Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Dharmesh M. Kanani"'
Autor:
Rong Fan, Davar Sansongko, Mi Jin, Fnu Namila, S. Ranil Wickramasinghe, Xianghong Qian, Dharmesh M. Kanani
Publikováno v:
Biotechnology and Bioengineering. 118:3511-3521
Constant flux virus filtration experiments were conducted to evaluate minute virus of mice retention behavior of four commercial virus filters for continuous bioprocessing applications. Fluxes chosen were guided by the Peclet number and the processin
Publikováno v:
Biotechnology Journal. 15:2000192
Expensive Protein A chromatography resins drive the need to maximize process productivity as well as resin capacity utilization. To this end, two strategies are explored. The first one is termed "super-batch," which utilizes a single short-bed-height
Autor:
David Pollard, Dharmesh M. Kanani, Renaud Jacquemart, Bradley Kachuik, Mark Brower, James G. Stout, Ying Hou
Publikováno v:
Biotechnology Progress. 31:974-982
Protein A chromatography is widely employed for the capture and purification of monoclonal antibodies (mAbs). Because of the high cost of protein A resins, there is a significant economic driving force to seek new downstream processing strategies. Me
Autor:
Andrew L. Zydney, Nigel B. Jackson, Ralf Kuriyel, Dharmesh M. Kanani, Meisam Bakhshayeshi, Robert van Reis, Amit Mehta
Publikováno v:
Journal of Membrane Science. 379:239-248
Dextran sieving (or retention) tests have become a standard method for characterizing the pore size distribution of ultrafiltration membranes. The objective of this work was to extend this methodology to the analysis of parvovirus filtration membrane
Autor:
Daniar Hussain, Matthew R. Long, Oleg Shinkazh, Andrew L. Zydney, Morgan Barth, Dharmesh M. Kanani
Publikováno v:
Biotechnology and Bioengineering. 108:582-591
Recent advances in cell culture technology have created significant pressure on the downstream purification process, leading to a “downstream bottleneck” in the production of recombinant therapeutic proteins for the treatment of cancer, genetic d
Autor:
Dharmesh M. Kanani, Shuvo Roy, William H. Fissell, Subhra Datta, Andrew L. Zydney, A. T. Conlisk
Publikováno v:
Journal of Colloid and Interface Science. 348:85-95
The inference of the surface charge of polyethylene glycol (PEG)-coated and uncoated silicon membranes with nanoscale pore sizes from streaming potential measurements in the presence of finite electric double layer (EDL) effects is studied theoretica
Publikováno v:
Journal of Membrane Science. 320:372-380
A rapid characterization method was used to study protein fouling of cellulose acetate membrane during dead-end, in-line, constant flux microfiltration. Based on pressure-permeate volume profiles, two fouling phases could be identified and compared a
Publikováno v:
Journal of Membrane Science. 315:1-10
In-line microfiltration which is widely used for sterilization of therapeutic proteins prior to formulation is frequently operated at constant flux by pumping purified protein solution through a membrane. Increase in transmembrane pressure (TMP) due
Autor:
Raja Ghosh, Tiffany Wong, Elena N. Komkova, Ronald F. Childs, Dharmesh M. Kanani, Alicja M. Mika
Publikováno v:
Biochemical Engineering Journal. 35:295-300
This paper discusses the separation of human serum albumin (HSA), the most abundant protein present in plasma from human immunoglobulin G (HIgG) by membrane chromatography using a novel macroporous gel-filled membrane (designated Q Type 2). The membr
Autor:
Raja Ghosh, Dharmesh M. Kanani
Publikováno v:
Journal of Membrane Science. 290:207-215
This paper discusses a novel approach for predicting permeate flux decline in constant pressure ultrafiltration of protein solutions. A constant pressure process is assumed to be made up of a large number of small, sequential, constant flux ultrafilt