Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Dhammika Weerakkody"'
Autor:
Donald M. Engelman, Yana K. Reshetnyak, Dhammika Weerakkody, Gregory Slaybaugh, Oleg A. Andreev
Publikováno v:
Proc Natl Acad Sci U S A
To advance mechanistic understanding of membrane-associated peptide folding and insertion, we have studied the kinetics of three single tryptophan pHLIP (pH-Low Insertion Peptide) variants, where tryptophan residues are located near the N terminus, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1674a1d8b4bc0e4aea163e86ea4256bb
https://europepmc.org/articles/PMC7275707/
https://europepmc.org/articles/PMC7275707/
Autor:
Donald M. Engelman, Oleg A. Andreev, Yana K. Reshetnyak, Alexander G. Karabadzhak, John C. Deacon, Dhammika Weerakkody
Publikováno v:
Biophysical Journal. 114:2107-2115
The physical properties of lipid bilayers, such as curvature and fluidity, can affect the interactions of polypeptides with membranes, influencing biological events. Additionally, given the growing interest in peptide-based therapeutics, understandin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d1c685cb4543718f1c77082ae2d38
https://doi.org/10.1016/j.bpj.2018.03.036
https://doi.org/10.1016/j.bpj.2018.03.036
Autor:
Troy Crawford, Yana K. Reshetnyak, John Shen, Oleg A. Andreev, Michael DuPont, Dhammika Weerakkody, Anna Moshnikova
Publikováno v:
Biophysical Journal. 120:86a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20c6974aee8eccb97bcdc8aa92cc4998
https://doi.org/10.1016/j.bpj.2020.11.729
https://doi.org/10.1016/j.bpj.2020.11.729
Publikováno v:
Biochemistry and Biophysics Reports
The investigation of pH-dependent membrane-associated folding has both fundamental interest and practical applications for targeting of acidic tumors and specific delivery of therapeutic molecules across membrane of cancer cells. We and others invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b071fa3df647488d1bd9ee9f9b1c3bd9
https://doi.org/10.1016/j.bbrep.2016.10.001
https://doi.org/10.1016/j.bbrep.2016.10.001
Autor:
Alexander G. Karabadzhak, Theyencheri Narayanan, Dhammika Weerakkody, Michael Anderson, Yana K. Reshetnyak, Oleg A. Andreev
Publikováno v:
The Journal of Physical Chemistry B. 120:11484-11491
pH (Low) Insertion Peptides (pHLIP peptides) find application in studies of membrane-associated folding because spontaneous insertion of these peptides is conveniently triggered by varying pH. Here, we employed small-angle X-ray scattering (SAXS) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dc8cef0631da9215a8d2d7933a116dd
https://doi.org/10.1021/acs.jpcb.6b06643
https://doi.org/10.1021/acs.jpcb.6b06643
Autor:
Johanna Marie Csengery, Daniel Richard Marshall, Per Hellsund, Ranjit S. Bindra, Oleg A. Andreev, Peter M. Glazer, Yana K. Reshetnyak, Laurie Tylaska, Dhammika Weerakkody, Hanna Visca, Timothy Joseph Paradis, Jane Bechtold, Robert J. Aiello, Vishwas M. Paralkar, Qing Zhang, Donald M. Engelman, Anna Moshnikova, Brett S. Robinson, Gregory Slaybaugh, Patricia Bourassa, Lori Lopresti-Morrow
Publikováno v:
Cancer Research. 79:2981-2981
Poly (ADPribose) polymerase inhibitors (PARPi) have shown great promise in the treatment of cancer, however, their current clinical use has been largely limited to homologous recombination-deficient (HRD) tumors. While these drugs are efficacious as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14574defd0d4effb1812a40ffd714e4
https://doi.org/10.1158/1538-7445.am2019-2981
https://doi.org/10.1158/1538-7445.am2019-2981
Autor:
Oleg A. Andreev, Valentina Moshnikova, Jennifer Daniels, Mak S. Thakur, Yana K. Reshetnyak, Donald M. Engelman, Anna Moshnikova, Dhammika Weerakkody
Publikováno v:
Proceedings of the National Academy of Sciences. 110:5834-5839
Cancer is a complex disease with a range of genetic and biochemical markers within and among tumors, but a general tumor characteristic is extracellular acidity, which is associated with tumor growth and development. Acidosis could be a universal mar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ece5cd6da37f6d759cdb28065b4088
https://doi.org/10.1073/pnas.1303708110
https://doi.org/10.1073/pnas.1303708110
Autor:
Dhammika Weerakkody, Jovana Golijanin, Yana K. Reshetnyak, Keykavous Parang, Naglaa Salem El-Sayed, Rakesh Tiwari, Anna Moshnikova, Ramona Adochite, Oleg A. Andreev, Gregory Slaybaugh
Publikováno v:
Scientific Reports
A series of cyclic peptides containing a number of tryptophan (W) and glutamic acid (E) residues were synthesized and evaluated as pH-sensitive agents for targeting of acidic tissue and pH-dependent cytoplasmic delivery of molecules. Biophysical stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7ea8f5fddf564d2ce41fa7faadec21
https://doi.org/10.1038/srep31322
https://doi.org/10.1038/srep31322
Autor:
Donald M. Engelman, Dhammika Weerakkody, Francisco N. Barrera, Michael Anderson, Yana K. Reshetnyak, Oleg A. Andreev
Publikováno v:
Journal of Molecular Biology. 413:359-371
We have used the pHLIP® peptide to study the roles of carboxyl groups in transmembrane peptide insertion. The pH (low) insertion peptide (pHLIP) binds to the surface of a lipid bilayer as a disordered peptide at neutral pH, and when the pH is lowere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b33340feed9bdc328f28a64c12263f
https://doi.org/10.1016/j.jmb.2011.08.010
https://doi.org/10.1016/j.jmb.2011.08.010