Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Dhasakumar S. Navaratnam"'
Autor:
Matthew R. Fleming, Maile R. Brown, Jack Kronengold, Yalan Zhang, David P. Jenkins, Gulia Barcia, Rima Nabbout, Anne E. Bausch, Peter Ruth, Robert Lukowski, Dhasakumar S. Navaratnam, Leonard K. Kaczmarek
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2281-2288 (2016)
Human mutations in the cytoplasmic C-terminal domain of Slack sodium-activated potassium (KNa) channels result in childhood epilepsy with severe intellectual disability. Slack currents can be increased by pharmacological activators or by phosphorylat
Externí odkaz:
https://doaj.org/article/2cfbf9c489e94d12aaac50269099564c
Autor:
Daniela Renedo, Nanthiya Sujijantarat, Joseph Antonios, Andrew Koo, Julian Acosta, Guido J Falcone, Ryan Hebert, Lauren H Sansing, Dhasakumar S Navaratnam, Charles Matouk
Publikováno v:
Stroke. 54
Background: Mechanical thrombectomy (MT) has significantly improved clinical outcomes in acute ischemic stroke. We used single-cell RNA sequencing (scRNA-seq) to describe the landscape of human clots at single cell resolution seeking to provide great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee0238c61d32a71fdc4a90e07823670f
https://doi.org/10.1161/str.54.suppl_1.15
https://doi.org/10.1161/str.54.suppl_1.15
Autor:
Yifan Zhang, Iman Moeini-Naghani, JunPing Bai, Joseph Santos-Sacchi, Dhasakumar S. Navaratnam
Publikováno v:
Biology Open, Vol 4, Iss 2, Pp 197-205 (2015)
Prestin is targeted to the lateral wall of outer hair cells (OHCs) where its electromotility is critical for cochlear amplification. Using MDCK cells as a model system for polarized epithelial sorting, we demonstrate that prestin uses tyrosine residu
Externí odkaz:
https://doaj.org/article/e89caefe8c234f5fade26200b96cc2b9
Autor:
Michael C. Stankewich, Jun-Ping Bai, Paul R. Stabach, Saaim Khan, Winston J.T. Tan, Alexei Surguchev, Lei Song, Jon S. Morrow, Joseph Santos-Sacchi, Dhasakumar S. Navaratnam
Publikováno v:
Hearing Research. 423:108564
Reports have proposed a putative role for βV spectrin in outer hair cells (OHCs) of the cochlea. In an ongoing investigation of the role of the cytoskeleton in electromotility, we tested mice with a targeted exon deletion of βV spectrin (Spnb5), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f59f0fa4c50f300838be0590e6f17d8
https://doi.org/10.1016/j.heares.2022.108564
https://doi.org/10.1016/j.heares.2022.108564
Autor:
Shumin Bian, Jun-Ping Bai, Hannah Chapin, Cathy Le Moellic, Huiping Dong, Michael Caplan, Fred J Sigworth, Dhasakumar S Navaratnam
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28264 (2011)
The large conductance calcium-activated potassium channel alpha-subunit (Slo) is widely distributed throughout the body and plays an important role in a number of diseases. Prior work has shown that Slo, through its S10 region, interacts with β-cate
Externí odkaz:
https://doaj.org/article/872d8c2dab444a94bec1b6facabce736
Autor:
Corey S Frucht, Mohamed Uduman, Jamie L Duke, Steven H Kleinstein, Joseph Santos-Sacchi, Dhasakumar S Navaratnam
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11502 (2010)
Auditory hair cells spontaneously regenerate following injury in birds but not mammals. A better understanding of the molecular events underlying hair cell regeneration in birds may allow for identification and eventually manipulation of relevant pat
Externí odkaz:
https://doaj.org/article/e7fce3417f88418a8c56a0b6768e13b8
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1427
We describe a protocol to screen for protein-protein interactions using the Gal-4-based yeast two-hybrid system. In this protocol, we describe serial transformation of bait into an already constructed cDNA library in yeast AH109 cells. We find this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::64b5365e4e70d5e2749daeb4200ebad4
https://pubmed.ncbi.nlm.nih.gov/27259923
https://pubmed.ncbi.nlm.nih.gov/27259923
Publikováno v:
Methods in Molecular Biology ISBN: 9781493936137
We describe a protocol to screen for protein-protein interactions using the Gal-4 based yeast two-hybrid system. In this protocol, we describe serial transformation of bait into an already constructed cDNA library in yeast AH109 cells. We find this m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b0049c67d4c3242e5c362b058e2cb64
https://doi.org/10.1007/978-1-4939-3615-1_6
https://doi.org/10.1007/978-1-4939-3615-1_6
Publikováno v:
Journal of Biological Chemistry. 270:19238-19245
The auditory receptor epithelium is an excellent model system for studying the differential expression of ion channel genes. An inward rectifier potassium current is among those which have been measured in only subsets of chick cochlear hair cells. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363a86632310874ec98ec3c14e4bc479
https://doi.org/10.1074/jbc.270.33.19238
https://doi.org/10.1074/jbc.270.33.19238
Autor:
Dhasakumar S. Navaratnam
Publikováno v:
Methods in Molecular Biology ISBN: 9781934115626
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39cb9a2e6e9da2db19be19d2b403ef0b
https://doi.org/10.1007/978-1-59745-523-7_15
https://doi.org/10.1007/978-1-59745-523-7_15