocent T Gangaidzo, Rudo Makunike-Mutasa, Dhiren Govender, Simbarashe Rusakaniko, Sandie Thomson, Jonathan A Matenga, Raj Ramesar

Publikováno v: PLoS ONE, Vol 14, Iss 10, p e0224023 (2019)

BackgroundApproximately 25% of colorectal cancer patients in sub-Saharan Africa are younger than 40 years, and hereditary factors may contribute. We investigated the frequency and patterns of inherited colorectal cancer among black Zimbabweans.Method

Externí odkaz: https://doaj.org/article/34860b9c519b44208730b48b38ad9fd6

Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population

Autor: Yee Wen Khew, Natalie J. Prescott, Dhiren Govender, Cathryn M. Lewis, Chantal Babb de Villiers, Elvira Singh, Ariella Amar, M. Iqbal Parker, Victoria Beynon, Wenlong C. Chen, Marco Matejcic, Christopher G. Mathew, Hannah Bye, Robyn Kerr

Publikováno v: Carcinogenesis
Chen, W C, Bye, H, Matejcic, M, Amar, A, Govender, D, Khew, Y W, Beynon, V, Kerr, R, Singh, E, Prescott, N J, Lewis, C M, Babb de Villiers, C, Parker, M I & Mathew, C G 2019, ' Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population ', Carcinogenesis, vol. 40, no. 4, bgz026, pp. 513-520 . https://doi.org/10.1093/carcin/bgz026

Oesophageal squamous cell carcinoma (OSCC) has a high incidence in southern Africa and a poor prognosis. Limited information is available on the contribution of genetic variants in susceptibility to OSCC in this region. However, recent genome-wide as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1057c3c913a649ed89c36e7f000cd71b
https://pubmed.ncbi.nlm.nih.gov/30753320

Abstract A12: Ethnic differences in the clinical and pathological characteristics of breast cancer among Kenyan women

Autor: Gretchen L. Gierach, Maya Palakal, Ronald Wasike, Dhiren Govender, Asim Jamal, Zahir Moloo, Mansoor N. Saleh, Shahin Sayed, Peter Bird

Publikováno v: Cancer Research. 77:A12-A12

Background: Breast cancer is the most common female malignancy worldwide. The effect of race and ethnicity on breast cancer has been the subject of much investigation. However, there are no published data from specific regions of sub-Saharan Africa w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c2c031df5cfa0d5e4d7222bc76e03c85
https://doi.org/10.1158/1538-7445.newfront17-a12

Tuberculous anal fistulas--prevalence and clinical features in an endemic area

Autor: Douglas, Stupart, Paul, Goldberg, Anthony, Levy, Dhiren, Govender

Publikováno v: South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie. 47(4)

The aim of this study was to determine the prevalence of tuberculosis (TB) in anal fistulas at a referral hospital in Cape Town, and to document the clinical features and course of patients with tuberculous anal fistulas.This was a prospective study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e1aa2b15cf44abc892cba42a8d25436
https://pubmed.ncbi.nlm.nih.gov/20141068

Crohn's Disease-Associated Small Bowel Adenocarcinoma With Pre-Existing Low-Grade Dysplasia: A Case Report

Autor: Gill Watermeyer, Anwar Suleman Mall, Dhiren Govender, Michael Locketz

Publikováno v: The American Journal of Gastroenterology. 102:1545-1546

Crohn's Disease-Associated Small Bowel Adenocarcinoma With Pre-Existing Low-Grade Dysplasia: A Case Report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::478043742ff0d6bc6bf1cde7f2575031
https://doi.org/10.1111/j.1572-0241.2007.01166.x