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A multi-epitope/CXCL11 prime/pull coronavirus mucosal vaccine boosts the frequency and the function of lung-resident memory CD4⁺ and CD8⁺ T cells and enhanced protection against COVID-19-like symptoms and death caused by SARS-CoV-2 infection

Autor: Latifa Zayou^1,2, Prakash, Swayam¹, Dhanushkodi, Nisha Rajeswari¹, Quadiri, Afshana¹, Ibraim, Izabela Coimbra³, Singer, Mahmoud¹, Salem, Amirah¹, Shaik, Amin Mohammed¹, Suzer, Berfin¹, Chilukuri, Amruth¹, Tran, Jennifer¹, Nguyen, Pauline Chau¹, Miyo Sun¹, Hormi-Carver, Kathy K.¹, Belmouden, Ahmed², Vahed, Hawa⁴, Gil, Daniel⁴, Ulmer, Jeffrey B.⁴, BenMohamed, Lbachir^1,4,5,6 Lbenmoha@uci.edu

Publikováno v: Journal of Virology. Dec2023, Vol. 97 Issue 12, p1-17. 17p.

Therapeutic Prime/Pull Vaccination of HSV-2 Infected Guinea Pigs with the Ribonucleotide Reductase 2 (RR2) Protein and CXCL11 Chemokine Boosts Antiviral Local Tissue-Resident and Effector Memory CD4 ⁺ and CD8 ⁺ T Cells and Protects Against Recurrent Genital Herpes.

Autor: Quadiri A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Prakash S; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Dhanushkodi NR; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Singer M; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Zayou L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Shaik AM; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Sun M; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Suzer B; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Lau L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Chilukurri A; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697., Vahed H; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697.; Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, CA 92660; USA., Schaefer H; Intracellular Pathogens, Robert Koch-Institute, Berlin 13353, Germany., BenMohamed L; Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California Irvine, School of Medicine, Irvine, CA, 92697.; Institute for Immunology, University of California Irvine, School of Medicine, Irvine, CaA 92697.; Department of Vaccines and Immunotherapies, TechImmune, LLC, University Lab Partners, Irvine, CA 92660; USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 09. Date of Electronic Publication: 2023 Aug 09.