Výsledky vyhledávání - "Dhanir Tailor"

Akademický článek

Mycobacterium w - a promising immunotherapeutic intervention for diseases

Autor: Kirsten Stefan, Ryan Gordon, Annah Rolig, Alexander Honkala, Dhanir Tailor, Lara E. Davis, Rajiv I. Modi, Manjul Joshipura, Bakulesh Khamar, Sanjay V. Malhotra

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications

Externí odkaz: https://doaj.org/article/0fbec12d16034f86b9ba00e063ba8834

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Akademický článek

Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization

Autor: Sushil Kumar, Dhanir Tailor, Arpit Dheeraj, Wenqi Li, Kirsten Stefan, Jee Min Lee, Dylan Nelson, Bailey F. Keefe, Pepper Schedin, Shivaani Kummar, Lisa M. Coussens, Sanjay V. Malhotra

Publikováno v: Cell Reports Medicine, Vol 5, Iss 9, Pp 101698- (2024)

Summary: Tumor-associated macrophages (TAMs) and other myelomonocytic cells are implicated in regulating responsiveness to immunotherapies, including immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis. We have developed an ex vivo high

Externí odkaz: https://doaj.org/article/cfaf32627f2d4969978c0e42493daa35

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Akademický článek

Impact of an Immune Modulator Mycobacterium-w on Adaptive Natural Killer Cells and Protection Against COVID-19

Autor: Sarita Rani Jaiswal, Jaganath Arunachalam, Ashraf Saifullah, Rohit Lakhchaura, Dhanir Tailor, Anupama Mehta, Gitali Bhagawati, Hemamalini Aiyer, Bakulesh Khamar, Sanjay V. Malhotra, Suparno Chakrabarti

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

The kinetics of NKG2C+ adaptive natural killer (ANK) cells and NKG2A+inhibitory NK (iNK) cells with respect to the incidence of SARS-CoV-2 infection were studied for 6 months in a cohort of healthcare workers following the administration of the heat-

Externí odkaz: https://doaj.org/article/d87b5e5b06364190ae7b4af8f61af174

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Akademický článek

Augmenting Vaccine Efficacy against Delta Variant with ‘Mycobacterium-w’-Mediated Modulation of NK-ADCC and TLR-MYD88 Pathways

Autor: Sarita Rani Jaiswal, Ashraf Saifullah, Jaganath Arunachalam, Rohit Lakhchaura, Dhanir Tailor, Anupama Mehta, Gitali Bhagawati, Hemamalini Aiyer, Subhrajit Biswas, Bakulesh Khamar, Sanjay V. Malhotra, Suparno Chakrabarti

Publikováno v: Vaccines, Vol 11, Iss 2, p 328 (2023)

Mycobacterium-w (Mw) was shown to boost adaptive natural killer (ANK) cells and protect against COVID-19 during the first wave of the pandemic. As a follow-up of the trial, 50 healthcare workers (HCW) who had received Mw in September 2020 and subsequ

Externí odkaz: https://doaj.org/article/862f2163e9b04ac0acd6cdb0f2c50d4d

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Akademický článek

Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer

Autor: Alexander T. Honkala, Dhanir Tailor, Sanjay V. Malhotra

Publikováno v: Frontiers in Immunology, Vol 10 (2020)

Guanylate-binding protein 1 (GBP1) is a large GTPase of the dynamin superfamily involved in the regulation of membrane, cytoskeleton, and cell cycle progression dynamics. In many cell types, such as endothelial cells and monocytes, GBP1 expression is

Externí odkaz: https://doaj.org/article/3959f05699054e25809a2649442e08df

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