Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Dhiral P Phadke"'
Publikováno v:
Bioinformatics and Biology Insights, Vol 16 (2022)
High-throughput transcriptomics has advanced through the introduction of TempO-seq, a targeted alternative to traditional RNA-seq. TempO-seq platforms use 50 nucleotide probes, each specifically designed to target a known transcript, thus allowing fo
Externí odkaz:
https://doaj.org/article/8b28616d97a847abbaf8053d0e0e327a
Autor:
Deepak Mav, Dhiral P Phadke, Michele R Balik-Meisner, B Alex Merrick, Scott Auerbach, Marije Niemeijer, Suzanna Huppelschoten, Audrey Baze, Celine Parmentier, Lysiane Richert, Bob van de Water, Ruchir R Shah, Richard S Paules
Publikováno v:
Bioinformatics and Biology Insights, Vol 14 (2020)
The TempO-Seq S1500+ platform(s), now available for human, mouse, rat, and zebrafish, measures a discrete number of genes that are representative of biological and pathway co-regulation across the entire genome in a given species. While measurement o
Externí odkaz:
https://doaj.org/article/d6f389cb95e54e188488ba1e4c1a51c4
Autor:
B Alex Merrick, Justin S Chang, Dhiral P Phadke, Meredith A Bostrom, Ruchir R Shah, Xinguo Wang, Oksana Gordon, Garron M Wright
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0190992 (2018)
The transcriptome can reveal insights into precancer biology. We recently conducted RNA-Seq analysis on liver RNA from male rats exposed to the carcinogen, aflatoxin B1 (AFB1), for 90 days prior to liver tumor onset. Among >1,000 differentially expre
Externí odkaz:
https://doaj.org/article/25bd8608d23d4629a3f9705634361845
Autor:
Archana Hari, Mohamed Diwan M. AbdulHameed, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Elizabeth H. Scholl, Ruchir R. Shah, Warren Casey, Scott S. Auerbach, Anders Wallqvist, Venkat R. Pannala
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Toxicants with the potential to bioaccumulate in humans and animals have long been a cause for concern, particularly due to their association with multiple diseases and organ injuries. Per- and polyfluoro alkyl substances (PFAS) and polycyclic aromat
Externí odkaz:
https://doaj.org/article/8fa9b6200c834987838ec3cbd001cc10
Autor:
B Alex Merrick, Dhiral P Phadke, Scott S Auerbach, Deepak Mav, Suzy M Stiegelmeyer, Ruchir R Shah, Raymond R Tice
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61768 (2013)
Deep sequencing was used to investigate the subchronic effects of 1 ppm aflatoxin B1 (AFB1), a potent hepatocarcinogen, on the male rat liver transcriptome prior to onset of histopathological lesions or tumors. We hypothesized RNA-Seq would reveal mo
Externí odkaz:
https://doaj.org/article/a3b59a1659ee46fb996fa3a880f22e55
Autor:
Venkat R. Pannala, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Elizabeth H. Scholl, Ruchir R. Shah, Scott S. Auerbach, Anders Wallqvist
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 7108 (2024)
In the original publication [...]
Externí odkaz:
https://doaj.org/article/ab23c3e9cc364b5db708d4dfd90f396c
Publikováno v:
Genomic and Epigenomic Biomarkers of Toxicology and Disease. :395-413
Autor:
Fred Parham, B Collins, Barney Sparrow, Stephen S. Ferguson, William M. Gwinn, Scott S. Auerbach, Nick Machesky, Jenni Gorospe, Deepak Mav, Michele R Balik-Meisner, Esra Mutlu, Richard S. Paules, Sreenivasa Ramaiahgari, Michael J. DeVito, Ruchir R. Shah, John R. Bucher, Matthew D. Stout, Heather Toy, Suramya Waidyanatha, Georgia K. Roberts, Dhiral P. Phadke, Bruce Alex Merrick
Publikováno v:
Toxicol Sci
A 5-day in vivo rat model was evaluated as an approach to estimate chemical exposures that may pose minimal risk by comparing benchmark dose (BMD) values for transcriptional changes in the liver and kidney to BMD values for toxicological endpoints fr
Autor:
Bevin E. Blake, Colette N. Miller, Helen Nguyen, Vesna A. Chappell, Trina P. Phan, Dhiral P. Phadke, Michele R. Balik-Meisner, Deepak Mav, Ruchir R. Shah, Suzanne E. Fenton
Publikováno v:
Ecotoxicology and Environmental Safety. 248:114314
Per- and polyfluoroalkyl substances (PFAS) comprise a diverse class of chemicals used in industrial processes, consumer products, and fire-fighting foams which have become environmental pollutants of concern due to their persistence, ubiquity, and as
Autor:
Julie F. Foley, Ruchir R. Shah, B. Alex Merrick, Molly E. Cook, Jason A. Malphurs, Michael B. Fessler, Brian Elgart, Frederick J.W. Miller, Dhiral P. Phadke, Kevin E. Gerrish, Gregory G. Solomon
Publikováno v:
Physiological Reports
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)
Cell‐free DNA circulates in plasma at low levels as a normal by‐product of cellular apoptosis. Multiple clinical pathologies, as well as environmental stressors can lead to increased circulating cell‐free DNA (ccfDNA) levels. Plasma DNA studies