Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Dheerendra Gupta"'
Autor:
Ahmed Elwakiel, Dheerendra Gupta, Rajiv Rana, Jayakumar Manoharan, Moh’d Mohanad Al-Dabet, Saira Ambreen, Sameen Fatima, Silke Zimmermann, Akash Mathew, Zhiyang Li, Kunal Singh, Anubhuti Gupta, Surinder Pal, Alba Sulaj, Stefan Kopf, Constantin Schwab, Ronny Baber, Robert Geffers, Tom Götze, Bekas Alo, Christina Lamers, Paul Kluge, Georg Kuenze, Shrey Kohli, Thomas Renné, Khurrum Shahzad, Berend Isermann
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Coagulation factor XII (FXII) conveys various functions as an active protease that promotes thrombosis and inflammation, and as a zymogen via surface receptors like urokinase-type plasminogen activator receptor (uPAR). While plasma levels of
Externí odkaz:
https://doaj.org/article/2ce97d19ca754507a003d6b16a5ab8c0
Autor:
Moh’d Mohanad Al-Dabet, Khurrum Shahzad, Ahmed Elwakiel, Alba Sulaj, Stefan Kopf, Fabian Bock, Ihsan Gadi, Silke Zimmermann, Rajiv Rana, Shruthi Krishnan, Dheerendra Gupta, Jayakumar Manoharan, Sameen Fatima, Sumra Nazir, Constantin Schwab, Ronny Baber, Markus Scholz, Robert Geffers, Peter Rene Mertens, Peter P. Nawroth, John H. Griffin, Maria Keller, Chris Dockendorff, Shrey Kohli, Berend Isermann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Persistent diabetic complications despite controlled blood glucose levels, known as hyperglycemic memory, remain a poorly understood phenomenon in diabetic kidney disease. Here the authors identify senescence-associated gene p21 as a regulator of hyp
Externí odkaz:
https://doaj.org/article/e0c24968fbe44886ac4eb5d91d955ed8
Autor:
Sameen Fatima, Saira Ambreen, Akash Mathew, Ahmed Elwakiel, Anubhuti Gupta, Kunal Singh, Shruthi Krishnan, Rajiv Rana, Hamzah Khawaja, Dheerendra Gupta, Jayakumar Manoharan, Christian Besler, Ulrich Laufs, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Publikováno v:
Nutrients, Vol 14, Iss 14, p 2786 (2022)
Diabetes mellitus is hallmarked by accelerated atherosclerosis, a major cause of mortality among patients with diabetes. Efficient therapies for diabetes-associated atherosclerosis are absent. Accelerated atherosclerosis in diabetic patients is assoc
Externí odkaz:
https://doaj.org/article/ec503a51966044dc9cec6c79c8332b5d
Autor:
Rajiv Rana, Jayakumar Manoharan, Anubhuti Gupta, Dheerendra Gupta, Ahmed Elwakiel, Hamzah Khawaja, Sameen Fatima, Silke Zimmermann, Kunal Singh, Saira Ambreen, Ihsan Gadi, Ronald Biemann, Shihai Jiang, Khurrum Shahzad, Shrey Kohli, Berend Isermann
Publikováno v:
Nutrients, Vol 14, Iss 15, p 3138 (2022)
Diabetic kidney disease (DKD) is an emerging pandemic, paralleling the worldwide increase in obesity and diabetes mellitus. DKD is now the most frequent cause of end-stage renal disease and is associated with an excessive risk of cardiovascular morbi
Externí odkaz:
https://doaj.org/article/7a6b09045ec2498d80474223e4c38fcd
Autor:
Abdul Ahad, Mathias Stevanin, Shuchi Smita, Gyan Prakash Mishra, Dheerendra Gupta, Sebastian Waszak, Uday Aditya Sarkar, Soumen Basak, Bhawna Gupta, Hans Acha-Orbea, Sunil Kumar Raghav
Publikováno v:
iScience, Vol 19, Iss , Pp 996-1011 (2019)
