Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Dhimant Desai"'
SelSA-1, a novel HDAC inhibitor demonstrates enhanced chemotherapeutic potential by redox modulation
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Colorectal cancer (CRC) is a multistep disorder resulting from genetic and epigenetic genome changes. It is the third most common malignancy in developed nations accounting for roughly 600,000 deaths annually. Persistent gut inflammation, as
Externí odkaz:
https://doaj.org/article/f95f036b530d4f209f6428e7a40f3631
Autor:
Jie Jiang, Yuandi Ma, Yameng Liu, Dasheng Lu, Xiaoxia Gao, Kristopher W. Krausz, Dhimant Desai, Shantu G. Amin, Andrew D. Patterson, Frank J. Gonzalez, Cen Xie
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3363-3378 (2022)
Abstract Nonalcoholic steatohepatitis (NASH) is a rapidly developing pathology around the world, with limited treatment options available. Some farnesoid X receptor (FXR) agonists have been applied in clinical trials for NASH, but side effects such a
Externí odkaz:
https://doaj.org/article/015ef893a39043a2b1037cb81bef5aab
Autor:
Wesley M. Raup-Konsavage, Diana E. Sepulveda, Daniel P. Morris, Shantu Amin, Kent E. Vrana, Nicholas M. Graziane, Dhimant Desai
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1869 (2022)
(1) Background: Recently, a number of side chain length variants for tetrahydrocannabinol and cannabidiol have been identified in cannabis; however, the precursor to these molecules would be based upon cannabigerol (CBG). Because CBG, and its side ch
Externí odkaz:
https://doaj.org/article/a89190cda6d64ddfa99cf6a13b430b30
Autor:
Su-Fern Tan, Wendy Dunton, Xin Liu, Todd E. Fox, Samy A.F. Morad, Dhimant Desai, Kenichiro Doi, Mark R. Conaway, Shantu Amin, David F. Claxton, Hong-Gang Wang, Mark Kester, Myles C. Cabot, David J. Feith, Thomas P. Loughran, Jr.
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 6, Pp 1078-1086 (2019)
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. More than half of older AML patients fail to respond to cytotoxic chemotherapy, and most responders relapse with drug-resistant disease. Failure to achieve complete remission c
Externí odkaz:
https://doaj.org/article/a185154e7e4d47c99c08cbdef0bdcbba
Autor:
Shaneice K. Nettleford, Luming Zhao, Fenghua Qian, Morgan Herold, Brooke Arner, Dhimant Desai, Shantu Amin, Na Xiong, Vishal Singh, Bradley A. Carlson, K. Sandeep Prabhu
Publikováno v:
Frontiers in Nutrition, Vol 7 (2020)
Enteropathogenic Escherichia coli (EPEC) leads to adverse colonic inflammation associated with poor resolution of inflammation and loss of epithelial integrity. Micronutrient trace element selenium (Se) is incorporated into selenoproteins as the 21st
Externí odkaz:
https://doaj.org/article/b25d7fd4c6cf4d26814b4c5c0fcb8106
Autor:
Charyguly Annageldiyev, Su-Fern Tan, Shreya Thakur, Pavan Kumar Dhanyamraju, Srinivasa R. Ramisetti, Preeti Bhadauria, Jacob Schick, Zheng Zeng, Varun Sharma, Wendy Dunton, Sinisa Dovat, Dhimant Desai, Hong Zheng, David J. Feith, Thomas P. Loughran, Shantu Amin, Arun K. Sharma, David Claxton, Arati Sharma
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Acute myeloid leukemia is a heterogeneous disease with a 5-year survival rate of 28.3%, and current treatment options constrained by dose-limiting toxicities. One of the key signaling pathways known to be frequently activated and dysregulated in AML
Externí odkaz:
https://doaj.org/article/91cfc78f3e9d4b93afe1dfa050439f7e
Autor:
Charyguly Annageldiyev, Krishne Gowda, Trupti Patel, Priyanjali Bhattacharya, Su-Fern Tan, Soumya Iyer, Dhimant Desai, Sinisa Dovat, David J. Feith, Thomas P. Loughran, Shantu Amin, David Claxton, Arati Sharma
Publikováno v:
Haematologica, Vol 105, Iss 3 (2020)
Leukemic stem cells are multipotent, self-renewing, highly proliferative cells that can withstand drug treatments. Although currently available treatments potentially destroy blast cells, they fail to eradicate leukemic progenitor cells completely. A
Externí odkaz:
https://doaj.org/article/9c54a0d0960441b19e406ddebb6ad8a6
Autor:
Saumya Maru, Ge Jin, Dhimant Desai, Shantu Amin, Shwetank, Matthew D. Lauver, Aron E. Lukacher
Publikováno v:
mSphere, Vol 2, Iss 6 (2017)
ABSTRACT Polyomaviruses (PyVs) silently infect most humans, but they can cause life-threatening diseases in immunocompromised individuals. The JC polyomavirus (JCPyV) induces progressive multifocal leukoencephalopathy, a severe demyelinating disease
Externí odkaz:
https://doaj.org/article/3b923e5220f04016ad822ffe94ceefcb
Autor:
Chinthalapally V. Rao, Jagan Mohan R. Patlolla, Li Qian, Yuting Zhang, Misty Brewer, Altaf Mohammed, Dhimant Desai, Shantu Amin, Stan Lightfoot, Levy Kopelovich
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 9, Pp 1018-1027 (2013)
Lung cancer is the leading cause of cancer deaths worldwide. Expression of the p53 tumor suppressor protein is frequently altered in tobacco-associated lung cancers. We studied chemopreventive effects of p53-modulating agents, namely, CP-31398 and Pr
Externí odkaz:
https://doaj.org/article/0873f21ea9274aa3869bada025d830cb
Autor:
Hephzibah Rani S. Tagaram, Dhimant Desai, Guangfu Li, Dai Liu, C. Bart Rountree, Kavitha Gowda, Arthur Berg, Shantu Amin, Kevin F. Staveley-O’Carroll, Eric T. Kimchi
Publikováno v:
Pharmaceuticals, Vol 9, Iss 2, p 18 (2016)
Hepatocellular carcinoma (HCC) is the third most deadly cancer in the world. New treatment strategies are desperately needed due to limited standard therapies. Activation of the Erk, Akt, and STAT3pathways is implicated in the prognosis of HCC. The S
Externí odkaz:
https://doaj.org/article/78fa283f47714a8fbf9ad85d01c6f709