Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dhanarajan Rajakumar"'
Autor:
Nicolas Wein, Tatyana A. Vetter, Adeline Vulin, Tabatha R. Simmons, Emma C. Frair, Adrienne J. Bradley, Liubov V. Gushchina, Camila F. Almeida, Nianyuan Huang, Daniel Lesman, Dhanarajan Rajakumar, Robert B. Weiss, Kevin M. Flanigan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 279-293 (2022)
Duchenne muscular dystrophy (DMD) is typically caused by mutations that disrupt the DMD reading frame, but nonsense mutations in the 5′ part of the gene induce utilization of an internal ribosomal entry site (IRES) in exon 5, driving expression of
Externí odkaz:
https://doaj.org/article/937ffb28cf15459caaa9793b8cebec7b
Autor:
Camila F. Almeida, Florence Robriquet, Tatyana A. Vetter, Nianyuan Huang, Reid Neinast, Lumariz Hernandez-Rosario, Dhanarajan Rajakumar, W. David Arnold, Kim L. McBride, Kevin M. Flanigan, Robert B. Weiss, Nicolas Wein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults and affects mainly the skeletal muscle, heart, and brain. DM1 is caused by a CTG repeat expansion in the 3′UTR region of the DMPK gene that sequesters musclebli
Externí odkaz:
https://doaj.org/article/64f77f1950614b9e88620a368751f95d
Publikováno v:
Human gene therapy. 32(21-22)
The uridine-rich 7 (U7) small nuclear RNA (snRNA) is a component of a small nuclear ribonucleoprotein (snRNP) complex. U7 snRNA naturally contains an antisense sequence that identifies histone premessenger RNAs (pre-mRNAs) and is involved in their 3'
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da9c6500947dce9c7d69ea9bdda4a0af
https://pubmed.ncbi.nlm.nih.gov/34139889
https://pubmed.ncbi.nlm.nih.gov/34139889
Publikováno v:
The Journal of Neuroscience. 35:372-385
ArcLight is a genetically encoded fluorescent voltage sensor using the voltage-sensing domain of the voltage-sensing phosphatase fromCiona intestinalisthat gives a large but slow-responding optical signal in response to changes in membrane potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02603d0155390d54b65010a2902ba9d2
https://doi.org/10.1523/jneurosci.3008-14.2015
https://doi.org/10.1523/jneurosci.3008-14.2015
Publikováno v:
Life Sciences. 108:54-61
Aims Dysferlinopathies are autosomal recessive neuromuscular disorders arising from mutations of the protein dysferlin that preferentially affect the limbs which waste and weaken. The pathomechanisms of the diseases are not known and effective treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4584d608e041cf13df18d21fbfb3b04
https://doi.org/10.1016/j.lfs.2014.05.005
https://doi.org/10.1016/j.lfs.2014.05.005
Publikováno v:
Neurochemical Research. 38:2009-2018
The neuromuscular disorder, calpainopathy (LGMD 2A), is a major muscular dystrophy classified under limb girdle muscular dystrophies. Genetic mutations of the enzyme calpain 3 cause LGMD 2A. Calpainopathy is phenotypically observed as progressive mus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a21a49af83a00d8e44139897b1b2789
https://doi.org/10.1007/s11064-013-1107-z
https://doi.org/10.1007/s11064-013-1107-z
Publikováno v:
Biophysical Journal. 108(2)
The field of optogenetics has extensively improved over the last couple years allowing optical detection of single action potentials [CITE PAPERS]. In order to improve voltage sensors, a search strategy using the highly conserved S2 trans-membrane mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf1d60ec91f80d5d2f7a796d8b4e13d
Publikováno v:
Biophysical Journal. (2):151a-152a
Genetically-encoded fluorescent voltage sensors enable the optical reporting of changes in membrane potentials. These sensors consist of a voltage-sensing domain of voltage-sensing phosphatase (usually from Ciona intestinalis Voltage-Sensing phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d20dead982ea83c29c70a3804a5104