CXCL10 deficiency limits macrophage infiltration, preserves lung matrix, and enables lung growth in bronchopulmonary dysplasia

Autor: Dharmesh V. Hirani, Florian Thielen, Siavash Mansouri, Soula Danopoulos, Christina Vohlen, Pinar Haznedar-Karakaya, Jasmine Mohr, Rebecca Wilke, Jaco Selle, Thomas Grosch, Ivana Mizik, Margarete Odenthal, Cristina M. Alvira, Celien Kuiper-Makris, Gloria S. Pryhuber, Christian Pallasch, S. van Koningsbruggen-Rietschel, Denise Al-Alam, Werner Seeger, Rajkumar Savai, Jörg Dötsch, Miguel A. Alejandre Alcazar

Publikováno v: Inflammation and Regeneration, Vol 43, Iss 1, Pp 1-20 (2023)

Abstract Preterm infants with oxygen supplementation are at high risk for bronchopulmonary dysplasia (BPD), a neonatal chronic lung disease. Inflammation with macrophage activation is central to the pathogenesis of BPD. CXCL10, a chemotactic and pro-

Externí odkaz: https://doaj.org/article/ee974415ba264f109c6c53e3c0e08811

Novel functional role of GH/IGF-I in neonatal lung myofibroblasts and in rat lung growth after intrauterine growth restriction.

Autor: Nawabi, Jawed, Vohlen, Christina, Dinger, Katharina, Thangaratnarajah, Chansutha, Klaudt, Christian, Garcia, Eva Lopez, Hirani, Dharmesh V., Karakaya, Pinar Haznedar, Macheleidt, Iris, Odenthal, Margarete, Nüsken, Kai D., Dötsch, Jörg, Alejandre Alcazar, Miguel A.

Publikováno v: American Journal of Physiology: Lung Cellular & Molecular Physiology; Nov2018, Vol. 315 Issue 5, pL623-L637, 15p, 2 Black and White Photographs, 2 Charts, 8 Graphs