Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Dharmpal S, Dodd"'
Autor:
Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
Publikováno v:
Journal of Medicinal Chemistry. 64:14247-14265
Inhibition of the bromodomain and extra-terminal (BET) family of adaptor proteins is an attractive strategy for targeting transcriptional regulation of key oncogenes, such as c-MYC. Starting with the screening hit 1, a combination of structure-activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6552024d7da4fe4ccaa968fbe1cf079
https://doi.org/10.1021/acs.jmedchem.1c00625
https://doi.org/10.1021/acs.jmedchem.1c00625
Autor:
Zhenqiu Hong, Brian E. Fink, Darpandeep Aulakh, Peng Li, Gregory D. Vite, Xiaoping Hou, Dawn Sun, Aaron Smith, Bei Wang, Amy A. Sarjeant, James Kempson, Arvind Mathur, Lan-Ying Qin, Martins S. Oderinde, Rulin Zhao, Peter K. Park, Lalgudi S. Harikrishnan, Dauh-Rurng Wu, Joseph Pawluczyk, Cornelius Lyndon A M, Huiping Zhang, Janet Caceres-Cortes, Shiuhang Yip, Dharmpal S. Dodd
Publikováno v:
The Journal of organic chemistry. 86(13)
We describe a stereodefined synthesis of the newly identified non-natural phosphorothioate cyclic dinucleotide (CDN) STING agonist, BMT-390025. The new route avoids the low-yielding racemic approach using P(III)-based reagents, and the stereospecific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6369d2614241414c22a55b878cc89a63
https://pubmed.ncbi.nlm.nih.gov/34126006
https://pubmed.ncbi.nlm.nih.gov/34126006
Autor:
Shana L. Posy, David A Critton, Stefan Ruepp, Ratna Kumar Sreekantha, Laxman Pasunoori, Dharmpal S. Dodd, Murali Subramanian, Andrew Watson, Percy H. Carter, Honghe Wan, Debarati Mazumder Tagore, Paul Davies, Shailesh Dudhgaonkar, Gary L. Schieven, Ratika Srivastava, Luisa Salter-Cid, Michael A. Poss, Alaric J. Dyckman, Mussari Christopher P
Publikováno v:
ACS Med Chem Lett
[Image: see text] The toll-like receptor (TLR) family is an evolutionarily conserved component of the innate immune system, responsible for the early detection of foreign or endogenous threat signals. In the context of autoimmunity, the unintended re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85418558e63333c915454e108cc2ef6
https://pubmed.ncbi.nlm.nih.gov/32944143
https://pubmed.ncbi.nlm.nih.gov/32944143
Autor:
Dauh-Rurng Wu, Zheng Yang, Steven Sheriff, Muthoni G. Kamau, Lalgudi S. Harikrishnan, Dharmpal S. Dodd, Henry Yip, Christine Huang, Yingru Zhang, Yufen Zhao, Jianqing Li, Richard A. Westhouse, Richard Rampulla, Ashvinikumar V. Gavai, Haiying Zhang, Susan Wee, Dawn Sun, Gerry Everlof, Tram N. Huynh, Ching Su, Derek J. Norris, Arvind Mathur, Wayne Vaccaro, Peng Li, Huiping Zhang, Gregory D. Vite, Mussari Christopher P, John T. Hunt, Asoka Ranasinghe, David R. Tortolani, Nirmala Raghavan, Celia D’Arienzo, Daniel O'malley, Vijay T. Ahuja, Patrice Gill, Lisa Zhang, Claude A. Quesnelle, Tokarski John S, Michael A. Poss
Publikováno v:
Cancer Research. 78:5789-5789
Background: The bromodomains and extra-terminal domain (BET) proteins are a family of 4 adapter proteins, BRD2, BRD3, BRD4, and BRDT, that bind to specific acetylated lysine residues on the histone tails of chromatin and recruit additional proteins t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad3948219544cdcb29d5e3baea4000aa
https://doi.org/10.1158/1538-7445.am2018-5789
https://doi.org/10.1158/1538-7445.am2018-5789
Autor:
