Ribosomal S6 kinase 1 regulates inflammaging via the senescence secretome.

Autor: Gallage S; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK.; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany., Irvine EE; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Barragan Avila JE; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Reen V; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Pedroni SMA; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Duran I; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Ranvir V; Emmy Noether Research Group, Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Epigenetic Machineries and Cancer, Heidelberg, Germany., Khadayate S; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Pombo J; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Brookes S; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Heide D; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany., Dharmalingham G; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Choudhury AI; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Singh I; Emmy Noether Research Group, Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Epigenetic Machineries and Cancer, Heidelberg, Germany., Herranz N; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Vernia S; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK., Heikenwalder M; Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany. m.heikenwaelder@dkfz-heidelberg.de.; University of Tübingen, Faculty of Medicine, Institute for Interdisciplinary Research on Cancer Metabolism and Chronic Inflammation, M3-Research Center for Malignome, Metabolome and Microbiome, Tübingen, Germany. m.heikenwaelder@dkfz-heidelberg.de., Gil J; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK. jesus.gil@imperial.ac.uk.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK. jesus.gil@imperial.ac.uk., Withers DJ; Medical Research Council Laboratory of Medical Sciences (LMS), London, UK. d.withers@imperial.ac.uk.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK. d.withers@imperial.ac.uk.

Publikováno v: Nature aging [Nat Aging] 2024 Nov; Vol. 4 (11), pp. 1544-1561. Date of Electronic Publication: 2024 Aug 29.

High-density transposon libraries utilising outward-oriented promoters identify mechanisms of action and resistance to antimicrobials.

Autor: Coward C; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Dharmalingham G; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Abdulle O; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Avis T; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Beisken S; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Breidenstein E; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Carli N; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Figueiredo L; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Jones D; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Khan N; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Malara S; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Martins J; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Nagalingam N; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Turner K; Quadram Institute, Rosalind Franklin Road, Norwich Research Park, Norwich, NR4 7UQ, UK., Wain J; Quadram Institute, Rosalind Franklin Road, Norwich Research Park, Norwich, NR4 7UQ, UK., Williams D; Nanna Therapeutics, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Powell D; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK., Mason C; Summit Therapeutics plc, The Merrifield Centre, 12 Rosemary Lane, Cambridge, CB1 3LQ, UK.

Publikováno v: FEMS microbiology letters [FEMS Microbiol Lett] 2020 Dec 14; Vol. 367 (22).

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte.

Autor: Hill PWS; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Leitch HG; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Requena CE; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Sun Z; New England Biolabs, Inc., 240 County Road, Ipswich, Massachusetts 01938, USA., Amouroux R; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Roman-Trufero M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Borkowska M; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Terragni J; New England Biolabs, Inc., 240 County Road, Ipswich, Massachusetts 01938, USA., Vaisvila R; New England Biolabs, Inc., 240 County Road, Ipswich, Massachusetts 01938, USA., Linnett S; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Bagci H; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Dharmalingham G; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Haberle V; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Lenhard B; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK., Zheng Y; New England Biolabs, Inc., 240 County Road, Ipswich, Massachusetts 01938, USA., Pradhan S; New England Biolabs, Inc., 240 County Road, Ipswich, Massachusetts 01938, USA., Hajkova P; MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.; Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.

Publikováno v: Nature [Nature] 2018 Mar 15; Vol. 555 (7696), pp. 392-396. Date of Electronic Publication: 2018 Mar 07.

Now and then in eukaryotic DNA methylation.

Autor: Stein, Richard A., Gomaa, Faris E., Raparla, Pranaya, Riber, Leise

Publikováno v: Physiological Genomics; Nov2024, Vol. 56 Issue 11, p741-763, 23p

Genetic Inactivation of Notch1 Synergizes with Loss of Trp53 to Induce Tumor Formation in the Adult Mouse Forebrain.

Autor: Parmigiani, Elena¹ (AUTHOR), Giachino, Claudio¹ (AUTHOR) claudio.giachino@unibas.ch

Publikováno v: Cancers. Nov2022, Vol. 14 Issue 21, p5409. 13p.