Výsledky vyhledávání - "Dharyl C. Wilson"

A new mode of cyclobutenedione ring opening for the synthesis of 2-oxobut-3-enamides and tetrasubstituted furans

Autor: Mark E. Light, Ryan M Bennett, Wei Sun, David C. Harrowven, Dharyl C. Wilson

Publikováno v: Chemical Communications. 57:5694-5697

A dichotomy between the additions of organolithiums and lithium amides to cyclobutenediones is described wherein the former give carbonyl addition products while the latter induce ring opening by enone cleavage via O- to C-lithium transfer.This disti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a279ec584354c9656cf9778b16f6e9
https://doi.org/10.1039/d1cc02097h

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Steric Buttressing Changes Torquospecificity in Thermal Cyclobutenone Rearrangements, Providing New Opportunities for 5H-Furanone Synthesis

Autor: Dharyl C. Wilson, David C. Harrowven, Wei Sun

Publikováno v: Synthesis. 49:3091-3106

Thermally induced rearrangements of 4-hydroxycyclobutenones are known to provide clean and reliable access to an array of useful carbocyclic and fused heterocyclic ring systems. Rarely, such reactions have been diverted to an alternative pathway le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb84dbb1e872b546a0b7e6993e3e6097
https://doi.org/10.1055/s-0036-1588850

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Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS

Autor: Dharyl C. Wilson, Anqi Chen, A.S. Bienemann, Mark E. Light, F. Cuda, Daniel J. Asby, Ali Tavassoli, M. G. Radigois, Christina L. L. Chai, David C. Harrowven

Publikováno v: Asby, D J, Radigois, M G, Wilson, D C, Cuda, F, Chai, C L L, Chen, A, Bienemann, A S, Light, M E, Harrowven, D C & Tavassoli, A 2016, ' Triggering apoptosis in cancer cells with an analogue of cribrostatin 6 that elevates intracellular ROS ', Organic and Biomolecular Chemistry, vol. 14, no. 39, pp. 9322-9330 . https://doi.org/10.1039/c6ob01591c

Elevation of reactive oxygen species (ROS) is both a consequence and driver of the upregulated metabolism and proliferation of transformed cells. The resulting increase in oxidative stress is postulated to saturate the cellular antioxidant machinery,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a7929b1bbcf29f83aa92cc8e525292
https://doi.org/10.1039/c6ob01591c

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A thermally induced hydride transfer from an amine to an allene triggers an annulation reaction, giving dihydrofuropyridinones

Autor: Wei Sun, David C. Harrowven, Mark E. Light, Dharyl C. Wilson

A thermal rearrangement leading to dihydrofuropyridinones and related polycyclic ring systems from furanones and cyclobutenones is described. A key feature of the reaction is the thermally induced hydride transfer from a 3°-amine to a conjugated all

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dc83a96ed631ad34601559a68330f2
https://eprints.soton.ac.uk/422473/

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