Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Dhiraj K. Singh"'
Autor:
Mayuresh M. Abhyankar, Feifan Xu, Deborah Chavez, Anna Goodroe, Elda Mendoza, Christopher Chen, Dhiraj K. Singh, Fernando Varnador, Sandra J. Sivananthan, Robert Kinsey, William R. Lykins, Brynn M. Murphy, Andrew R. Martin, Mark A. Tomai, Soutik Ghosal, Corey Casper, Karl Pedersen, William A. Petri, Christopher B. Fox
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 20, Iss 1 (2024)
Entamoeba histolytica, the causative agent of amebiasis, is one of the top three parasitic causes of mortality worldwide. However, no vaccine exists against amebiasis. Using a lead candidate vaccine containing the LecA fragment of Gal-lectin and GLA-
Externí odkaz:
https://doaj.org/article/551da17c7f22488f90dafec622622cb9
Autor:
Dhiraj K. Singh, Ekaterina Aladyeva, Shibali Das, Bindu Singh, Ekaterina Esaulova, Amanda Swain, Mushtaq Ahmed, Journey Cole, Chivonne Moodley, Smriti Mehra, Larry S. Schlesinger, Maxim N. Artyomov, Shabaana A. Khader, Deepak Kaushal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
To gain insights into the early immune dynamics of transcriptional changes during SARS-CoV-2 infection, Singh et al. provide longitudinal scRNA-Seq of the broncho-alveolar compartment of SARS-CoV-2 infected rhesus macaques. They observe an accumulati
Externí odkaz:
https://doaj.org/article/ae41ab4ead8645a8baa2d47cebcd2017
Publikováno v:
Pathogens, Vol 12, Iss 9, p 1120 (2023)
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in HIV-infected persons, with one in four deaths attributable to TB. While the majority of healthy indiv
Externí odkaz:
https://doaj.org/article/b107b8cff3b440998af90ea7eb5fefca
Autor:
Bindu Singh, Chivonne Moodley, Dhiraj K. Singh, Ruby A. Escobedo, Riti Sharan, Garima Arora, Shashank R. Ganatra, Vinay Shivanna, Olga Gonzalez, Shannan Hall-Ursone, Edward J. Dick Jr., Deepak Kaushal, Xavier Alvarez, Smriti Mehra
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. IDO expressio
Externí odkaz:
https://doaj.org/article/59e3a53626764aa2a1294a8cc4c559ab
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mycobacterium tuberculosis (Mtb) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb infection in
Externí odkaz:
https://doaj.org/article/f576a799959f43c1a05a238f69930f9c
Autor:
Riti Sharan, Shashank R. Ganatra, Dhiraj K. Singh, Journey Cole, Taylor W. Foreman, Rajesh Thippeshappa, Charles A. Peloquin, Vinay Shivanna, Olga Gonzalez, Cheryl L. Day, Neel R. Gandhi, Edward J. Dick Jr., Shannan Hall-Ursone, Smriti Mehra, Larry S. Schlesinger, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria in macaques
Externí odkaz:
https://doaj.org/article/659732e8266a421b8e6775d23db444b0
Autor:
Bruce A. Rosa, Mushtaq Ahmed, Dhiraj K. Singh, José Alberto Choreño-Parra, Journey Cole, Luis Armando Jiménez-Álvarez, Tatiana Sofía Rodríguez-Reyna, Bindu Singh, Olga Gonzalez, Ricardo Carrion, Larry S. Schlesinger, John Martin, Joaquín Zúñiga, Makedonka Mitreva, Deepak Kaushal, Shabaana A. Khader
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Rosa et al. find that genes associated with Interferon (IFN) signaling, neutrophil degranulation and innate immune pathways are induced in the lungs of macaques in response to SARS-CoV-2 infection, whereas genes associated with collagen formation and
Externí odkaz:
https://doaj.org/article/fee1d848484c4499aa50fa45ecb7d32f
Autor:
Riti Sharan, Shashank R. Ganatra, Allison N. Bucsan, Journey Cole, Dhiraj K. Singh, Xavier Alvarez, Maya Gough, Cynthia Alvarez, Alyssa Blakley, Justin Ferdin, Rajesh Thippeshappa, Bindu Singh, Ruby Escobedo, Vinay Shivanna, Edward J. Dick Jr., Shannan Hall-Ursone, Shabaana A. Khader, Smriti Mehra, Jyothi Rengarajan, Deepak Kaushal
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 3 (2022)
Studies using the nonhuman primate model of Mycobacterium tuberculosis/simian immunodeficiency virus coinfection have revealed protective CD4+ T cell–independent immune responses that suppress latent tuberculosis infection (LTBI) reactivation. In p
Externí odkaz:
https://doaj.org/article/3b5a3287ec7841488006eb98b7de9d18
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
Coronavirus disease 2019 (COVID-19) is a highly contagious, infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in late 2019 in Wuhan China. A year after the World Health Organization declared COVI
Externí odkaz:
https://doaj.org/article/c0c796a46ffc4d44893100b44a42fdea
Autor:
Bindu Singh, Dhiraj K. Singh, Shashank R. Ganatra, Ruby A. Escobedo, Shabaana Khader, Larry S. Schlesinger, Deepak Kaushal, Smriti Mehra
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT Myeloid-derived suppressor cells (MDSCs) represent an innate immune cell population comprised of immature myeloid cells and myeloid progenitors with very potent immunosuppressive potential. MDSCs are reported to be abundant in the lungs of a
Externí odkaz:
https://doaj.org/article/644066ee09bb44d990f99993796d59a1