Zobrazeno 1 - 10
of 453
pro vyhledávání: '"Dharminder Chauhan"'
Autor:
Arghya Ray, Ting Du, Xueping Wan, Yan Song, Sindhu C. Pillai, Md. Abu Musa, Teng Fang, Jared Moore, Brian Blank, Xiaohui Du, Xi Chen, Robert Warne, Dena Sutimantanapi, Fang Lui, Tatiana Zavorotinskaya, Christophe Colas, Lori Friedman, Melissa R. Junttila, Dharminder Chauhan, Kenneth C. Anderson
Publikováno v:
Blood Cancer Journal, Vol 14, Iss 1, Pp 1-6 (2024)
Highlights CD73 is the key ectoenzyme involved in the generation of AMP-derived adenosine, which contributes to immunosuppression in the MM BM milieu. Blocking CD73 activity with a potent, selective, orally bioavailable CD73 inhibitor ORIC-533 decrea
Externí odkaz:
https://doaj.org/article/cb600363d6c64299b15c0ef4fcde06f7
Autor:
Arghya Ray, Yan Song, Ting Du, Leutz Buon, Yu-Tzu Tai, Dharminder Chauhan, Kenneth C. Anderson
Publikováno v:
Blood Cancer Journal, Vol 12, Iss 4, Pp 1-9 (2022)
Abstract Interaction of plasmacytoid dendritic cells (pDCs) with multiple myeloma (MM) cells, T- or NK-effector cells in the bone marrow (BM) microenvironment induces tumor cell growth, as well as inhibits innate and adaptive immune responses. Defini
Externí odkaz:
https://doaj.org/article/611fa179f07b433aa1412b229508b4e1
Autor:
Yan Song, Ting Du, Arghya Ray, Krishan Chauhan, Mehmet Samur, Nikhil Munshi, Dharminder Chauhan, Kenneth C. Anderson
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 1, Pp 1-5 (2021)
Externí odkaz:
https://doaj.org/article/870691a4cf854d61a2c62bf40fc63d76
Autor:
Rikio Suzuki, Shohei Kikuchi, Takeshi Harada, Naoya Mimura, Jiro Minami, Hiroto Ohguchi, Yasuhiro Yoshida, Morihiko Sagawa, Gullu Gorgun, Diana Cirstea, Francesca Cottini, Jana Jakubikova, Yu-Tzu Tai, Dharminder Chauhan, Paul G Richardson, Nikhil Munshi, Kiyoshi Ando, Teruhiro Utsugi, Teru Hideshima, Kenneth C Anderson
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0143847 (2015)
Heat shock protein (HSP)90 inhibitors have shown significant anti-tumor activities in preclinical settings in both solid and hematological tumors. We previously reported that the novel, orally available HSP90α/β inhibitor TAS-116 shows significant
Externí odkaz:
https://doaj.org/article/83ce039a22d7489a9099eed0350d4025
Autor:
Kenneth C. Anderson, Nikhil C. Munshi, Ruben D. Carrasco, Tomasz Sewastianik, Dharminder Chauhan, Paul G. Richardson, Yu-Tzu Tai, Kenneth Wen, Srikanth Talluri, Rao H. Prabhala, Stefano Malvestiti, Mariateresa Fulciniti, Giada Bianchi, Teru Hideshima, Cirino Botta, Mehmet K. Samur, Eugenio Morelli, Annamaria Gulla
The proteasome inhibitor bortezomib induces apoptosis in multiple myeloma cells and has transformed patient outcome. Using in vitro as well as in vivo immunodeficient and immunocompetent murine multiple myeloma models, we here show that bortezomib al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e138169ee058e491ce199859459794f
https://doi.org/10.1158/2643-3230.c.6550306.v1
https://doi.org/10.1158/2643-3230.c.6550306.v1
Autor:
Kenneth C. Anderson, Nikhil C. Munshi, Ruben D. Carrasco, Tomasz Sewastianik, Dharminder Chauhan, Paul G. Richardson, Yu-Tzu Tai, Kenneth Wen, Srikanth Talluri, Rao H. Prabhala, Stefano Malvestiti, Mariateresa Fulciniti, Giada Bianchi, Teru Hideshima, Cirino Botta, Mehmet K. Samur, Eugenio Morelli, Annamaria Gulla
Supp. table S1 shows immune genes regulated after treatment with bortezomib in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ff9f2514cea565acc4e55d70918a38
https://doi.org/10.1158/2643-3230.22543531
https://doi.org/10.1158/2643-3230.22543531
Autor:
Kenneth C. Anderson, Nikhil C. Munshi, Ruben D. Carrasco, Tomasz Sewastianik, Dharminder Chauhan, Paul G. Richardson, Yu-Tzu Tai, Kenneth Wen, Srikanth Talluri, Rao H. Prabhala, Stefano Malvestiti, Mariateresa Fulciniti, Giada Bianchi, Teru Hideshima, Cirino Botta, Mehmet K. Samur, Eugenio Morelli, Annamaria Gulla
Supp. Fig. 1 shows that bortezomib induces ICD in vitro. Suppl. Fig.2 shows that bortezomib treatment of co-culture of dendritic and T cells does not induce T cell maturation. Suppl. Fig. 3 shows that bortezomib-induced MM cell death promotes prolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533b49d502717094d623e99c61698ded
https://doi.org/10.1158/2643-3230.22543534.v1
https://doi.org/10.1158/2643-3230.22543534.v1
Autor:
Kenneth C. Anderson, Rolf Lewensohn, Paul Richardson, Nikhil Munshi, Claudia Paba-Prada, Jack Spira, Kristina Viktorsson, Arghya Ray, Dharminder Chauhan
PDF file - 66K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f065fa055a3e236872e0e0fbe91ecc
https://doi.org/10.1158/1078-0432.22450782.v1
https://doi.org/10.1158/1078-0432.22450782.v1
Autor:
Nicholas Mitsiades, Kenneth C. Anderson, Constantine S. Mitsiades, Paul G. Richardson, Peter O'Gorman, Martin Clynes, Leutz Buon, Teru Hideshima, Dharminder Chauhan, Nikhil C. Munshi, Noopur S. Raje, Emily Daskalaki, Elpida Charalambous, Douglas W. McMillin, Vassiliki Kotoula, Patrick J. Hayden, Melissa G. Ooi
Supplementary Data from Interactions of the Hdm2/p53 and Proteasome Pathways May Enhance the Antitumor Activity of Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a845c66dc7589f8466201841a601261
https://doi.org/10.1158/1078-0432.22439989
https://doi.org/10.1158/1078-0432.22439989
Autor:
Kenneth C. Anderson, Steven P. Treon, Nikhil Munshi, Roberto M. Lemoli, Marco Gobbi, Dharminder Chauhan, Teru Hideshima, Alberto Ballestrero, Fiammetta Monacelli, Fabrizio Montecucco, Alessio Nencioni, Luca Mastracci, Giulio Fraternali-Orcioni, Maurizio Miglino, Debora Soncini, Davide Lovera, Cao Yang, Yu-Tzu Tai, Prakrati Acharya, Chirag Acharya, Antonia Cagnetta, Michele Cea
Suppl. Fig.1. Nampt staining on normal Lymph Nodes; Suppl. Fig. 2. Nampt over-expression in BCMW.1 cells. Suppl. Fig. 3. Dose-response effect curves of FK866; Suppl. Fig. 4. Expression levels of Nampt in WM cells after BTK inhibition (GSE65816); Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4854b5d3413c40465a830b5b231a5413
https://doi.org/10.1158/1078-0432.22467756
https://doi.org/10.1158/1078-0432.22467756