Feedforward and disinhibitory circuits differentially control activity of cortical somatostatin interneurons during behavioral state transitions

Autor: Marcel de Brito Van Velze, Dhanasak Dhanasobhon, Marie Martinez, Annunziato Morabito, Emmanuelle Berthaux, Cibele Martins Pinho, Yann Zerlaut, Nelson Rebola

Publikováno v: Cell Reports, Vol 43, Iss 5, Pp 114197- (2024)

Summary: Interneurons (INs), specifically those in disinhibitory circuits like somatostatin (SST) and vasoactive intestinal peptide (VIP)-INs, are strongly modulated by the behavioral context. Yet, the mechanisms by which these INs are recruited duri

Externí odkaz: https://doaj.org/article/a6f9936fefc4479f8dff58308c3b54f3

Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain

Autor: Dhanasak Dhanasobhon, Maria-Carmen Medrano, Léa J. Becker, Yunuen Moreno-Lopez, Sehrazat Kavraal, Charlotte Bichara, Rémy Schlichter, Perrine Inquimbert, Ipek Yalcin, Matilde Cordero-Erausquin

Publikováno v: Neurobiology of Disease, Vol 155, Iss , Pp 105363- (2021)

Endogenous acetylcholine (ACh) is an important modulator of nociceptive sensory processing in the spinal cord. An increased level of spinal ACh induces analgesia both in humans and rodents while interfering with cholinergic signaling is allodynic, de

Externí odkaz: https://doaj.org/article/a0a28af3ceee48c8ba41ff8ffd52d33b

The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo

Autor: Jaime de Juan-Sanz, Anjali Amrapali Vishwanath, Andrés de la Rocha-Muñoz, Beatriz López-Corcuera, Carmen Aragón, Dhanasak Dhanasobhon, Nelson Rebola, Enrique Núñez, Sergio Gomez-Lopez

Publikováno v: Communications Biology
Communications Biology, 2021, 4 (1), ⟨10.1038/s42003-021-02718-6⟩
Communications Biology, Nature Publishing Group, 2021, 4 (1), ⟨10.1038/s42003-021-02718-6⟩
Communications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Biblos-e Archivo. Repositorio Institucional de la UAM

The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine back to presynaptic terminals to preserve vesicular glycine content. GlyT2 loss-of-function mutation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763a8937199a6211ceda3e3e8cac50c5
https://hal.sorbonne-universite.fr/hal-03388656

Enhanced analgesic cholinergic tone after neuropathy

Autor: Matilde Cordero-Erausquin, Ipek Yalcin, Dhanasak Dhanasobhon, Yunuen Moreno-Lopez, Maria-Carmen Medrano, Rémy Schlichter, Charlotte Bichara, Perrine Inquimbert, Sehrazat Kavraal

At the spinal cord level, a tone of endogenous acetylcholine (ACh) modulates nociceptive sensory processing. Increasing the level of spinal ACh induces analgesia in naïve animals or in situation of acute pain in the clinics, but whether this is stil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::314f4a2f7f85f37681e0492716074ef4
https://doi.org/10.1101/2020.06.11.146852

To phosphorylate or not to phosphorylate: Selective alterations in tyrosine kinase-inhibited EphB mutant mice

Autor: Elise Savier, Dhanasak Dhanasobhon, Vincent Lelievre

Publikováno v: Europe PubMed Central

EphB tyrosine kinase receptors have been implicated in multiple developmental processes; however, the signaling mechanism underlying these events remains unclear. Through a triple knock-in mouse line for three neurally expressed EphBs, Sokis et al. d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c63dfef91db7092da062a966717b44
http://europepmc.org/abstract/med/24589619