Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Dhaval K Shah"'
Autor:
Miaomiao Li, Chih Yean Ong, Christophe J Langouët-Astrié, Lisi Tan, Ashwni Verma, Yimu Yang, Xiaoxiao Zhang, Dhaval K Shah, Eric P Schmidt, Ding Xu
Publikováno v:
eLife, Vol 11 (2022)
RAGE, a druggable inflammatory receptor, is known to function as an oligomer but the exact oligomerization mechanism remains poorly understood. Previously we have shown that heparan sulfate (HS) plays an active role in RAGE oligomerization. To unders
Externí odkaz:
https://doaj.org/article/fd4241c108454ee0ac24b569c2771b24
Publikováno v:
Pharmaceutics, Vol 16, Iss 10, p 1259 (2024)
Objective: This study aimed to investigate the effect of molecular size on the pulmonary pharmacokinetics (PK) of proteins following systemic and local administration in wild-type mice. Methods: A non-cross-reactive antibody trastuzumab, and F(ab′)
Externí odkaz:
https://doaj.org/article/e5f84f60190e4daca7287ea24db21f88
Publikováno v:
Antibodies, Vol 13, Iss 3, p 54 (2024)
The objective of this work was to develop a population physiologically based pharmacokinetic (popPBPK) model to characterize the variability in the clinical PK of monoclonal antibodies (mAbs) following intravenous (IV) and subcutaneous (SC) administr
Externí odkaz:
https://doaj.org/article/4d4ef3d8ee3248c5b3da7155bb7e3fd2
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-21 (2022)
Abstract A demonstration is provided on how algorithmic asymptotic analysis of multi-scale pharmacokinetics (PK) systems can provide (1) system level understanding and (2) predictions on the response of the model when parameters vary. Being algorithm
Externí odkaz:
https://doaj.org/article/4e01ec1ce6e741b69beb1b905bacaf94
Autor:
Jakob C. Stüber, Karin F. Rechberger, Saša M. Miladinović, Thomas Pöschinger, Tamara Zimmermann, Remi Villenave, Miro J. Eigenmann, Thomas E. Kraft, Dhaval K. Shah, Hubert Kettenberger, Wolfgang F. Richter
Publikováno v:
AAPS Open, Vol 8, Iss 1, Pp 1-18 (2022)
Abstract This study explores the impact of antibody surface charge on tissue distribution into various tissues including tumor. Tumor-bearing mice were dosed intravenously with a mixture comprising three antibodies engineered to carry negative charge
Externí odkaz:
https://doaj.org/article/7356f1aec7b84b8489b40eb563178c52
Autor:
Marc C. Huisman, C. Willemien Menke-van der Houven van Oordt, Josée M. Zijlstra, Otto S. Hoekstra, Ronald Boellaard, Guus A. M. S. van Dongen, Dhaval K. Shah, Yvonne W. S. Jauw
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-7 (2021)
Abstract Background 89Zirconium-immuno-positron emission tomography (89Zr-immuno-PET) is used for assessment of target status to guide antibody-based therapy. We aim to determine the relation between antibody tumor uptake and target concentration to
Externí odkaz:
https://doaj.org/article/7ca500900e7d40a997a3ff94b199da2c
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1132 (2023)
We hypothesize that different routes of administration may lead to altered pharmacokinetics/pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to improve their therapeutic index. To evaluate this hypothesis, here we per
Externí odkaz:
https://doaj.org/article/69d67a523994457c9d0fe5d412c7292b
Autor:
Lyndsey F. Meyer, Dhaval K. Shah
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 9, Iss 3, Pp 163-169 (2019)
Here we have presented a sensitive and selective LC-MS/MS method for the quantification of tyrphostin A9, which is a selective inhibitor for platelet derived growth factor receptor tyrosine kinase and has been investigated in vitro as a potent oxidat
Externí odkaz:
https://doaj.org/article/d5ee2b1d7a0543ae92e7cfd3bda714aa
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 3, Pp 177-187 (2019)
Bispecific antibodies (BsAbs) bind to two different targets, and create two binary and one ternary complex (TC). These molecules have shown promise as immuno‐oncology drugs, and the TC is considered the pharmacologically active species that drives
Externí odkaz:
https://doaj.org/article/5aed68d921f74369bb5940b4b637b41b
Publikováno v:
ACS Omega. 8:11201-11212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea210cf27fee17f2b1c5af5ecddfe190
https://doi.org/10.1021/acsomega.2c08100
https://doi.org/10.1021/acsomega.2c08100