Andrew J. Tebben, Wayne Vaccaro, Xiaoxia Yang, Kim W. McIntyre, Steven Sheriff, Nelly Aranibar, Dharmpal S. Dodd, Stacey Skala, Zheng Yang, Dawn K. Stetsko, Patric M Davis, Theresa Ziemba, Suzanne J. Suchard, Dominique Potin, Karishma Patel, Bang-Chi Chen, Joel C. Barrish, Zili Xiao, Albert J. DelMonte, Scott H. Watterson, Murray McKinnon, David R. Tortolani, Praveen Balimane, Pathanjali Kadiyala, Punit Marathe, Huiping Zhang, Michele Launay, Deborah Lee, ChiehYing Y. Chang, T. G. Murali Dhar
Publikováno v:
Journal of Medicinal Chemistry. 53:3814-3830
Leukocyte function-associated antigen-1 (LFA-1), also known as CD11a/CD18 or alpha(L)beta(2), belongs to the beta(2) integrin subfamily and is constitutively expressed on all leukocytes. The major ligands of LFA-1 include three intercellular adhesion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3d21c084dc54390adcd39bb85a2e9b0
https://doi.org/10.1021/jm100348u
https://doi.org/10.1021/jm100348u
Autor:
Yufen Zhao, Dharmpal S. Dodd
Publikováno v:
Tetrahedron Letters. 42:1259-1262
An efficient method for the solid-phase synthesis of N,N′-substituted acylguanidines is presented. The key-step involves the N-acylation of resin immobilized S-methylisothiourea with a variety of carboxylic acids using PyAOP as the coupling agent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac6ef1fa7ed909d580ca49e879ad7d0d
https://doi.org/10.1016/s0040-4039(00)02265-6
https://doi.org/10.1016/s0040-4039(00)02265-6
Autor:
Owen Brendan Wallace, Dharmpal S. Dodd
Publikováno v:
Tetrahedron Letters. 39:5701-5704
An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N′-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3825b2f6de2c90874d000126e30cfe62
https://doi.org/10.1016/s0040-4039(98)01197-6
https://doi.org/10.1016/s0040-4039(98)01197-6
Autor:
Miranda Fong, Norma Graber, Takao Nishi, Dawson Bealls, Dharmpal S. Dodd, Zhongqi Shen, Tracy Ebert
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2693-2698
2-Alkylsulfinyl-1,3,4-oxadiazoles have been identified as novel inhibitors of cell adhesion molecule expression on endothelial cells. These compounds have been shown to inhibit the up-regulation of ELAM-1 and VCAM-1 on activated human umbilical vein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c6992febe8cad2e6eaeeaa304b4c654
https://doi.org/10.1016/s0960-894x(96)00504-5
https://doi.org/10.1016/s0960-894x(96)00504-5
Publikováno v:
Tetrahedron. 51:5255-5276
Syntheses of all trans (6E)-5-, (10E)-9-, (14E)-16- and (18E)-20-thia-2,3-oxidosqualenes as inhibitors of 2,3-oxidosqualene-lanosterol cyclase (OSC) are reported. To mimic the natural geometry of 2,3-oxidosqualene (2,3-OS), we required E-vinyl sulfid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea4e9db704e7a6593c19b6ed6aadc92f
https://doi.org/10.1016/0040-4020(95)00213-r
https://doi.org/10.1016/0040-4020(95)00213-r
Autor:
Annapurna Pendri, Liya Kang, Kenneth E. Carlson, William R. Ewing, Jing Chen, Neil T. Burford, Chongqing Sun, Dharmpal S. Dodd, Mary Ellen Cvijic, Rose Ann F Baska, Samuel Gerritz
Publikováno v:
ACS combinatorial science. 14(3)
We have developed a solid phase synthesis route to 1,5-substituted pyrazole-4-carboxamides with three diversity points aimed at the discovery of new compounds as potential G-Protein coupled receptor (GPCR) ligands. The new chemistry involves acylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d10bab5d17877cd2b2d865fd0dd784
https://pubmed.ncbi.nlm.nih.gov/22340081
https://pubmed.ncbi.nlm.nih.gov/22340081