Zobrazeno 1 - 10
of 290
pro vyhledávání: '"Dharmendra Kumar, Yadav"'
Autor:
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Developing new therapeutic strategies to target specific molecular pathways has become a primary focus in modern drug discovery science. Fibroblast growth factor receptor 2 (FGFR2) is a critical signaling protein involved in various cellular
Externí odkaz:
https://doaj.org/article/949016c0b9af465587dfc868099a92e8
Autor:
Moyad Shahwan, Pratibha Prasad, Dharmendra Kumar Yadav, Nojood Altwaijry, Mohd Shahnawaz Khan, Anas Shamsi
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Depression and Parkinson’s disease (PD) are devastating psychiatric and neurological disorders that require the development of novel therapeutic interventions. Drug repurposing targeting predefined pharmacological targets is a widely use approach i
Externí odkaz:
https://doaj.org/article/0d5ec773e5514665a777f908e912f3b6
Autor:
Amir Saeed, Nehal Batra, Raja Rezgui, Khalid Alshaghdali, Ibrahim Alkhalaf, Dharmendra Kumar Yadav, Priyankar Dey
Publikováno v:
Journal of King Saud University: Science, Vol 36, Iss 9, Pp 103374- (2024)
Aim: Clostridium difficile (C. diff.) infection (CDI) is the major contributor of nosocomial infection globally. The current review aims to provide a comprehensive understanding of the mechanisms behind the critical role of intestinal 3Ms (i.e., micr
Externí odkaz:
https://doaj.org/article/a2b2fcde6eb44cf5a127bb11013d9a6b
Autor:
Khalid Alshaghdali, Munazzah Tasleem, Raja Rezgui, Talal Alharazi, Tolgahan Acar, Raed Fahad Aljerwan, Ahmed Altayyar, Samra Siddiqui, Mohd Saeed, Dharmendra Kumar Yadav, Amir Saeed
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35255- (2024)
Diabetes mellitus (DM) is a prominent contributor to morbidity and mortality in developed nations, primarily attributable to vascular complications such as atherothrombosis occurring in the coronary arteries. Aldose reductase (ALR2), the main enzyme
Externí odkaz:
https://doaj.org/article/67dd6a63112e4097ab81b13c1f038d44
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e32755- (2024)
The involvement of neuroinflammation in the pathogenesis of neurodegenerative disorders (NDs) is very significant. Currently, only symptomatic treatments exist, and there are no drugs that modify the progression of Alzheimer's disease (AD) or other N
Externí odkaz:
https://doaj.org/article/9be71b2b924f4e30b978294359dad552
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Histone deacetylase 3 (HDAC3) is a member of the histone deacetylase family that has emerged as a crucial target in the quest for novel therapeutic interventions against various complex diseases, including cancer. The repositioning of FDA-approved dr
Externí odkaz:
https://doaj.org/article/820cf28df5b64e5da931bebef58d0fbd
Autor:
Taj Mohammad, Afzal Hussain, Mohamed F. Alajmi, Saba Hasan, Dharmendra Kumar Yadav, Md. Imtaiyaz Hassan
Publikováno v:
Chemical Physics Impact, Vol 8, Iss , Pp 100458- (2024)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) plays a crucial role in signaling pathways and has emerged as an attractive target for anticancer therapy. Developing small-molecule inhibitors targeting PIK3CA has emerg
Externí odkaz:
https://doaj.org/article/e18c49aa2fc54f2c98592dd22040debe
Autor:
Anas Shamsi, Mohd Shahnawaz Khan, Dharmendra Kumar Yadav, Moyad Shahwan, Mohammad Furkan, Rizwan Hasan Khan
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/6a53caaeafc343dea79483f93bdabad2
Autor:
Mohd Shahnawaz Khan, Hamza Ahmad Mohammad, Moyad Shahwan, Dharmendra Kumar Yadav, Saleha Anwar, Dr. Anas Shamsi
Publikováno v:
ChemistryOpen, Vol 13, Iss 5, Pp n/a-n/a (2024)
Abstract Phosphodiesterase type 5 (PDE5) is a multidomain protein that plays a crucial role in regulating cellular cyclic guanosine monophosphate (cGMP), a key signaling molecule involved in various physiological processes. Dysregulation of PDE5 and
Externí odkaz:
https://doaj.org/article/8b2a4f1f748c473c8567303bdf7ddce7
Publikováno v:
ACS Omega, Vol 8, Iss 49, Pp 46967-46976 (2023)
Externí odkaz:
https://doaj.org/article/f8c09ad46d2841f888f69d29e3e72669