Combining Host Genetics and Functional Analysis to Depict Inflammasome Contribution in Tuberculosis Susceptibility and Outcome in Endemic Areas

Autor: Dhêmerson Souza De Lima, Caio C. B. Bomfim, Vinícius N. C. Leal, Edione C. Reis, Jaíne L. S. Soares, Fernanda P. Fernandes, Eduardo P. Amaral, Flavio V. Loures, Mauricio M. Ogusku, Maria R. D'Imperio Lima, Aya Sadahiro, Alessandra Pontillo

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The interplay between M. tuberculosis (Mtb) and humans is multifactorial. The susceptibility/resistance profile and the establishment of clinical tuberculosis (TB) still remains elusive. The gain-of-function variant rs10754558 in the NLRP3 gene (foun

Externí odkaz: https://doaj.org/article/365d9913d57042b2a2515ba4ec720468

Alleles of HLA-DRB1*04 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population.

Autor: Dhêmerson Souza de Lima, Mauricio Morishi Ogusku, Maisa Porto Dos Santos, Cláudia Maria de Melo Silva, Vanessa Alves de Almeida, Irineide Assumpção Antunes, Antonio Luiz Boechat, Rajendranath Ramasawmy, Aya Sadahiro

Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0147543 (2016)

Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1*04 alleles to identify subtypes associated with pulmonary TB an

Externí odkaz: https://doaj.org/article/8ca72cba01424ef69fdbbe09a243b14f

Sensing soluble uric acid by Naip1-Nlrp3 platform

Autor: Tarcio Teodoro Braga, Mariana Rodrigues Davanso, Davi Mendes, Tiago Antonio de Souza, Anderson Fernandes de Brito, Mario Costa Cruz, Meire Ioshie Hiyane, Dhemerson Souza de Lima, Vinicius Nunes, Juliana de Fátima Giarola, Denio Emanuel Pires Souto, Tomasz Próchnicki, Mario Lauterbach, Stellee Marcela Petris Biscaia, Rilton Alves de Freitas, Rui Curi, Alessandra Pontillo, Eicke Latz, Niels Olsen Saraiva Camara

Publikováno v: Cell Death and Disease, Vol 12, Iss 2, Pp 1-14 (2021)

Abstract Uric acid (UA), a product of purine nucleotide degradation able to initiate an immune response, represents a breakpoint in the evolutionary history of humans, when uricase, the enzyme required for UA cleavage, was lost. Despite being inert i

Externí odkaz: https://doaj.org/article/c9c3bd06ba4c49ea8db5a12ffc2f75cd

Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung

Autor: Nicolas Chamberlain, Mona Ruban, Zoe F. Mark, Sierra R. Bruno, Amit Kumar, Ravishankar Chandrasekaran, Dhemerson Souza De Lima, Danielle Antos, Emily M. Nakada, John F. Alcorn, Vikas Anathy

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1078
International Journal of Molecular Sciences, Vol 23, Iss 1078, p 1078 (2022)

Influenza (IAV) neuraminidase (NA) is a glycoprotein required for the viral exit from the cell. NA requires disulfide bonds for proper function. We have recently demonstrated that protein disulfide isomerase (PDI)A3 is required for oxidative folding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4d5f76168b2e44e880e87a0b6302aa
https://pubmed.ncbi.nlm.nih.gov/35162999

Single-Nucleotide Variants in the AIM2 – Absent in Melanoma 2 Gene (rs1103577) Associated With Protection for Tuberculosis

Autor: Mariana Brasil de Andrade Figueira, Dhêmerson Souza de Lima, Antonio Luiz Boechat, Milton Gomes do Nascimento Filho, Irineide Assumpção Antunes, Joycenéa da Silva Matsuda, Thaís Rodrigues de Albuquerque Ribeiro, Luana Sousa Felix, Ariane Senna Fonseca Gonçalves, Allyson Guimarães da Costa, Rajendranath Ramasawmy, Alessandra Pontillo, Mauricio Morishi Ogusku, Aya Sadahiro

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Tuberculosis (TB) remains a serious public health burden worldwide. TB is an infectious disease caused by the Mycobacterium tuberculosis Complex. Innate immune response is critical for controlling mycobacterial infection. NOD-like receptor pyrin doma

Externí odkaz: https://doaj.org/article/5afca8f0521a4c6d81f745054d56062f