Summary: Understanding the mechanisms fine-tuning immunogenic versus tolerogenic balance in dendritic cells (DCs) is of high importance for therapeutic approaches. We found that NCoR1-mediated direct repression of the tolerogenic program in conventio
Externí odkaz:
https://doaj.org/article/9a0a4533b0ae447088b917f3ac87d2c9
Autor:
Saira Ambreen, Sameen Fatima, Ahmed Elwakiel, Rajiv Rana, Kunal Singh, Anubhuti Gupta, Dheerendra Gupta, Hamzah Khawaja, Jayakumar Manoharan, Christian Besler, Ulrich Laufs, Shrey Kohli, Berend Isermann, Khurrum Shahzad
Publikováno v:
Nutrients, Vol 14, Iss 10, p 1991 (2022)
Diabetes mellitus, which is largely driven by nutritional and behavioral factors, is characterized by accelerated atherosclerosis with impaired plaque stability. Atherosclerosis and associated complications are the major cause of mortality in diabeti
Externí odkaz:
https://doaj.org/article/9cb05a37a4304026bb0c2631ff857fed
Autor:
Satish Ranjan, Alexander Goihl, Shrey Kohli, Ihsan Gadi, Mandy Pierau, Khurrum Shahzad, Dheerendra Gupta, Fabian Bock, Hongjie Wang, Haroon Shaikh, Thilo Kähne, Dirk Reinhold, Ute Bank, Ana C. Zenclussen, Jana Niemz, Tina M. Schnöder, Monika Brunner-Weinzierl, Thomas Fischer, Thomas Kalinski, Burkhart Schraven, Thomas Luft, Jochen Huehn, Michael Naumann, Florian H. Heidel, Berend Isermann
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Graft-vs.-host disease is a complication of allogenic hematopoietic stem cell transplantation, and is associated with endothelial dysfunction. Here the authors show that activated protein C signals via PAR2/PAR3 to expand Treg cells, mitigating the d
Externí odkaz:
https://doaj.org/article/17c58ccb118041e9a3a369a75450a669
Autor:
Abdul Ahad, Mathias Stevanin, Shuchi Smita, Gyan P. Mishra, Dheerendra Gupta, Sebastian M. Waszak, Bhawna Gupta, Hans Acha-Orbea, Sunil K. Raghav
Publikováno v:
Canadian Journal of Biotechnology, Vol 1, Iss Special Issue, Pp 161-161 (2017)
The therapeutic potential of tolerogenic dendritic cells (DCs) for autoimmune disorders and transplantation has been widely proposed. We show here for the first time that nuclear receptor co-repressor 1 (NCoR1) strongly represses the tolerogenic prog
Externí odkaz:
https://doaj.org/article/92813632bc384215a23c5a31a080c387
Autor:
Matthias Ruebner, Rajiv Rana, Berend Isermann, Dheerendra Gupta, Kunal Kumar Singh, Ahmed Elwakiel, Paulina Markmeyer, Franziska Lochmann, Shrey Kohli, Hanna Huebner, Anubhuti Gupta
Publikováno v:
Blood
Excess platelet activation by extracellular vesicles (EVs) results in trophoblast inflammasome activation, interleukin 1β (IL-1β) activation, preeclampsia (PE), and partial embryonic lethality. Embryonic thrombomodulin (TM) deficiency, which causes
Autor:
Shruthi Krishnan, Jayakumar Manoharan, Hongjie Wang, Dheerendra Gupta, Sameen Fatima, Yanfei Yu, Akash Mathew, Zhen Li, Shrey Kohli, Constantin Schwab, Antje Körner, Peter R. Mertens, Peter Nawroth, Khurrum Shahzad, Michael Naumann, Berend Isermann, Ronald Biemann
Publikováno v:
Kidney international.
Dysfunction of mesangial cells plays a major role in the pathogenesis of diabetic kidney disease (DKD), the leading cause of kidney failure. However, the underlying molecular mechanisms are incompletely understood. By unbiased gene expression analysi